GB675025A - Process for producing dextran products for pharmaceutical and therapeutical preparations - Google Patents

Process for producing dextran products for pharmaceutical and therapeutical preparations

Info

Publication number
GB675025A
GB675025A GB22629/49A GB2262949A GB675025A GB 675025 A GB675025 A GB 675025A GB 22629/49 A GB22629/49 A GB 22629/49A GB 2262949 A GB2262949 A GB 2262949A GB 675025 A GB675025 A GB 675025A
Authority
GB
United Kingdom
Prior art keywords
dextran
micro
organisms
enzyme
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22629/49A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of GB675025A publication Critical patent/GB675025A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2451—Glucanases acting on alpha-1,6-glucosidic bonds
    • C12N9/2454—Dextranase (3.2.1.11)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C12P19/08—Dextran

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

675,025. Micro-biological degradation of dextran. AKTIEBOLAGET PHARMACIA. Aug. 31, 1949 [Oct. 14, 1948], No. 22629/49. Class 81 (i). [Also in Group V] Dextran products suitable for therapeutic preparations are made by subjecting dextran to a degradation by the action of micro-organisms cultivated on a dextran-containing substrate, or enzymes of such micro-organisms, and interrupting the treatment at a point where a 4 per cent aqueous solution of the products shows a viscosity between 1.2 and 15 relative to water. Cellivibro fulva or an enzyme thereof may be used. The substrate in addition to dextran may contain sodium nitrate, dipotassium hydrogen phosphate and magnesium sulphate and may have a pH of 5.2. The process may be interrupted by grinding the bacteria in the culture medium or by heating to destroy the enzyme. The product may be purified by dialysis or by precipitation with alcohol. The Specification as open to inspection under Sect. 91, refers to the use of moulds, yeasts and other kinds of fungi as the micro-organisms. This subject-matter does not appear in the Specification as accepted.
GB22629/49A 1948-10-14 1949-08-31 Process for producing dextran products for pharmaceutical and therapeutical preparations Expired GB675025A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE675025X 1948-10-14

Publications (1)

Publication Number Publication Date
GB675025A true GB675025A (en) 1952-07-02

Family

ID=20314735

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22629/49A Expired GB675025A (en) 1948-10-14 1949-08-31 Process for producing dextran products for pharmaceutical and therapeutical preparations

Country Status (1)

Country Link
GB (1) GB675025A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2742365A (en) * 1954-08-18 1956-04-17 Corman Julian Enzymatic preparation of high levulose food additives
US2841578A (en) * 1953-08-28 1958-07-01 Ohio Commw Eng Co Method for producing clinical dextran

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2841578A (en) * 1953-08-28 1958-07-01 Ohio Commw Eng Co Method for producing clinical dextran
US2742365A (en) * 1954-08-18 1956-04-17 Corman Julian Enzymatic preparation of high levulose food additives

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