GB736433A - Nutrient fat emulsions and their preparation - Google Patents
Nutrient fat emulsions and their preparationInfo
- Publication number
- GB736433A GB736433A GB2372/53A GB237253A GB736433A GB 736433 A GB736433 A GB 736433A GB 2372/53 A GB2372/53 A GB 2372/53A GB 237253 A GB237253 A GB 237253A GB 736433 A GB736433 A GB 736433A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrogen
- sugar
- per cent
- fat
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000839 emulsion Substances 0.000 title 1
- 235000015097 nutrients Nutrition 0.000 title 1
- 239000006185 dispersion Substances 0.000 abstract 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 2
- 239000008121 dextrose Substances 0.000 abstract 2
- 229940067606 lecithin Drugs 0.000 abstract 2
- 235000010445 lecithin Nutrition 0.000 abstract 2
- 239000000787 lecithin Substances 0.000 abstract 2
- 239000008159 sesame oil Substances 0.000 abstract 2
- 235000011803 sesame oil Nutrition 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000000231 Sesamum indicum Species 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 229960002737 fructose Drugs 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000004006 olive oil Substances 0.000 abstract 1
- 235000008390 olive oil Nutrition 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/14—Derivatives of phosphoric acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Stable dispersions for intravenous feeding comprise fat and lecitin dispersed as 0.5-1 micron particles in an aqueous solution of a sugar. The fat is preferably a vegetable oil which remains clear and fluid at temperatures in the range 0-15 DEG C., e.g. is sesame or olive oil. The sugar may be dextrose or levulose. The dispersion may contain 20-30 per cent of fat, 0.5-2 per cent of lecithin and 5 per cent of sugar. According to an example, pyrogen-free sesame oil in isopropanol, pyrogen-free soya bean lecithin in chloroform, and dextrose in pyrogen-free water are mixed, and heated to 45 DEG C., in a high-speed stirrer, more water is stirred in, the resulting dispersion is concentrated, and the organic solvents are removed, by treatment in a long tube evaporator at 20 DEG C. under reduced pressure, and finally the product is sterilized by autoclaving at 120 DEG C. for 30 minutes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US736433XA | 1952-02-06 | 1952-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB736433A true GB736433A (en) | 1955-09-07 |
Family
ID=22114926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2372/53A Expired GB736433A (en) | 1952-02-06 | 1953-01-27 | Nutrient fat emulsions and their preparation |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB736433A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1249454B (en) * | 1960-08-26 | 1967-09-07 | Vitrum Apoteksvar | Process for the preparation of intravenously administrable fat emulsions |
WO2006079410A1 (en) * | 2005-01-28 | 2006-08-03 | Unilever Plc | Method of preparing carrier liquids |
-
1953
- 1953-01-27 GB GB2372/53A patent/GB736433A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1249454B (en) * | 1960-08-26 | 1967-09-07 | Vitrum Apoteksvar | Process for the preparation of intravenously administrable fat emulsions |
WO2006079410A1 (en) * | 2005-01-28 | 2006-08-03 | Unilever Plc | Method of preparing carrier liquids |
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