GB430282A - The manufacture of new alkylated 5:5-phenylethyl-hydantoins - Google Patents

The manufacture of new alkylated 5:5-phenylethyl-hydantoins

Info

Publication number
GB430282A
GB430282A GB2345934A GB2345934A GB430282A GB 430282 A GB430282 A GB 430282A GB 2345934 A GB2345934 A GB 2345934A GB 2345934 A GB2345934 A GB 2345934A GB 430282 A GB430282 A GB 430282A
Authority
GB
United Kingdom
Prior art keywords
benzyl
hydantoin
methyl
phenylethyl
chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2345934A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to GB2345934A priority Critical patent/GB430282A/en
Publication of GB430282A publication Critical patent/GB430282A/en
Expired legal-status Critical Current

Links

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Phenyl ethyl hydantoins having a methyl group attached to one nitrogen atom and a benzyl or substituted benzyl group attached to the other nitrogen atom are prepared by methylating or benzylating the corresponding mono-substituted hydantoin by means of suitable agents such as methyl chloride, dimethyl sulphate, benzyl chloride and nitrobenzyl chloride. The reaction is preferably effected in the presence of a solvent or diluent and of an acid-binding substance. In examples (1) 3 - benzyl - 5 - 5 phenyl ethyl hydantoin obtained by benzylating the phenylethyl hydantoin, is dissolved in hot ethanol, and caustic soda is added; the mixture is then treated with dimethyl sulphate at 55--75 DEG C. with stirring. (2) 1 - Benzyl - 5 - 5 - phenylethyl hydantoin, obtained by treating phenylethylbenzylureidoacetonitrile with an acid, is dissolved in aqueous caustic soda, and treated with dimethyl sulphate at 50 DEG C. with stirring. Alternatively the starting compound may be N-methyl or N-benzyl-5-phenyl hydantoin, the N - methyl - N - benzyl derivative being then ethylated to produce the 5-5-phenyl ethyl derivative.
GB2345934A 1933-12-15 1933-12-15 The manufacture of new alkylated 5:5-phenylethyl-hydantoins Expired GB430282A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2345934A GB430282A (en) 1933-12-15 1933-12-15 The manufacture of new alkylated 5:5-phenylethyl-hydantoins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2345934A GB430282A (en) 1933-12-15 1933-12-15 The manufacture of new alkylated 5:5-phenylethyl-hydantoins

Publications (1)

Publication Number Publication Date
GB430282A true GB430282A (en) 1935-06-17

Family

ID=10195962

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2345934A Expired GB430282A (en) 1933-12-15 1933-12-15 The manufacture of new alkylated 5:5-phenylethyl-hydantoins

Country Status (1)

Country Link
GB (1) GB430282A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3209009A (en) * 1965-09-28 Pons ctal

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3209009A (en) * 1965-09-28 Pons ctal

Similar Documents

Publication Publication Date Title
GB430282A (en) The manufacture of new alkylated 5:5-phenylethyl-hydantoins
Cook et al. 50. Studies in the azole series. Part III. The interaction of aminoacetonitrile and carbon disulphide
GOLUMBIC et al. CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES. 1 II. THE COMPOSITION OF AGED UNBUFFERED SOLUTIONS OF METHYL-BIS (β-CHLOROETHYL) AMINE
SU433680A3 (en)
GB856409A (en) Improvements in and relating to a new pyridazine derivative and its process of preparation
US2265207A (en) D-lysergic acid - d - l-bjtdroxybutyl
SU604497A3 (en) Method of preparing tetramyzole or salts thereof
Cambron et al. The oxidation of xanthates and some new dialkyl sulphur-and disulphur-dicarbothionates
Hodgson et al. 260. The replacement of the diazonium by the nitro-group. Part III. Decompositions by cupro-cupri sulphite
GB986579A (en) 5-ethylidene dibenzocycloheptadienes and the preparation thereof
GB796996A (en) Imidazole derivatives
GB1070139A (en) Novel imidazothiazole derivatives and a process for preparation thereof
US2616895A (en) Iminodibenzyl derivative
GB672164A (en) A process for the manufacture of pentaenes
US3239526A (en) 3-phenyl-4-aminocinnolines
GB937879A (en) New pyrazole-carboxylic acid hydrazides
GB679894A (en) Production of thiosemicarbazones
GB934577A (en) Preparation of 3-(trifluoromethyl)-phenols
US2086311A (en) S-cyclohexenylalkylhydantoins
GB706409A (en) Process for the preparation of diethylaminoaceto-2m-xylidide
GB666578A (en) Process for the preparation of derivatives of 1, 2, 3 substituted pyrazolones and derivatives obtained by this process
GB454423A (en) Manufacture of anthraquinone compounds containing nitrogen
GB414768A (en) Process for the manufacture of stable diazonium compounds
GB595177A (en) Improvements in or relating to the manufacture of substituted sulphonamido compounds
GB669016A (en) N-benzhydryl-n-acyl-ureas and process for the manufacture of same