GB699382A - Preparation of bisnorchola-4,6-dien-3-one-22-al - Google Patents

Preparation of bisnorchola-4,6-dien-3-one-22-al

Info

Publication number
GB699382A
GB699382A GB19918/51A GB1991851A GB699382A GB 699382 A GB699382 A GB 699382A GB 19918/51 A GB19918/51 A GB 19918/51A GB 1991851 A GB1991851 A GB 1991851A GB 699382 A GB699382 A GB 699382A
Authority
GB
United Kingdom
Prior art keywords
isoergosterone
bisnorchola
dien
mols
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19918/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB699382A publication Critical patent/GB699382A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises bisnorchola-4,6-dien-3-one-22-al having the formula <FORM:0699382/IV (b)/1> and the process for its production which comprises selectively ozonizing the 22-23 double bond of isoergosterone by reacting isoergosterone, in an organic solvent, with from about 1.0 to 1.25 mols. of ozone per mol. of isoergosterone at a temperature between about minus eighty and plus thirty degrees centigrade and decomposing the thus-produced ozonide under reductive conditions. As organic solvent there may be used methylene chloride and the ozonide is decomposed with zinc in glacial acetic acid. The reaction is preferably effected using 1.0 to 1.1 mols. of ozone per mol. of isoergosterone.
GB19918/51A 1950-09-09 1951-08-23 Preparation of bisnorchola-4,6-dien-3-one-22-al Expired GB699382A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US699382XA 1950-09-09 1950-09-09

Publications (1)

Publication Number Publication Date
GB699382A true GB699382A (en) 1953-11-04

Family

ID=22092131

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19918/51A Expired GB699382A (en) 1950-09-09 1951-08-23 Preparation of bisnorchola-4,6-dien-3-one-22-al

Country Status (1)

Country Link
GB (1) GB699382A (en)

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