GB736433A - Nutrient fat emulsions and their preparation - Google Patents

Nutrient fat emulsions and their preparation

Info

Publication number
GB736433A
GB736433A GB2372/53A GB237253A GB736433A GB 736433 A GB736433 A GB 736433A GB 2372/53 A GB2372/53 A GB 2372/53A GB 237253 A GB237253 A GB 237253A GB 736433 A GB736433 A GB 736433A
Authority
GB
United Kingdom
Prior art keywords
pyrogen
sugar
per cent
fat
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2372/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB736433A publication Critical patent/GB736433A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/14Derivatives of phosphoric acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Stable dispersions for intravenous feeding comprise fat and lecitin dispersed as 0.5-1 micron particles in an aqueous solution of a sugar. The fat is preferably a vegetable oil which remains clear and fluid at temperatures in the range 0-15 DEG C., e.g. is sesame or olive oil. The sugar may be dextrose or levulose. The dispersion may contain 20-30 per cent of fat, 0.5-2 per cent of lecithin and 5 per cent of sugar. According to an example, pyrogen-free sesame oil in isopropanol, pyrogen-free soya bean lecithin in chloroform, and dextrose in pyrogen-free water are mixed, and heated to 45 DEG C., in a high-speed stirrer, more water is stirred in, the resulting dispersion is concentrated, and the organic solvents are removed, by treatment in a long tube evaporator at 20 DEG C. under reduced pressure, and finally the product is sterilized by autoclaving at 120 DEG C. for 30 minutes.
GB2372/53A 1952-02-06 1953-01-27 Nutrient fat emulsions and their preparation Expired GB736433A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US736433XA 1952-02-06 1952-02-06

Publications (1)

Publication Number Publication Date
GB736433A true GB736433A (en) 1955-09-07

Family

ID=22114926

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2372/53A Expired GB736433A (en) 1952-02-06 1953-01-27 Nutrient fat emulsions and their preparation

Country Status (1)

Country Link
GB (1) GB736433A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1249454B (en) * 1960-08-26 1967-09-07 Vitrum Apoteksvar Process for the preparation of intravenously administrable fat emulsions
WO2006079410A1 (en) * 2005-01-28 2006-08-03 Unilever Plc Method of preparing carrier liquids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1249454B (en) * 1960-08-26 1967-09-07 Vitrum Apoteksvar Process for the preparation of intravenously administrable fat emulsions
WO2006079410A1 (en) * 2005-01-28 2006-08-03 Unilever Plc Method of preparing carrier liquids

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