GB729976A - New pyrimidine derivatives and a process for their production - Google Patents
New pyrimidine derivatives and a process for their productionInfo
- Publication number
- GB729976A GB729976A GB14324/53A GB1432453A GB729976A GB 729976 A GB729976 A GB 729976A GB 14324/53 A GB14324/53 A GB 14324/53A GB 1432453 A GB1432453 A GB 1432453A GB 729976 A GB729976 A GB 729976A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- pyrimidine
- aminomethyl
- hydrogen
- benzylmercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0729976/IV (b)/1> wherein Z is oxygen or sulphur, R6 is hydrogen or alkyl and R2 is hydrogen, acyl, aroyl, alkyl or aralkyl, and their salts. They are prepared by reducing a compound of the formula <FORM:0729976/IV (b)/2> to convert the cyano group into the aminomethyl group, and if desired, forming a salt with an inorganic or organic acid. When R2 in the starting material is hydrogen, the reduction product may be treated with an acyl or aroyl halide or anhydride or with a hydrohalide ester of an alkanol or aralkanol to replace the hydrogen by an acyl, aroyl, alkyl or aralkyl radical. Conversely these radicals may be replaced by hydrogen by hydrolysis. The examples describe the preparation of (1) the dihydrochloride of 2-hydroxy-4-amino-5-aminomethyl pyrimidine; (2) 4-amino-5-aminomethyl - 2 - benzylmercapto - pyrimidine; (3) 2 - (naphthyl - (11) - methyl) - mercapto - 4-amino - 5 - amino - methyl - pyrimidine; (4) 4 - amino - 5 - aminomethyl - 6 - methyl - 2-benzylmercapto - pyrimidine; (5) 4 - amino - 2-methoxy - 5 - aminomethyl - pyrimidine; (6) 2 - benzylmercapto - 4 - amino - 5 - aminomethyl-pyrimidine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH729976X | 1952-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB729976A true GB729976A (en) | 1955-05-11 |
Family
ID=4532275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14324/53A Expired GB729976A (en) | 1952-06-27 | 1953-05-21 | New pyrimidine derivatives and a process for their production |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB729976A (en) |
-
1953
- 1953-05-21 GB GB14324/53A patent/GB729976A/en not_active Expired
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