GB755555A - Process for the preparation of ergotamine, ergotaminine and ergometrine - Google Patents

Process for the preparation of ergotamine, ergotaminine and ergometrine

Info

Publication number
GB755555A
GB755555A GB10066/54A GB1006654A GB755555A GB 755555 A GB755555 A GB 755555A GB 10066/54 A GB10066/54 A GB 10066/54A GB 1006654 A GB1006654 A GB 1006654A GB 755555 A GB755555 A GB 755555A
Authority
GB
United Kingdom
Prior art keywords
ergometrine
alkaloids
ergotamine
culture
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10066/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB755555A publication Critical patent/GB755555A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Ergotamine, ergotaminine and ergometrine are prepared by saprophytic culture of ergot fungus in vitro in a medium containing zinc and iron ions; the mycelium and solution are then separated and worked up independently by defatting with an organic solvent (e.g. petroleum ether), making alkaline, extracting with a water-immiscible organic solvent (e.g. ether), treating the latter with an acid such as tartaric and obtaining the alkaloids from the acid extract by standard methods. The preferred concentration of iron in the culture medium is 0.75-12 X 10-5 mol. per litre and of zinc is 1.2-19.2 X 10-5 mol. per litre. Examples are given of suitable culture media containing various inorganic salts and organic nutrients. Details of the isolation are also given, the tartaric acid extract being treated with alkali and again extracted with ether, ergometrine remaining in the aqueous phase. The other two alkaloids are separated from one another by percolating a chloroform solution thereof through an alumina column. The Specification refers to earlier processes for the saprophytic culture of the ergot fungus which yielded crude mixtures or individual alkaloids different from the three of the present invention. The race of ergot effective in the present invention is that which when growing on rye produces ergotamine, ergometrine and ergosine.
GB10066/54A 1953-04-10 1954-04-06 Process for the preparation of ergotamine, ergotaminine and ergometrine Expired GB755555A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH755555X 1953-04-10

Publications (1)

Publication Number Publication Date
GB755555A true GB755555A (en) 1956-08-22

Family

ID=4534240

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10066/54A Expired GB755555A (en) 1953-04-10 1954-04-06 Process for the preparation of ergotamine, ergotaminine and ergometrine

Country Status (1)

Country Link
GB (1) GB755555A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1201949B (en) * 1960-11-11 1965-09-30 Spofa Sdruzeni Podnikuu Pro Zd Process for the biosynthetic production of ergot alkaloids by breeding ergot fungi of the genus Claviceps purpurea Tul.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1201949B (en) * 1960-11-11 1965-09-30 Spofa Sdruzeni Podnikuu Pro Zd Process for the biosynthetic production of ergot alkaloids by breeding ergot fungi of the genus Claviceps purpurea Tul.

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