GB710773A - Process for the manufacture in one stage of benzene-sulphonacylamides - Google Patents
Process for the manufacture in one stage of benzene-sulphonacylamidesInfo
- Publication number
- GB710773A GB710773A GB23866/51A GB2386651A GB710773A GB 710773 A GB710773 A GB 710773A GB 23866/51 A GB23866/51 A GB 23866/51A GB 2386651 A GB2386651 A GB 2386651A GB 710773 A GB710773 A GB 710773A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphanilamide
- sodium
- mols
- methanol
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Benzenesulphonacylamides are made in a single-stage reaction by treating a benzenesulphonamide with esters formed from p alkylcarboxylic and aralkylcarboxylic acids and alkanols or phenols, or from arylcarboxylic acids and phenols in the presence of alkali, the amount of which is one equivalent, calculated on the benzenesulphonamide, in the case of the phenyl esters and two to three equivalents in the case of the alkyl esters. When 4-aminobenzenesulphonamide is acylated in this manner, no acylation of the 4-amino group takes place. In examples: (1) N-acetyl-p-toluenesulphonamide is made by heating together a mixture comprising p-toluenesulphonamide, ethyl acetate, sodium (2 mols.) and methanol in a closed tube; (2) N1-aceturylsulphanilamide is prepared from sulphanilamide, ethyl aceturate, sodium (2 mols.) and methanol; (3) N1-acetylsulphanilamide is obtained similarly from sulphanilamide, methyl acetate, sodium (2 mols.) and methanol; (4) N1-phenylacetylsulphanilamide is obtained from sulphanilamide, ethyl phenylacetate, methanol and sodium (2 mols.); (5) N1-acetylsulphanilamide is made by heating together sodium sulphanilamide and phenyl acetate; (6) N1-benzoylsulphanilamide is made by heating sulphanilamide with phenyl benzoate; and (7) N1 - 3,4 - dimethylbenzoylsulphanilamide is made by heating sodium sulphanilamide with phenyl 3,4-dimethylbenzoate. Specification 642,013 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT710773X | 1950-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB710773A true GB710773A (en) | 1954-06-16 |
Family
ID=3679659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23866/51A Expired GB710773A (en) | 1950-10-13 | 1951-10-12 | Process for the manufacture in one stage of benzene-sulphonacylamides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB710773A (en) |
-
1951
- 1951-10-12 GB GB23866/51A patent/GB710773A/en not_active Expired
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