GB644915A - Lower alkyl esters of n-acylamino aliphatic carboxylic acids - Google Patents

Lower alkyl esters of n-acylamino aliphatic carboxylic acids

Info

Publication number
GB644915A
GB644915A GB15458/47A GB1545847A GB644915A GB 644915 A GB644915 A GB 644915A GB 15458/47 A GB15458/47 A GB 15458/47A GB 1545847 A GB1545847 A GB 1545847A GB 644915 A GB644915 A GB 644915A
Authority
GB
United Kingdom
Prior art keywords
prepared
acylamino
sulphite
lower alkyl
carboxylic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15458/47A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB644915A publication Critical patent/GB644915A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Lower alkyl esters, i.e. methyl, ethyl and propyl esters, of N-acylamino aliphatic carboxylic acids are prepared by heating the N-acylamino acid with about one molar equivalent of dialkyl sulphite in presence of an acidic catalyst and an alcohol having the same alkyl group as the sulphite. The quantity of acid and of alcohol required is small. N-acylglycines are prepared by treating glycines with an acyl chloride. In the examples: (1) N-n-butyrylglycine is prepared from glycine and butyryl chloride and then refluxed with dimethyl sulphite in methanolic hydrogen chloride to give the methyl ester; (2) n-caproylglycine; and (3) iso-valerylglycine are both prepared and then esterified as in example (1). The Specification as open to inspection under Sect. 91 comprises a general method for the esterification of any carboxylic acid by the method above described. This subject-matter does not appear in the Specification as accepted.
GB15458/47A 1946-07-13 1947-06-12 Lower alkyl esters of n-acylamino aliphatic carboxylic acids Expired GB644915A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US644915XA 1946-07-13 1946-07-13

Publications (1)

Publication Number Publication Date
GB644915A true GB644915A (en) 1950-10-18

Family

ID=22056357

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15458/47A Expired GB644915A (en) 1946-07-13 1947-06-12 Lower alkyl esters of n-acylamino aliphatic carboxylic acids

Country Status (1)

Country Link
GB (1) GB644915A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3305947A (en) * 1962-10-06 1967-02-28 Kalsoy Anne Sofie Julie Footwear with heavy sole parts
FR2503144A1 (en) * 1981-04-02 1982-10-08 Morelle Jean Compsns. contg. N-butyryl alpha-aminoacid(s) - for cosmetic, hygienic, therapeutic or agricultural use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3305947A (en) * 1962-10-06 1967-02-28 Kalsoy Anne Sofie Julie Footwear with heavy sole parts
FR2503144A1 (en) * 1981-04-02 1982-10-08 Morelle Jean Compsns. contg. N-butyryl alpha-aminoacid(s) - for cosmetic, hygienic, therapeutic or agricultural use

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