GB2578093B - Liquid pharmaceutical composition comprising RPL554 and HFA-134A - Google Patents

Liquid pharmaceutical composition comprising RPL554 and HFA-134A Download PDF

Info

Publication number
GB2578093B
GB2578093B GB1816447.5A GB201816447A GB2578093B GB 2578093 B GB2578093 B GB 2578093B GB 201816447 A GB201816447 A GB 201816447A GB 2578093 B GB2578093 B GB 2578093B
Authority
GB
United Kingdom
Prior art keywords
rpl554
hfa
pharmaceutical composition
liquid pharmaceutical
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1816447.5A
Other languages
English (en)
Other versions
GB201816447D0 (en
GB2578093A (en
Inventor
Lionel Spargo Peter
A Haywood Philip
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verona Pharma Ltd
Original Assignee
Verona Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verona Pharma Ltd filed Critical Verona Pharma Ltd
Priority to GB1816447.5A priority Critical patent/GB2578093B/en
Publication of GB201816447D0 publication Critical patent/GB201816447D0/en
Priority to AU2019358585A priority patent/AU2019358585B2/en
Priority to EP19790718.1A priority patent/EP3820446B1/en
Priority to SM20220044T priority patent/SMT202200044T1/it
Priority to RS20211599A priority patent/RS62775B1/sr
Priority to HUE19790718A priority patent/HUE057780T2/hu
Priority to PCT/GB2019/052863 priority patent/WO2020074894A1/en
Priority to CN201980065895.8A priority patent/CN112912064B/zh
Priority to EP21198029.7A priority patent/EP3960157A1/en
Priority to JP2021517866A priority patent/JP7578587B2/ja
Priority to PT197907181T priority patent/PT3820446T/pt
Priority to US17/280,452 priority patent/US20210379053A1/en
Priority to SI201930145T priority patent/SI3820446T1/sl
Priority to LTEPPCT/GB2019/052863T priority patent/LT3820446T/lt
Priority to HRP20220053TT priority patent/HRP20220053T1/hr
Priority to BR112021006712-4A priority patent/BR112021006712A2/pt
Priority to ES19790718T priority patent/ES2899744T3/es
Priority to KR1020217010706A priority patent/KR20210073532A/ko
Priority to DK19790718.1T priority patent/DK3820446T3/da
Priority to MX2021003599A priority patent/MX2021003599A/es
Priority to PL19790718T priority patent/PL3820446T3/pl
Priority to CA3113167A priority patent/CA3113167A1/en
Priority to MYPI2021001479A priority patent/MY207302A/en
Priority to SG11202102567UA priority patent/SG11202102567UA/en
Publication of GB2578093A publication Critical patent/GB2578093A/en
Application granted granted Critical
Publication of GB2578093B publication Critical patent/GB2578093B/en
Priority to ZA2021/02039A priority patent/ZA202102039B/en
Priority to MX2024001499A priority patent/MX2024001499A/es
Priority to IL282032A priority patent/IL282032B1/en
Priority to PH12021550767A priority patent/PH12021550767A1/en
Priority to CY20221100086T priority patent/CY1124943T1/el
Priority to US18/616,878 priority patent/US20250049781A1/en
Priority to JP2024091837A priority patent/JP7836853B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB1816447.5A 2018-10-09 2018-10-09 Liquid pharmaceutical composition comprising RPL554 and HFA-134A Active GB2578093B (en)

Priority Applications (31)

