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Bristol Myers Co
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Bristol Myers Co
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Publication date
Application filed by Bristol Myers CofiledCriticalBristol Myers Co
Priority to ES0334005ApriorityCriticalpatent/ES334005A1/en
Publication of ES334005A1publicationCriticalpatent/ES334005A1/en
A process for the production of penicillin amidase enzymes comprising the following steps: (1) Add to a fermentation broth containing penicillin amidase a quaternary ammonium salt and a metal compound selected from the salts and metal hydroxides with a divalent metal cation, whereby said penicillin amidase binds to the water-insoluble solids present in the aforementioned broth; (2) separating the insoluble solids in water present; (3) mixing said water-insoluble solids with water, whereby the mentioned penicillin amidase is dissolved in said water; (4) separating from the solid materials the supernatant liquid containing the penicillin amidase; (3) adding to said liquid supernatant a solid adsorbent agent incapable of adsorbing the penicillin amidase; Y (6) separating said solid adsorbent from the aqueous solution to give a purified aqueous solution of penicillin amidase. (Machine-translation by Google Translate, not legally binding)
ES0334005A1966-11-301966-11-30A procedure for the production of enzymes. (Machine-translation by Google Translate, not legally binding)
ExpiredES334005A1
(en)
A process of production of the crystalline form and relatively insoluble in cephalexin monohydrate water. (Machine-translation by Google Translate, not legally binding)
Process for the preparation of a member of the group consisting of a salt of furaltadone acid pamoate and a hydrate of the same (Machine-translation by Google Translate, not legally binding)