GB671927A - Improvements relating to the preparation of 5-substituted 4-aminopyrimidine compounds - Google Patents

Abstract

2-Thiol-4-aminopyrimidine compounds of the general formula <FORM:0671927/IV (b)/1> are produced by condensing a substituted 2,4-dithiopyrimidine of the general formula <FORM:0671927/IV (b)/2> with ammonia or a primary amine of the formula H2NR1, where R1 is an alkyl, aryl or aralkyl group, an aryloxy group or an aryl or aralkyl group substituted by chlorine, bromine, or one or more alkyl groups containing not more than 10 carbon atoms, R is a hydrogen atom or an alkyl, aryl, or aralkyl group which contains no more than 8 carbon atoms or R and R1 may together form the arms of a cyclic system, and R1 is hydrogen or an alkyl, aryl or aralkyl group. The dithiopyrimidines employed may be obtained by the process of Specification 589,514. Preferably the amine is in excess. Examples describe the preparation of (1) 2-thiol-5-methyl-4-aminopyrimidine; (2) 2-thiol - 4,6 - diaminoquinazoline; (3) 2 - thiol-5-methyl-4-anilinopyrimidine; (4) 2-thiol-5-methyl-4-n-amylaminopyrimidine; (5) 2-thiol-5-benzyl-4-methylaminopyrimidine; (6) 2-thiol-5-phenoxy-4-aminopyrimidine; (7) 2-thiol-4-aminoquinazoline; (8) 2 - thiol - 5 - methyl - 4 - methylaminopyrimidine. Samples have been furnished under Sect. 2 (5) of (A) 2-thiol-4-amino-5-p-chlorobenzylpyrimidine, (B) 2 - thiol - 4 - amino - 5 - (31,41-dichlorophenyl)-pyrimidine prepared by heating with ammonia 2,4-dithio-5-p-chlorobenzyluracil and 2,4 - dithio - 5 (31,41 - dichlorophenyl) uracil respectively. Specification 671,926 also is referred to.