Application Number Priority Date Filing Date Title
GB1816447.5A GB2578093B (en) 2018-10-09 2018-10-09 Liquid pharmaceutical composition comprising RPL554 and HFA-134A
ES19790718T ES2899744T3 (es) 2018-10-09 2019-10-09 Formulación
KR1020217010706A KR20210073532A (ko) 2018-10-09 2019-10-09 흡입에 의한 투여를 위한 hfa-134a 내의 rpl554를 포함하는 약제학적 조성물
SM20220044T SMT202200044T1 (it) 2018-10-09 2019-10-09 Composizioni farmaceutiche comprendendo rpl554 in hfa-134a per somministrazione mediante inalazione
RS20211599A RS62775B1 (sr) 2018-10-09 2019-10-09 Farmaceutske kompozicije koje sadrže rpl554 u hfa-134a za davanje inhalacijom
HUE19790718A HUE057780T2 (hu) 2018-10-09 2019-10-09 HFA 134A-ban oldott RPL554-t tartalmazó gyógyszerkészítmény belégzés útján történõ adagolásra
PCT/GB2019/052863 WO2020074894A1 (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
CN201980065895.8A CN112912064B (zh) 2018-10-09 2019-10-09 用于通过吸入给药的包含rpl554的hfa-134a溶液的药物组合物
EP21198029.7A EP3960157A1 (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
JP2021517866A JP7578587B2 (ja) 2018-10-09 2019-10-09 Ｈｆａ－１３４ａ中のｒｐｌ５５４を含む吸入による投与用医薬組成物
PT197907181T PT3820446T (pt) 2018-10-09 2019-10-09 Composições farmacêuticas que compreendem rpl554 em hfa-134a para administração mediante inalação
US17/280,452 US20210379053A1 (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
SI201930145T SI3820446T1 (sl) 2018-10-09 2019-10-09 Farmacevtski sestavki, ki vsebujejo RPL554 v HFA-134A za uporabo z vdihavanjem
LTEPPCT/GB2019/052863T LT3820446T (lt) 2018-10-09 2019-10-09 Farmacinės kompozicijos, apimančios rpl554 hfa-134a terpėje, skirtos įvesti inhaliuojant
HRP20220053TT HRP20220053T1 (hr) 2018-10-09 2019-10-09 Farmaceutski sastavi koji sadrže rpl554 u hfa-134a za primjenu inhalacijom
BR112021006712-4A BR112021006712A2 (pt) 2018-10-09 2019-10-09 composição farmacêutica líquida, inalador pressurizado dosimetrado e método de tratamento ou prevenção
AU2019358585A AU2019358585B2 (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising RPL554 in HFA-134a for administration by inhalation
DK19790718.1T DK3820446T3 (da) 2018-10-09 2019-10-09 Farmaceutiske sammensætninger omfattende RPL554 I HFA-134A til indgivelse ved inhalation
EP19790718.1A EP3820446B1 (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
MX2021003599A MX2021003599A (es) 2018-10-09 2019-10-09 Composiciones farmaceuticas que comprenden 9,10-dimetoxi-2-(2,4,6- trimetilfenilimino)-3-(n-carbamoil-2-aminoetil)-3,4,6,7-tetrahidr o-2h-pirimido[6,1-a]isoquinolin-4-ona (rpl554) en 1,1,1,2-tetrafluoroetano (hfa-134a) para administracion por inhalacion.
PL19790718T PL3820446T3 (pl) 2018-10-09 2019-10-09 Kompozycje farmaceutyczne zawierające rpl554 w hfa-134a do podawania przez inhalację
CA3113167A CA3113167A1 (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
MYPI2021001479A MY207302A (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
SG11202102567UA SG11202102567UA (en) 2018-10-09 2019-10-09 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
ZA2021/02039A ZA202102039B (en) 2018-10-09 2021-03-25 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
MX2024001499A MX2024001499A (es) 2018-10-09 2021-03-26 Composiciones farmacéuticas que comprenden 9,10-dimetoxi-2-(2,4,6- trimetilfenilimino)-3-(n-carbamoil-2-aminoetil)-3,4,6,7-tetrahidr o-2h-pirimido[6,1-a]isoquinolin-4-ona (rpl554) en 1,1,1,2-tetrafluoroetano (hfa-134a) para administración por inhalación.
IL282032A IL282032B1 (en) 2018-10-09 2021-04-04 Pharmaceutical preparations containing rpl554 in hfa-134a for administration by inhalation
PH12021550767A PH12021550767A1 (en) 2018-10-09 2021-04-06 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
CY20221100086T CY1124943T1 (el) 2018-10-09 2022-02-02 Φαρμακευτικες συνθεσεις που περιλαμβανουν rpl554 σε hfa-134a για χορηγηση με εισπνοη
US18/616,878 US20250049781A1 (en) 2018-10-09 2024-03-26 Pharmaceutical compositions comprising rpl554 in hfa-134a for administration by inhalation
JP2024091837A JP7836853B2 (ja) 2018-10-09 2024-06-05 Ｈｆａ－１３４ａ中のｒｐｌ５５４を含む吸入による投与用医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1816447.5A GB2578093B (en) 2018-10-09 2018-10-09 Liquid pharmaceutical composition comprising RPL554 and HFA-134A

