GB737242A - Process of increasing the physical stability of aqueous suspensions of penicillin compounds - Google Patents

Process of increasing the physical stability of aqueous suspensions of penicillin compounds

Info

Publication number
GB737242A
GB737242A GB25652/53A GB2565253A GB737242A GB 737242 A GB737242 A GB 737242A GB 25652/53 A GB25652/53 A GB 25652/53A GB 2565253 A GB2565253 A GB 2565253A GB 737242 A GB737242 A GB 737242A
Authority
GB
United Kingdom
Prior art keywords
penicillin
physical stability
aqueous suspensions
suspensions
increasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25652/53A
Inventor
Karl Petersen
Hans Jacobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of GB737242A publication Critical patent/GB737242A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

The physical stability of aqueous suspensions of penicillin compounds is improved by removing the atmospheric oxygen from the unfilled space in the containers in which the suspensions are stored, before, during or after the suspensions are filled into these containers. The air may be replaced by an inert gas such as nitrogen, hydrogen, carbon dioxide or the rare gases such as helium and argon, or mixtures thereof especially mixtures of hydrogen and nitrogen. Penicillin compounds specified are procaine penicillin; N : N-dibenzyl-ethylene diamine penicillin; oxyprocaine penicillin; 2 - chloro - procaine penicillin and hydroiodide of diethylamino ethyl ester.
GB25652/53A 1952-10-16 1953-09-16 Process of increasing the physical stability of aqueous suspensions of penicillin compounds Expired GB737242A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK737242X 1952-10-16

Publications (1)

Publication Number Publication Date
GB737242A true GB737242A (en) 1955-09-21

Family

ID=8152566

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25652/53A Expired GB737242A (en) 1952-10-16 1953-09-16 Process of increasing the physical stability of aqueous suspensions of penicillin compounds

Country Status (3)

Country Link
CY (1) CY167A (en)
GB (1) GB737242A (en)
MY (1) MY5800002A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT388671B (en) * 1982-09-10 1989-08-10 Glaxo Group Ltd METHOD FOR STABILIZING A SOLID PHARMACEUTICAL COMPOSITION
EP1625859A1 (en) * 2004-08-13 2006-02-15 Access Group ApS A process for the preparation of a package comprising a sterilised bulk of a substance, and a package comprising a sterilised bulk of a penicilin
ES2302590A1 (en) * 2005-12-14 2008-07-16 Jose Martinez Nieto Method for filling blisters, involves sterilizing product before entering to blisters, where sterilizing condition are maintained and product are entered in blisters through nozzles, where waste air is eliminated

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT388671B (en) * 1982-09-10 1989-08-10 Glaxo Group Ltd METHOD FOR STABILIZING A SOLID PHARMACEUTICAL COMPOSITION
EP1625859A1 (en) * 2004-08-13 2006-02-15 Access Group ApS A process for the preparation of a package comprising a sterilised bulk of a substance, and a package comprising a sterilised bulk of a penicilin
WO2006015603A1 (en) * 2004-08-13 2006-02-16 Access Group Aps A process for the preparation of a package comprising a sterilised bulk of a drug substance, and a package comprising a sterilised bulk ofa penicillin
ES2302590A1 (en) * 2005-12-14 2008-07-16 Jose Martinez Nieto Method for filling blisters, involves sterilizing product before entering to blisters, where sterilizing condition are maintained and product are entered in blisters through nozzles, where waste air is eliminated

Also Published As

Publication number Publication date
MY5800002A (en) 1958-12-31
CY167A (en) 1958-01-02

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