GB545360A - Improvements in or relating to the preparation of tetraacylated ribonyl derivatives - Google Patents

Improvements in or relating to the preparation of tetraacylated ribonyl derivatives

Info

Publication number
GB545360A
GB545360A GB16712/40A GB1671240A GB545360A GB 545360 A GB545360 A GB 545360A GB 16712/40 A GB16712/40 A GB 16712/40A GB 1671240 A GB1671240 A GB 1671240A GB 545360 A GB545360 A GB 545360A
Authority
GB
United Kingdom
Prior art keywords
tetra
acid
ribonyl
ribose
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16712/40A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charles Pfizer and Co Inc filed Critical Charles Pfizer and Co Inc
Publication of GB545360A publication Critical patent/GB545360A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)

Abstract

545,360. Ribonyl derivatives. PFIZER & CO., C. Nov. 20, 1940, No. 16712. Convention date, Dec. 16, 1939. [Class 2 (iii)] Tetra-acylated ribonyl derivatives including tetra-acylated ribose in the aldehyde form are prepared by tetra-acylating ribonamide, treating this with nitrous anhydride to form tetraacylated ribonic acid, forming the acid chloride, and finally reducing to the free aldehyde ribose. The d-ribonaniide which forms the starting material for the series of reactions is preferably prepared by treating d-ribonolactone in alcohol solution with dry ammonia. In an example d-ribonamide is treated with acetic anhydride in pyridine solution to form tetra-acetyl-dribonamide which is then dissolved in glacial acetic acid or treated with the gas obtained by reacting sodium nitrite with excess of sulphuric acid. On removing the acetic acid, tetraacetyl-d-ribonic acid is isolated. The corresponding acid chloride which is obtained by reaction with phosphorus pentachloride in chloroform solution, is then reduced by hydrogen in the presence of a Pd-Ba SO catalyst in xylene solution to form tetra-acetyl-d-ribose.
GB16712/40A 1939-12-16 1940-11-20 Improvements in or relating to the preparation of tetraacylated ribonyl derivatives Expired GB545360A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US545360XA 1939-12-16 1939-12-16

Publications (1)

Publication Number Publication Date
GB545360A true GB545360A (en) 1942-05-21

Family

ID=21991783

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16712/40A Expired GB545360A (en) 1939-12-16 1940-11-20 Improvements in or relating to the preparation of tetraacylated ribonyl derivatives

Country Status (1)

Country Link
GB (1) GB545360A (en)

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