GB720298A - Preparation of ª‰-indolyl-ª‡-oximinopropionic acid - Google Patents

Preparation of ª‰-indolyl-ª‡-oximinopropionic acid

Info

Publication number
GB720298A
GB720298A GB3001451A GB3001451A GB720298A GB 720298 A GB720298 A GB 720298A GB 3001451 A GB3001451 A GB 3001451A GB 3001451 A GB3001451 A GB 3001451A GB 720298 A GB720298 A GB 720298A
Authority
GB
United Kingdom
Prior art keywords
indolyl
acid
methyl
give
nitrite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3001451A
Inventor
David Oliver Holland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Priority to GB3001451A priority Critical patent/GB720298A/en
Publication of GB720298A publication Critical patent/GB720298A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Abstract

An ester of a -acyl-b -(3-indolyl)-propionic acid is converted into the a -oxime by treatment with an alkyl nitrite and an alkali alkoxide. The product may be hydrogenated with catalyst to give tryptophan, especially in presence of ammonia. In examples, the ethyl and methyl esters of a -aceto-b -(3-indolyl)-propionic acid are treated with butyl nitrite or amyl nitrite and sodium in alcohol, at -5 DEG to 0 DEG C. to give the a -oxime product, isolated by means of acid; the partly purified oximino acid is hydrogenated in presence of ammonia to give tryptophane. Methyl a -aceto - b - (3 - indolyl) - propionate is obtained by the action of sodium in alcohol and methyl acetoacetate on gramine, followed by methyl sulphate.
GB3001451A 1951-12-21 1951-12-21 Preparation of ª‰-indolyl-ª‡-oximinopropionic acid Expired GB720298A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3001451A GB720298A (en) 1951-12-21 1951-12-21 Preparation of ª‰-indolyl-ª‡-oximinopropionic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3001451A GB720298A (en) 1951-12-21 1951-12-21 Preparation of ª‰-indolyl-ª‡-oximinopropionic acid

Publications (1)

Publication Number Publication Date
GB720298A true GB720298A (en) 1954-12-15

Family

ID=10300875

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3001451A Expired GB720298A (en) 1951-12-21 1951-12-21 Preparation of ª‰-indolyl-ª‡-oximinopropionic acid

Country Status (1)

Country Link
GB (1) GB720298A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930798A (en) * 1956-08-03 1960-03-29 Clin Byla Ets 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930798A (en) * 1956-08-03 1960-03-29 Clin Byla Ets 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof

Similar Documents

Publication Publication Date Title
GB720298A (en) Preparation of ª‰-indolyl-ª‡-oximinopropionic acid
GB822834A (en) A method of processing waste of polyethylene terephthalate by hydrolysis
GB733650A (en) Isophorone and its homologues
GB646962A (en) Improvements in or relating to processes for the preparation of farnesylacetone
GB1009473A (en) Modified polyvinyl acetoacetic esters and process for preparing them
GB620733A (en) Improvements in and relating to carbazole derivatives
SU105998A1 (en) Method for producing pregnadienol-3B-it-20 acetate D5.16
GB1118942A (en) A process for obtaining purified glutamic acid
GB675683A (en) Process of manufacture of esters of the bis-(4-hydroxycoumarinyl-3) acetic acid
CA528234A (en) Process for treating aqueous mixture of methyl acetate, methyl alcohol and acetic acid
GB976834A (en) A novel unsaturated aldehyde and the preparation thereof
AU154243B2 (en) Improvements in process for recovering acetic acid and methanol from mixture of methyl acetate, acetic acid, methanol and water
GB937598A (en) Process for the production of reserpic acid diesters
GB876902A (en) New cyclopentanophenanthrene derivatives and process for the production thereof
GB566653A (en) Processes for the synthesis of pyrazine-monocarboxylamide
GB748470A (en) A process for the manufacture of iso-ergosterone
GB723986A (en) Preparation of n-acyltryptophan esters
GB633681A (en) Process for synthesising vinyl esters of carboxylic acids
GB848410A (en) Improvements in or relating to dipeptide derivatives
GB928128A (en) Process for the production of the methyl ethers of compounds of the yohimbane series
ES261066A1 (en) Procedure for preparation of hydroxymethyl-2-chlorine-4 phenoxyacethic acid (Machine-translation by Google Translate, not legally binding)
GB811531A (en) Process for the preparation of enol esters from ketosteroid compounds
GB591435A (en) Manufacture of n-acetyl-penicillamine and 2:5:5-trimethyl-thiazoline-4-carboxylic acid
GB661805A (en) Improvements in cyclopentanophenathrene derivatives and processes
GB734494A (en) Process for the preparation of 4-amino-5-keto-1.3.4.5-tetrahydro-benz(cd)indole