GB587885A - Steroid keto hydroxy acids and their polybasic acid esters and method of preparing same - Google Patents
Steroid keto hydroxy acids and their polybasic acid esters and method of preparing sameInfo
- Publication number
- GB587885A GB587885A GB16613/43A GB1661343A GB587885A GB 587885 A GB587885 A GB 587885A GB 16613/43 A GB16613/43 A GB 16613/43A GB 1661343 A GB1661343 A GB 1661343A GB 587885 A GB587885 A GB 587885A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- oxidized
- saponified
- desoxycholic
- succinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
12-Keto-steroid carboxylic acids are prepared by reacting a 3 : 12-dihydroxy substituted in the cholanic acid or a lower homologue thereof, with an anhydride or an acid chloride of a dibasic carboxylic acid, and oxidizing the partial ester so formed. If desired, the half ester may finally be saponified by treatment with alkali. The preferred dicarboxylic acids are succinic and phthalic acids. In examples: (1) Desoxycholic acid is treated with succinic acid in pyridine solution to give the 3-acid succinate which is then oxidized with cold aqueous chromic acid. Alternatively, the oxidation may be carried out with nitric acid. (2) The 3-acid succinate of nor-desoxycholic acid is prepared as in example (1) and oxidized with cold aqueous chromic acid, and finally saponified with aqueous alkali. (3) The 3-acid succinate of bisnor-desoxycholic acid is prepared in example (1) and is oxidized and saponified as in example (2). (4) Etio-desoxycholic acid is converted into its acid succinate, oxidized and saponified as in example (2). The Specification as open to inspection under Sect. 91 includes also the use as a starting material of any 3 : 12-dihydroxy-steroid compound substituted in the 17-position by a carboxylic acid group or a hydrocarbon chain terminated by a carboxylic acid group. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US587885XA | 1942-09-26 | 1942-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB587885A true GB587885A (en) | 1947-05-12 |
Family
ID=22018927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB16613/43A Expired GB587885A (en) | 1942-09-26 | 1943-10-11 | Steroid keto hydroxy acids and their polybasic acid esters and method of preparing same |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB587885A (en) |
-
1943
- 1943-10-11 GB GB16613/43A patent/GB587885A/en not_active Expired
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