GB668761A - Improvements in or relating to the preparation of new sulphonyl derivatives of piperazine - Google Patents

Improvements in or relating to the preparation of new sulphonyl derivatives of piperazine

Info

Publication number
GB668761A
GB668761A GB160/50A GB16050A GB668761A GB 668761 A GB668761 A GB 668761A GB 160/50 A GB160/50 A GB 160/50A GB 16050 A GB16050 A GB 16050A GB 668761 A GB668761 A GB 668761A
Authority
GB
United Kingdom
Prior art keywords
ethyl
propyl
tetramethylpiperazine
preparation
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB160/50A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Societe des Usines Chimiques Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA, Societe des Usines Chimiques Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB668761A publication Critical patent/GB668761A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises piperazine compounds, of therapeutic value for the treatment of traumatic and haemorrhagic shock, and of the general formula <FORM:0668761/IV (b)/1> wherein R and R1 are the same or different and each represents an alkyl radical containing up to four carbon atoms (e.g. methyl, propyl, butyl or especially ethyl), and their preparation by condensing a sulphonyl halide RSO2X (where X represents halogen) with 2 : 3 : 5 : 6-tetramethylpiperazine substituted on one of the nitrogen atoms by an alkyl group of up to four carbon atoms, advantageously in the presence of an acceptor for hydrohalic acid (e.g. sodium carbonate). Examples describe the use of the following starting materials: methane- and ethane-sulphonyl chloride and propanesulphonyl bromide; 2 : 3 : 4 : 5 : 6-pentamethylpiperazine and 4-ethyl- and 4-n-propyl-2 : 3 : 5 : 6-tetramethylpiperazine. 4- Ethyl - and 4 - n - propyl - 2 : 3 : 5 : 6 - tetramethylpiperazine are obtainable by treating 2 : 3 : 5 : 6-tetramethylpyrazine with excess of ethyl and n-propyl iodide respectively and hydrogenating the resulting quaternary iodides in water in the presence of platinum.
GB160/50A 1949-01-24 1950-01-03 Improvements in or relating to the preparation of new sulphonyl derivatives of piperazine Expired GB668761A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1018277T 1949-01-24

Publications (1)

Publication Number Publication Date
GB668761A true GB668761A (en) 1952-03-19

Family

ID=9574966

Family Applications (1)

Application Number Title Priority Date Filing Date
GB160/50A Expired GB668761A (en) 1949-01-24 1950-01-03 Improvements in or relating to the preparation of new sulphonyl derivatives of piperazine

Country Status (2)

Country Link
FR (1) FR1018277A (en)
GB (1) GB668761A (en)

Also Published As

Publication number Publication date
FR1018277A (en) 1953-01-05

Similar Documents

Publication Publication Date Title
SE7602144L (en) QUATER IMIDAZOLIUM ASSOCIATIONS
GB668761A (en) Improvements in or relating to the preparation of new sulphonyl derivatives of piperazine
US2566535A (en) Quaternary ammonium salts of tertiary-aminoalkyl substituted phenylacetonitriles
GB1096351A (en) Improvements in or relating to piperazine derivatives
GB780027A (en) 3-piperidyl ethers and thioethers
ES399003A1 (en) 2-aryl-amino-imidazoline-2 compounds
GB1115986A (en) New tris(phenylthio)-s-triazine derivatives
GB845486A (en) Improvements in or relating to 2-diarylalkyl-3,4,5,6-tetrahydropyrimidines
GB1180210A (en) New Bis-Alkanolamine Derivatives and process for their Production
GB1080496A (en) Improvements in or relating to a new derivatives of 2,4,6-triiodo-3-hydroxy-benzene and process for preparing the same
GB808636A (en) Basically substituted heterocyclic compounds
US2655503A (en) Quaternary salts of y-stilbazolines
GB1021530A (en) Derivatives of 2-oxo-2h-1,4-benzoxazine
GB683141A (en) Improvements in or relating to substituted piperazines
GB1097720A (en) Method of preparing new iodinated x-ray contrast agent
GB1005022A (en) Naphthalene derivatives
GB672164A (en) A process for the manufacture of pentaenes
GB1011559A (en) Bis-quaternary ammonium salts and a process for the preparation thereof
GB1215165A (en) Quaternary ammonium-hydroxyaryl compounds, process for their manufacture and use
GB710542A (en) Improvements in derivatives of stilbazoline
GB641452A (en) Improvements in or relating to the preparation of derivatives of phenthiazine
GB1058403A (en) Improvements in or relating to novel 4-aza-thiaxanthene derivatives
GB767806A (en) New organic sulphur containing compounds
GB1059898A (en) Basically-substituted 6,11-dihydro-dibenz-[b,e]-oxepin-6-ones
GB703484A (en) New quinolinium salts