GB535430A - Process for the manufacture of 2,4-dioxo-3,3-dialkyl-pyrrolidines - Google Patents

Process for the manufacture of 2,4-dioxo-3,3-dialkyl-pyrrolidines

Info

Publication number
GB535430A
GB535430A GB29312/39A GB2931239A GB535430A GB 535430 A GB535430 A GB 535430A GB 29312/39 A GB29312/39 A GB 29312/39A GB 2931239 A GB2931239 A GB 2931239A GB 535430 A GB535430 A GB 535430A
Authority
GB
United Kingdom
Prior art keywords
propyl
esters
dioxo
ester
pyrrolidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29312/39A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB535430A publication Critical patent/GB535430A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Abstract

535,430. Pyrrolidines. HOFFMANN-LA ROCHE & CO. AKT.-GES. F. Nov. 3, 1939, No. 29312. Convention date, Nov. 30, 1938. [Class 2 (iii)] 2:4-Dioxo-3:3-dialkylpyrrolidines, in which the alkyl groups each contain at least two carbon atoms, are prepared by reacting a:adialkyl-y-halogenacetoacetic esters with ammonia in a solvent. The products possess therapeutic properties. Examples describe the preparation of 3:3-diethyl-, 3-n-propyl-3- isobutyl- and 3-n-propyl-3-n-hexyl-2:4-dioxopyrrolidines from the corresponding α:α-disubstituted-γ-bromoacetoacetic esters, and 3:3- di-n-propyl-2:4-dioxo-pyrrolidine from α:α-di-npropyl-γ-chloracetoacetic ester. Of the α:α-dialkyl-γ-halogenacetoacetic esters, the α:α-di-n-propyl compound above is prepared by treating α:α-di-n-propylacetoacetic ester with sulphuryl chloride, and the remaining two esters by reacting α-n-propylacetoacetic ester with isobutyl bromide and n-propyl bromide respectively and brominating with bromine.
GB29312/39A 1938-11-30 1939-11-03 Process for the manufacture of 2,4-dioxo-3,3-dialkyl-pyrrolidines Expired GB535430A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE535430X 1938-11-30

Publications (1)

Publication Number Publication Date
GB535430A true GB535430A (en) 1941-04-09

Family

ID=6556884

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29312/39A Expired GB535430A (en) 1938-11-30 1939-11-03 Process for the manufacture of 2,4-dioxo-3,3-dialkyl-pyrrolidines

Country Status (1)

Country Link
GB (1) GB535430A (en)

Similar Documents

Publication Publication Date Title
GB1333471A (en) Imidazoline derivatives and process for preparing the same
GB547874A (en) Manufacture of insecticidal compositions, and the resulting products
GB1307809A (en) Capronylhydroxy-benzoic acid esters their use as nematogenic compounds and nematogenic mixtures containing them
GB535430A (en) Process for the manufacture of 2,4-dioxo-3,3-dialkyl-pyrrolidines
FR870222A (en) Process for the preparation of nitrogenous polymer compounds and products obtained by this process
GB1369795A (en) Process for preparing methacrylate esters of phenol derivatives
GB1408150A (en) Process for preparing polyesters
GB1358948A (en) Process for the manufacture of cycloalkenone esters
GB750440A (en) Improvements in or relating to the production of sodium bicarbonate and ammonium chloride
ES417396A1 (en) A procedure for the production of a pharmaceutical composition. (Machine-translation by Google Translate, not legally binding)
ES428969A1 (en) 2,2,2-Trifluoro-1-chloroethyl ethers and process for preparing them
FR883930A (en) Process for preparing acetylsulfanilic acid chloride
GB1143930A (en) Process for the preparation of an acid fluoride and of corresponding esters
GB450592A (en) Process for the manufacture of polymerisation products of olefines
ES443462A1 (en) Deacetoxycephalosporins via penicillin sulfoxide rearrangement
FR974085A (en) Process for the preparation of nitrogenous derivatives of carbonic acid
ES471125A1 (en) 1-Substituted aminoindolines, process for their production and pharmaceutical compositions containing them.
DE3062840D1 (en) 10-bromosandwicine and 10-bromoisosandwicine, as well as their additions salts with pharmacolical acceptable acids process for their preparation and their use
GB510167A (en) Manufacture of 3-hydroxy-4-carbaminobenzene-1-arsonic acid
GB1134314A (en) New carbonic acid esters
GB1467528A (en) Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate
GB1325944A (en) Bisoxalic acid diamides
FR735765A (en) Process for the preparation of n-chlorosulfonylamides, n-chlorosulfonylsulfonamides and aryl chlorosulfonates as well as aminosulfonamides
GB518149A (en) Improvements relating to the manufacture of ethylene derivatives
GB665315A (en) Phosphorous-containing derivatives of m-aminophenols and process for the manufactureof same