Publications (3)

Publication Number Publication Date
GB201816447D0 GB201816447D0 (en) 2018-11-28
GB2578093A GB2578093A (en) 2020-04-22
GB2578093B true GB2578093B (en) 2020-11-18

Family

ID=64394831

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1816447.5A Active GB2578093B (en) 2018-10-09 2018-10-09 Liquid pharmaceutical composition comprising RPL554 and HFA-134A

Country Status (27)

Country Link
US (2) US20210379053A1 (https=)
EP (2) EP3820446B1 (https=)
JP (2) JP7578587B2 (https=)
KR (1) KR20210073532A (https=)
CN (1) CN112912064B (https=)
AU (1) AU2019358585B2 (https=)
BR (1) BR112021006712A2 (https=)
CA (1) CA3113167A1 (https=)
CY (1) CY1124943T1 (https=)
DK (1) DK3820446T3 (https=)
ES (1) ES2899744T3 (https=)
GB (1) GB2578093B (https=)
HR (1) HRP20220053T1 (https=)
HU (1) HUE057780T2 (https=)
IL (1) IL282032B1 (https=)
LT (1) LT3820446T (https=)
MX (2) MX2021003599A (https=)
MY (1) MY207302A (https=)
PH (1) PH12021550767A1 (https=)
PL (1) PL3820446T3 (https=)
PT (1) PT3820446T (https=)
RS (1) RS62775B1 (https=)
SG (1) SG11202102567UA (https=)
SI (1) SI3820446T1 (https=)
SM (1) SMT202200044T1 (https=)
WO (1) WO2020074894A1 (https=)
ZA (1) ZA202102039B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3142701T3 (en) 2014-05-12 2018-08-13 Verona Pharma Plc New treatment
GB201502260D0 (en) 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
GB201916915D0 (en) 2019-11-20 2020-01-01 Amr Centre Ltd Compounds
GB2594480A (en) * 2020-04-28 2021-11-03 Verona Pharma Plc New treatment
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
WO2024088364A1 (zh) * 2022-10-28 2024-05-02 江苏恒瑞医药股份有限公司 一种包含异喹啉酮类化合物的药物组合物及其制备方法
EP4378942A1 (en) 2022-12-02 2024-06-05 Sandoz AG Crystal form of a pde3/4 inhibitor
CN121620356A (zh) 2023-06-26 2026-03-06 维罗纳制药公司 包含恩塞芬汀的颗粒组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014140647A1 (en) * 2013-03-15 2014-09-18 Verona Pharma Plc Drug combination
WO2015173551A1 (en) * 2014-05-12 2015-11-19 Verona Pharma Plc New treatment
WO2016042313A1 (en) * 2014-09-15 2016-03-24 Verona Pharma Plc Liquid inhalation formulation comprising rpl554
WO2016128742A1 (en) * 2015-02-11 2016-08-18 Verona Pharma Plc Salt of a pyrimido[6,1-a]isoquinolin-4-one compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2208310T3 (es) 1999-03-31 2004-06-16 Vernalis Limited Derivados de pirimido(6,1-a) isoquinolin-4-ona.
PH12013500261A1 (en) * 2010-08-09 2013-03-04 Verona Pharma Plc Crystalline form of pyrimidio[6,1-a]isoquinolin-4-one compound
EP2819645A2 (en) * 2012-02-28 2015-01-07 Iceutica Holdings Inc. Bvi Inhalable pharmaceutical compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014140647A1 (en) * 2013-03-15 2014-09-18 Verona Pharma Plc Drug combination
WO2015173551A1 (en) * 2014-05-12 2015-11-19 Verona Pharma Plc New treatment
WO2016042313A1 (en) * 2014-09-15 2016-03-24 Verona Pharma Plc Liquid inhalation formulation comprising rpl554
WO2016128742A1 (en) * 2015-02-11 2016-08-18 Verona Pharma Plc Salt of a pyrimido[6,1-a]isoquinolin-4-one compound

