GB699140A - Improvements in or relating to arylmethylamine derivatives - Google Patents

Improvements in or relating to arylmethylamine derivatives

Info

Publication number
GB699140A
GB699140A GB29814/52A GB2981452A GB699140A GB 699140 A GB699140 A GB 699140A GB 29814/52 A GB29814/52 A GB 29814/52A GB 2981452 A GB2981452 A GB 2981452A GB 699140 A GB699140 A GB 699140A
Authority
GB
United Kingdom
Prior art keywords
hydrochloride
acetylfluorene
ethylfluorene
morpholinyl
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29814/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB699140A publication Critical patent/GB699140A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention comprises fluorene compounds of the general formula <FORM:0699140/IV (b)/1> wherein R is an alkyl radical, and either R1 is hydrogen and R11 is a hydroxyalkyl radical, or <FORM:0699140/IV (b)/2> is a heterocyclic ring; and also the hydrohalide salts of such compounds. In examples: (1) 2-acetylfluorene and ethanolamine in isopropanol are heated with hydrogen in the presence of Raney nickel to yield 2-(11-b -hydroxyethylamino) - ethylfluorene hydrochloride; (2) 2-acetylfluorene, N-formylpiperidine and magnesium chloride hexahydrate are heated together to yield 2-(11-piperidinyl)-ethylfluorene hydrochloride; (3) and (4) 2-(11-morpholinyl)-propylfluorene hydrochloride and 2-(11 - morpholinyl) - butylfluorene hydrochloride are similarly prepared by the method of (2) from N-formylmorpholine and 2-propionylfluorene or 2-butyrylfluorene, respectively.
GB29814/52A 1950-01-24 1950-12-21 Improvements in or relating to arylmethylamine derivatives Expired GB699140A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US699140XA 1950-01-24 1950-01-24

Publications (1)

Publication Number Publication Date
GB699140A true GB699140A (en) 1953-10-28

Family

ID=22091984

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29814/52A Expired GB699140A (en) 1950-01-24 1950-12-21 Improvements in or relating to arylmethylamine derivatives

Country Status (1)

Country Link
GB (1) GB699140A (en)

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