GB767630A - Process for the purification and separation of the vitamins of the b-group - Google Patents

Process for the purification and separation of the vitamins of the b-group

Info

Publication number
GB767630A
GB767630A GB35883/54A GB3588354A GB767630A GB 767630 A GB767630 A GB 767630A GB 35883/54 A GB35883/54 A GB 35883/54A GB 3588354 A GB3588354 A GB 3588354A GB 767630 A GB767630 A GB 767630A
Authority
GB
United Kingdom
Prior art keywords
acid
cooh
developer
salts
butanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35883/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aschaffenburger Zellstoffwerke AG
Original Assignee
Aschaffenburger Zellstoffwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aschaffenburger Zellstoffwerke AG filed Critical Aschaffenburger Zellstoffwerke AG
Publication of GB767630A publication Critical patent/GB767630A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Vitamins of the B12 group are purified by means of partition chromatography wherein the chromatographic column is filled with cellulose and the developer used comprises a single phase elution agent which consists of aqueous n-butanol containing not more than 18 per cent by volume of water or of aqueous secondary butanol containing not more than 31 per cent by volume of water. Enhanced results are obtained by effecting the development in the presence of neutral and readily dissociating salts, the anions of said salts being monobasic and consisting of at least four non-metal atoms, e.g. the sodium or potassium salts of the following acids: perchloric acid (HClO4), chloric acid (HClO3), bromic acid (HBrO3), nitric acid (HNO2), hydrogen tetraphenyl boron (H-B (C6H5)4 \sH ), monochloroacetic acid (Cl.CH2.-COOH), dichloroacetic acid (Cl2CH.COOH), trichloroacetic acid (Cl3C.COOH), monobromoacetic acid (BrCH2COOH), dibromoacetic acid (Br2CH.COOH), camphosulphonic acid, benzenesulphonic acid (C6H5SO3H), 2,4-dichlorobenzoic acid (C6H3Cl2COOH), sulphanilic acid (NH2.C6H4.SO3H) and a -naphthalene sulphonic acid. These salts may be admixed with the developer or with the chromatographic column itself and may be used in a concentration of 0.002 to 0.02 mols. per litre of developer. The cellulose column may be in powder or in flake form. The developer may contain a small quantity of hydrocyanic acid. Examples describe the separation of B12 vitamins from digested sludge water saturated n-butanol and sec.-butanol. Specification 748,043 is referred to.
GB35883/54A 1953-12-10 1954-12-10 Process for the purification and separation of the vitamins of the b-group Expired GB767630A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE767630X 1953-12-10

Publications (1)

Publication Number Publication Date
GB767630A true GB767630A (en) 1957-02-06

Family

ID=6673547

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35883/54A Expired GB767630A (en) 1953-12-10 1954-12-10 Process for the purification and separation of the vitamins of the b-group

Country Status (1)

Country Link
GB (1) GB767630A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2149407A (en) * 1983-10-04 1985-06-12 Richter Gedeon Vegyeszet Process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2149407A (en) * 1983-10-04 1985-06-12 Richter Gedeon Vegyeszet Process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids

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