Also Published As

Publication number Publication date
DK3820446T3 (da) 2021-12-06
JP7578587B2 (ja) 2024-11-06
JP7836853B2 (ja) 2026-03-27
AU2019358585A1 (en) 2021-04-15
KR20210073532A (ko) 2021-06-18
MX2024001499A (es) 2024-02-27
BR112021006712A2 (pt) 2021-07-27
IL282032B1 (en) 2026-01-01
HRP20220053T1 (hr) 2022-04-15
SG11202102567UA (en) 2021-04-29
CN112912064A (zh) 2021-06-04
GB201816447D0 (en) 2018-11-28
AU2019358585B2 (en) 2025-01-16
US20250049781A1 (en) 2025-02-13
EP3820446B1 (en) 2021-11-03
EP3960157A1 (en) 2022-03-02
US20210379053A1 (en) 2021-12-09
IL282032A (en) 2021-05-31
PT3820446T (pt) 2021-12-03
SI3820446T1 (sl) 2022-01-31
CA3113167A1 (en) 2020-04-16
LT3820446T (lt) 2021-12-10
EP3820446A1 (en) 2021-05-19
SMT202200044T1 (it) 2022-05-12
ES2899744T3 (es) 2022-03-14
JP2024113096A (ja) 2024-08-21
JP2022513566A (ja) 2022-02-09
CN112912064B (zh) 2025-02-14
MY207302A (en) 2025-02-15
RS62775B1 (sr) 2022-01-31
MX2021003599A (es) 2021-05-28
GB2578093A (en) 2020-04-22
PH12021550767A1 (en) 2021-10-04
HUE057780T2 (hu) 2022-06-28
ZA202102039B (en) 2022-08-31
WO2020074894A1 (en) 2020-04-16
CY1124943T1 (el) 2023-01-05
PL3820446T3 (pl) 2022-03-14

Similar Documents

Publication Publication Date Title
ES3063733T3 (en) Pharmaceutical combination comprising tno155 and ribociclib
GB2578093B (en) Liquid pharmaceutical composition comprising RPL554 and HFA-134A
HUE052749T2 (hu) Meloxicamot és rizatriptant tartalmazó gyógyászati készítmények
IL263082B (en) New compounds as ototaxin inhibitors and pharmaceutical preparations containing them
EP3706741A4 (en) PHARMACEUTICAL COMPOSITION AND USE THEREOF
ZA201900772B (en) Heterodimeric fc-fused cytokine and pharmaceutical composition comprising the same
IL269061A (en) A pharmaceutical preparation containing Selexifag
HUE067772T2 (hu) Folyékony kompozíció és berendezés
ZA201907313B (en) Stable liquid pharmaceutical composition
EP3714901A4 (en) ANTI-LAG-3 ANTIBODY PHARMACEUTICAL COMPOSITION AND USE THEREOF
EP3697411A4 (en) NEW PHARMACEUTICAL COMPOSITION AND ITS USE
IL281357B (en) cd73 inhibitors and their pharmaceutical uses
GB201807053D0 (en) Pharmaceutical composition
EP3275453A4 (en) Pharmaceutical composition containing silybin and ve
IL276323A (en) 4-Methyldihydropyrimidinone compounds and their pharmaceutical use
ZA202006541B (en) Pharmaceutical composition comprising brexpiprazole
PL3525769T3 (pl) Tabletka ulegająca rozpadowi w jamie ustnej zawierająca burlulipazę i wytworzona z niej kompozycja farmaceutyczna
ZA202008034B (en) Ivosidenib forms and pharmaceutical compositions
GB2564444B (en) Liquid pharmaceutical composition of flecainide
EP3647325A4 (en) PHARMACEUTICAL COMPOSITION OF PCSK-9 ANTIBODIES AND USES THEREOF
ZA202100166B (en) Composition comprising glycyrrhin and cosmetic and pharmaceutical uses thereof
IL276783A (en) The composition and pharmaceutical compound containing it
EP3939998A4 (en) PHARMACEUTICAL COMPOSITION WITH CD40 ANTIBODY AND USE THEREOF
SG11202103374TA (en) Pharmaceutical composition
SG11202103011YA (en) Aromatic compounds and pharmaceutical uses thereof

Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

Free format text: REGISTERED BETWEEN 20240530 AND 20240605