GB491653A - Process for the separation of the anti-rachitically acting components of irradiated 7-dehydrocholesterol - Google Patents

Process for the separation of the anti-rachitically acting components of irradiated 7-dehydrocholesterol

Info

Publication number
GB491653A
GB491653A GB6653/37A GB665337A GB491653A GB 491653 A GB491653 A GB 491653A GB 6653/37 A GB6653/37 A GB 6653/37A GB 665337 A GB665337 A GB 665337A GB 491653 A GB491653 A GB 491653A
Authority
GB
United Kingdom
Prior art keywords
vitamin
irradiated
dehydrocholesterol
schedule
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6653/37A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FRITZ MERCK
Original Assignee
FRITZ MERCK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FRITZ MERCK filed Critical FRITZ MERCK
Publication of GB491653A publication Critical patent/GB491653A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The antirachitically active component is separated from irradiated 7-dehydrocholesterol by steps comprising esterification of the irradiated product, separating the mixed esters by differential solution, saponifying the portion containing the active ingredient and at any stage, i.e. before esterification, in the esterified form or after saponification, effecting a purification by the method of chromatographic adsorption. The crude irradiation products may be first purified by treatment with maleic anhydride or its homologues (e.g. citraconic anhydride) to produce the ester which is separated and saponified. Suitable esterifying groups for combination with the vitamin, (referred to as vitamin D3) in order to form relatively sparingly soluble esters are allophanic acid (the ester is prepared by leading cyanic acid gas into the solution of the material) and 3-5-dinitrobenzoic acid or its 4-methyl derivative. Detailed descriptions of preparation of the vitamin are described in an example and in the schedule to a sample filed under Sect. 2 (5). The Specification as open to inspection under Sect. 91 includes examples and the schedule to a sample in which the step of chromatographic adsorption is not included. This subject-matter does not appear in the Specification as accepted.
GB6653/37A 1936-03-06 1937-03-06 Process for the separation of the anti-rachitically acting components of irradiated 7-dehydrocholesterol Expired GB491653A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE491653X 1936-03-06

Publications (1)

Publication Number Publication Date
GB491653A true GB491653A (en) 1938-09-06

Family

ID=6544301

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6653/37A Expired GB491653A (en) 1936-03-06 1937-03-06 Process for the separation of the anti-rachitically acting components of irradiated 7-dehydrocholesterol

Country Status (1)

Country Link
GB (1) GB491653A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529546A (en) * 1983-05-26 1985-07-16 Basf Aktiengesellschaft Purification of vitamin D3

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529546A (en) * 1983-05-26 1985-07-16 Basf Aktiengesellschaft Purification of vitamin D3

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