GB328347A - Manufacture of therapeutic substances from the pituitary gland - Google Patents

Manufacture of therapeutic substances from the pituitary gland

Info

Publication number
GB328347A
GB328347A GB3841/29A GB384129A GB328347A GB 328347 A GB328347 A GB 328347A GB 3841/29 A GB3841/29 A GB 3841/29A GB 384129 A GB384129 A GB 384129A GB 328347 A GB328347 A GB 328347A
Authority
GB
United Kingdom
Prior art keywords
precipitate
solution
aqueous
activity
cresol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3841/29A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VICTOR JOHN WARD
Wellcome Foundation Ltd
Original Assignee
VICTOR JOHN WARD
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VICTOR JOHN WARD, Wellcome Foundation Ltd filed Critical VICTOR JOHN WARD
Priority to GB3841/29A priority Critical patent/GB328347A/en
Publication of GB328347A publication Critical patent/GB328347A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

328,347. Wellcome Foundation, Ltd., Smith, S., and Ward, V. J. Feb. 5, 1929. Medicines for internal use.-The active principles of the posterior lobe of the pituitary gland are purified and fractionally separated by employ. ing phenol or cresol, or solutions thereof in alcohol or like solvent as an extracting medium for the glands, or as a solvent for the material salted out from an aqueous extract of the gland by means of ammonium sulphate, or for active protein matter obtained by adding picric, picrolonic or flavianic acid to an aqueous pituitary extract, grinding the precipitate so produced with alcoholic hydrochloric acid and pouring the turbid mixture into acetone to obtain a precipitate. The solution of active materials obtained by any of the above methods is poured into a mixture of ether and light petroleum to obtain a precipitate having relatively great oxytocic and pressor activity. This precipitate is again dissolved in phenol, cresol, or an alcoholic solution thereof and the solution is treated first with ether to give a precipitate having great pressor activity, and then, after saturation with water, with light petroleum to throw down an aqueous layer having substantially only oxytocic activity.
GB3841/29A 1929-02-05 1929-02-05 Manufacture of therapeutic substances from the pituitary gland Expired GB328347A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3841/29A GB328347A (en) 1929-02-05 1929-02-05 Manufacture of therapeutic substances from the pituitary gland

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3841/29A GB328347A (en) 1929-02-05 1929-02-05 Manufacture of therapeutic substances from the pituitary gland

Publications (1)

Publication Number Publication Date
GB328347A true GB328347A (en) 1930-05-01

Family

ID=9765928

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3841/29A Expired GB328347A (en) 1929-02-05 1929-02-05 Manufacture of therapeutic substances from the pituitary gland

Country Status (1)

Country Link
GB (1) GB328347A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844511A (en) * 1956-11-14 1958-07-22 Merck & Co Inc Process for preparing improved acth

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844511A (en) * 1956-11-14 1958-07-22 Merck & Co Inc Process for preparing improved acth

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