GB496738A - The manufacture of pyrimidine compounds - Google Patents

The manufacture of pyrimidine compounds

Info

Publication number
GB496738A
GB496738A GB17092/38A GB1709238A GB496738A GB 496738 A GB496738 A GB 496738A GB 17092/38 A GB17092/38 A GB 17092/38A GB 1709238 A GB1709238 A GB 1709238A GB 496738 A GB496738 A GB 496738A
Authority
GB
United Kingdom
Prior art keywords
methyl
pyrimidine
ethoxypropionate
ethoxymethyl
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17092/38A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp
Original Assignee
Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp filed Critical Research Corp
Publication of GB496738A publication Critical patent/GB496738A/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2-Methyl-5-ethoxymethyl or bromomethyl-6-amino-pyrimidine is prepared by hydrolysing b -ethoxypropionitrile in the presence of alcohol, condensing the resulting ethyl b -ethoxypropionate with formic ester in the presence of sodium, reacting the sodio-formyl-ethyl-b -ethoxypropionate so formed with acetamidine hydrochloride in the presence of sodium alcoholate, chlorinating the 2-methyl-5-ethoxy-methyl-6-hydroxypyrimidine with phosphorus oxychloride, treating the product with alcoholic ammonia under pressure, and finally, if desired, reacting the 2-methyl-5-ethoxymethyl-6-amino-pyrimidine with hydrobromic acid to replace the ethoxy group by bromine. The products are useful in the preparation of Vitamin B1. Examples are given relating to each of the steps of the process and of the conversion of the final process into its hydrobromide. Specification 473,193 is referred to.
GB17092/38A 1936-06-15 1937-06-02 The manufacture of pyrimidine compounds Expired GB496738A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US496738XA 1936-06-15 1936-06-15

Publications (1)

Publication Number Publication Date
GB496738A true GB496738A (en) 1938-12-02

Family

ID=21961061

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17092/38A Expired GB496738A (en) 1936-06-15 1937-06-02 The manufacture of pyrimidine compounds

Country Status (1)

Country Link
GB (1) GB496738A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492792A (en) * 1982-02-04 1985-01-08 Ube Industries, Ltd. Process for preparing 4-amino-5-dialkoxy-methylpyrimidine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492792A (en) * 1982-02-04 1985-01-08 Ube Industries, Ltd. Process for preparing 4-amino-5-dialkoxy-methylpyrimidine derivatives

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