GB750194A - Isonicotinamides - Google Patents

Isonicotinamides

Info

Publication number
GB750194A
GB750194A GB33516/53A GB3351653A GB750194A GB 750194 A GB750194 A GB 750194A GB 33516/53 A GB33516/53 A GB 33516/53A GB 3351653 A GB3351653 A GB 3351653A GB 750194 A GB750194 A GB 750194A
Authority
GB
United Kingdom
Prior art keywords
amino
carbon atoms
formula
lower aliphatic
isonicotinamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33516/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Publication of GB750194A publication Critical patent/GB750194A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0750194/IV(a)/1> wherein X is oxygen or sulphur and R2 and R3 are alike or different and are hydrogen or lower aliphatic alkyl radicals (containing one to eight carbon atoms). Such compounds are obtained by reacting a compound of the formula <FORM:0750194/IV(a)/2> wherein R is halogen or an aliphatic alkoxy radical of one to eight carbon atoms inclusive with an N-amino-heterocyclic compound of the formula <FORM:0750194/IV(a)/3> or a salt thereof with hydrochloric acid in benzene, a lower aliphatic alcohol or a diluted lower aliphatic alcohol containing one to eight carbon atoms, at a temperature between 15 DEG C. and the boiling temperature of the selected solvent, if desired in the presence of a sodium acetate buffer solution. A slight excess, e.g. 1.05 to 1.5 mols., of the N-aminoheterocyclic compound per mol. of the isonicotinic acid ester or halide is employed. In examples (1) 1-isonicotinamidohydantoin is prepared by reacting N-amino-hydantoin with isonicotinyl chloride; (2) ethyl isonicotinate and 1-amino-3,5-dimethyl hydantoin are reacted in an aqueous alcohol solution of sodium acetate to form 1-isonicotinamido - 3,5 - dimethylhydantoin; (3) isonicotinyl chloride and 1-amino-2-thiohydantoin are reacted together in benzene to form 1-isonicotinamido - 2 - thiohydantoin. Specification 711,756 is referred to.
GB33516/53A 1952-12-05 1953-12-02 Isonicotinamides Expired GB750194A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT750194X 1952-12-05

Publications (1)

Publication Number Publication Date
GB750194A true GB750194A (en) 1956-06-13

Family

ID=11315635

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33516/53A Expired GB750194A (en) 1952-12-05 1953-12-02 Isonicotinamides

Country Status (1)

Country Link
GB (1) GB750194A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007699A1 (en) * 1997-08-12 1999-02-18 Reshetov, Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465476B1 (en) 1997-08-11 2002-10-15 Alexandr Leonidovich Reshetov Immuno-modulator exhibiting antimicrobial and anti-mycrobacterial activities, method for producing the same and pharmaceutical preparation
WO1999007699A1 (en) * 1997-08-12 1999-02-18 Reshetov, Alexandr Leonidovich Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting immuno-deficiency

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