GB668761A - Improvements in or relating to the preparation of new sulphonyl derivatives of piperazine - Google Patents
Improvements in or relating to the preparation of new sulphonyl derivatives of piperazineInfo
- Publication number
- GB668761A GB668761A GB160/50A GB16050A GB668761A GB 668761 A GB668761 A GB 668761A GB 160/50 A GB160/50 A GB 160/50A GB 16050 A GB16050 A GB 16050A GB 668761 A GB668761 A GB 668761A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyl
- propyl
- tetramethylpiperazine
- preparation
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises piperazine compounds, of therapeutic value for the treatment of traumatic and haemorrhagic shock, and of the general formula <FORM:0668761/IV (b)/1> wherein R and R1 are the same or different and each represents an alkyl radical containing up to four carbon atoms (e.g. methyl, propyl, butyl or especially ethyl), and their preparation by condensing a sulphonyl halide RSO2X (where X represents halogen) with 2 : 3 : 5 : 6-tetramethylpiperazine substituted on one of the nitrogen atoms by an alkyl group of up to four carbon atoms, advantageously in the presence of an acceptor for hydrohalic acid (e.g. sodium carbonate). Examples describe the use of the following starting materials: methane- and ethane-sulphonyl chloride and propanesulphonyl bromide; 2 : 3 : 4 : 5 : 6-pentamethylpiperazine and 4-ethyl- and 4-n-propyl-2 : 3 : 5 : 6-tetramethylpiperazine. 4- Ethyl - and 4 - n - propyl - 2 : 3 : 5 : 6 - tetramethylpiperazine are obtainable by treating 2 : 3 : 5 : 6-tetramethylpyrazine with excess of ethyl and n-propyl iodide respectively and hydrogenating the resulting quaternary iodides in water in the presence of platinum.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1018277T | 1949-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB668761A true GB668761A (en) | 1952-03-19 |
Family
ID=9574966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB160/50A Expired GB668761A (en) | 1949-01-24 | 1950-01-03 | Improvements in or relating to the preparation of new sulphonyl derivatives of piperazine |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR1018277A (en) |
| GB (1) | GB668761A (en) |
-
1949
- 1949-01-24 FR FR1018277D patent/FR1018277A/en not_active Expired
-
1950
- 1950-01-03 GB GB160/50A patent/GB668761A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1018277A (en) | 1953-01-05 |
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