GB561571A - ª‰-(2,5-dimethoxyphenyl)-ª‰-hydroxyisopropylamine - Google Patents
ª‰-(2,5-dimethoxyphenyl)-ª‰-hydroxyisopropylamineInfo
- Publication number
- GB561571A GB561571A GB16987/42A GB1698742A GB561571A GB 561571 A GB561571 A GB 561571A GB 16987/42 A GB16987/42 A GB 16987/42A GB 1698742 A GB1698742 A GB 1698742A GB 561571 A GB561571 A GB 561571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- stage
- dimethoxyphenyl
- ketoisopropylamine
- isonitrosopropiophenone
- dimethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
b -(2 : 5 -dimethoxyphenyl)-b -hydroxyisopropylamine is prepared by a two-stage reduction of 2 : 5-dimethoxy-a -isonitrosopropiophenone using a palladized charcoal catalyst for the first stage and a platinum catalyst for the second stage. The first stage in the reduction results in the formation of the ketoisopropylamine. In an example, 2 : 5-dimethoxypropiophenone is treated in ether solution with methyl nitrite and hydrogen chloride to form 2 : 5-dimethoxy-a -isonitrosopropiophenone. This is dissolved in absolute alcohol containing hydrogen chloride and hydrogenated in the presence of palladized charcoal to form b -(2 : 5-dimethoxyphenyl)-b -ketoisopropylamine hydrochloride, which on further hydrogenation in aqueous solution in presence of platinum oxide gives the required b -(2 : 5-dimethoxyphenyl) - b -hydroxyisopro - pylamine. Acetylation with acetic anhydride gives the diacetyl derivative. The compounds of the present invention act as a powerful, long acting pressor and mydriatic.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US561571XA | 1942-06-24 | 1942-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB561571A true GB561571A (en) | 1944-05-24 |
Family
ID=22002545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB16987/42A Expired GB561571A (en) | 1942-06-24 | 1942-11-30 | ª‰-(2,5-dimethoxyphenyl)-ª‰-hydroxyisopropylamine |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB561571A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3028429A (en) * | 1959-09-24 | 1962-04-03 | Nepera Chemical Co Inc | Method of producing 2-amino-1-phenyl-1-propanol hydrochloride |
-
1942
- 1942-11-30 GB GB16987/42A patent/GB561571A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3028429A (en) * | 1959-09-24 | 1962-04-03 | Nepera Chemical Co Inc | Method of producing 2-amino-1-phenyl-1-propanol hydrochloride |
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