GB730553A - Improvements in or relating to organo-mercury compounds - Google Patents
Improvements in or relating to organo-mercury compoundsInfo
- Publication number
- GB730553A GB730553A GB20738/50A GB2073850A GB730553A GB 730553 A GB730553 A GB 730553A GB 20738/50 A GB20738/50 A GB 20738/50A GB 2073850 A GB2073850 A GB 2073850A GB 730553 A GB730553 A GB 730553A
- Authority
- GB
- United Kingdom
- Prior art keywords
- propylurea
- chloromercuri
- methoxy
- hydroxy
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229940100892 mercury compound Drugs 0.000 abstract 2
- JDVPQXZIJDEHAN-UHFFFAOYSA-N succinamic acid Chemical compound NC(=O)CCC(O)=O JDVPQXZIJDEHAN-UHFFFAOYSA-N 0.000 abstract 2
- IWJFGRNIFIABLP-UHFFFAOYSA-N 2,3-dihydroxypropylurea Chemical compound NC(=O)NCC(O)CO IWJFGRNIFIABLP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- BJFGVYCULWBXKF-UHFFFAOYSA-M chlormerodrin Chemical compound Cl[Hg]CC(OC)CNC(N)=O BJFGVYCULWBXKF-UHFFFAOYSA-M 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 229910001507 metal halide Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- VPJDULFXCAQHRC-UHFFFAOYSA-N prop-2-enylurea Chemical compound NC(=O)NCC=C VPJDULFXCAQHRC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention comprises organo-mercury compounds of the general formula <FORM:0730553/IV (b)/1> where R represents hydrogen or an alkyl group and Y represents a halogen atom, a hydroxyl group or an acyloxy group, and the preparation thereof by treating a solution of an allyl urea in water or an alcohol of the general formula ROH, where R represents an alkyl group, with the required mercuric salt of a carboxylic acid, and Y represents a halogen atom or a hydroxyl group, the reaction product is treated with an aqueous solution of an alkali metal hydroxide or halide. The alcohol may contain from 1 to 5 carbon atoms. 3-Chloromercuri - 2 - methoxy - propylurea is prepared also by hydrolysing N-(3-chloromercuri - 2 - methoxy - propylcarbamyl) succinamic acid or N-(3-chloromercuri-2-methoxy - propyl) - N1 - acetylurea with aqueous alkali metal hydroxide, and 3-bromomercuri-2-methoxy-propylurea is prepared also by hydrolysing N - (3 - bromomercuri - 2 - methoxypropylcarbamyl) succinamic acid with aqueous alkali metal hydroxide. In the examples 3-chloro-, 3-bromo-, 3-hydroxy- and 3-acetoxymercuri - 2 - methoxy - propylurea, 3 - acetoxy- and 3 - hydroxy - 2 - hydroxy - propylurea, 3-chloromercuri - 2 - ethoxy - propylurea, 3-chloromercuri - 2 - n - butoxy - propylurea and 3 - chloro - mercuri - 2 - isopropoxy - propylurea are prepared.ALSO:A therapeutic composition having diuretic properties comprises an injectable carrier e.g., an aqueous solution of an alkali metal salt, and an organo-mercury compound of the formula: <FORM:0730553/VI/1> wherein R represents hydrogen or an alkyl group, Y represents a halogen atom or a hydroxy or acyloxy group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US730553XA | 1949-08-31 | 1949-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB730553A true GB730553A (en) | 1955-05-25 |
Family
ID=22111434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20738/50A Expired GB730553A (en) | 1949-08-31 | 1950-08-22 | Improvements in or relating to organo-mercury compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB730553A (en) |
-
1950
- 1950-08-22 GB GB20738/50A patent/GB730553A/en not_active Expired
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