GB2572707A - Particle physical-property measurement device - Google Patents

Particle physical-property measurement device Download PDF

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Publication number
GB2572707A
GB2572707A GB1908169.4A GB201908169A GB2572707A GB 2572707 A GB2572707 A GB 2572707A GB 201908169 A GB201908169 A GB 201908169A GB 2572707 A GB2572707 A GB 2572707A
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United Kingdom
Prior art keywords
cell
measurement
light
measurement cell
property
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GB1908169.4A
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GB201908169D0 (en
Inventor
Mori Tetsuya
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Horiba Ltd
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Horiba Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0042—Investigating dispersion of solids
    • G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The purpose of the present invention is to ensure measurement accuracy while using a measurement cell having a simple structure. Provided is a particle physical-property measurement device 100 that is equipped with a light projecting unit 20 for projecting light onto a measurement sample X in which a particle group is dispersed in a dispersion medium, and a light detection unit 30 for detecting scattered light generated by the projection of the light. The particle physical-property measurement device measures the physical properties of the particles on the basis of the temporal change of the scattered light. The particle physical property measurement device is configured to comprise: a flat measurement cell 10 on which the measurement sample X is placed; a cell holder 20 for holding the measurement cell; and a temperature sensor 5 provided to the measurement cell 10 or the cell holder 20.

Description

SPECIFICATION
Title of Invention
Particle physical-property measurement device
Technical Field [0001]
The present invention relates to a particle physical-property measurement device that measures a physical property of particles, such as a particle size distribution.
Background Art [0002]
As this sort of particle physical-property measurement device, as disclosed in Patent Literature 1, there is one that contains, in a cell, a measurement sample in which a particle group is dispersed in a dispersion medium, as well as detects scattered light produced by radiating light to the cell and measures a particle size distribution. [0003]
In this measurement device, in order to improve measurement accuracy, a cell holder for holding the cell is provided with a temperature sensor to calculate the particle size distribution with the viscosity of the dispersion medium with respect to a detected temperature as an operational parameter.
In addition, to measure particle physical properties related to the movement of particles in the dispersion medium, such as zeta potential and anisotropy, the viscosity of the dispersion medium with respect to the detected temperature is important as well as the above-described particle size distribution measurement.
[0004]
Meanwhile, as the cell for containing a measuring target, the measurement device of Patent Literature 1 uses a square one called a cuvette, and the light is radiated from a side of the cuvette. In such a configuration, in order to make it possible for a measuring target to be exposed to the light radiated from the side even when the amount of the measuring target is small, a cuvette having a thin space for containing the measuring target is required.
[0005]
However, such a cuvette has the problems of being expensive and difficult to clean, and Patent Literature 1 does not consider this at all.
Citation List
Patent Literature [0006]
Patent Literature 1
Japanese Translation of PCT International Application
Publication JP-A2001-83074
Summary of Invention
Technical Problem [0007]
Therefore, the present invention has been made in consideration of such problems, and a main object thereof is to make a measurement cell inexpensive and easy to clean while improving measurement accuracy using a temperature sensor.
Solution to Problem [0008]
That is, a particle physical-property measurement device according to the present invention is a particle physical-property measurement device including: a light radiation part that radiates light to a measurement sample in which a particle group is dispersed in a dispersion medium; and a light detection part that detects scattered light produced by the radiation of the light, and measuring a physical property of particles on the basis of a temporal change in the scattered light, and includes: a flat plate-shaped measurement cell that is mounted with the measurement sample; a cell holder that holds the measurement cell; and a temperature sensor that is provided to the measurement cell or to the cell holder.
[0009]
In the particle physical-property measurement device configured as described above, since the measurement cell or the cell holder is provided with the temperature sensor, the viscosity of the dispersion medium can be calculated on the basis of a detected temperature, and by calculating the physical property of the particles using the viscosity, a measurement error due to the difference between the temperature of the dispersion medium and the detected temperature by the temperature sensor can be suppressed to improve measurement accuracy.
In addition, the measurement cell is a flat plate-shaped one whose structure is simple, and therefore as compared with a square cell called a cuvette, the measurement cell can be made inexpensive and easy to clean.
[0010]
Specific embodiments that perform measurement using the temperature sensor include a configuration further including an arithmetic unit that uses a temperature detected by the temperature sensor to calculate the viscosity of the dispersion medium, and uses the viscosity to calculate a physical property value indicating the physical property of the particles.
[0011]
Meanwhile, particles include ones whose physical property is changed by temperature, ones whose condensation state is changed when temperature is changed, and the like.
Therefore, it is preferable to further include a temperature control mechanism that is provided to the measurement cell or to the cell holder to heat or cool the measurement cell.
In such a configuration, the physical property of the particle can be measured at any temperature, and a temperature-dependent change in the physical property and a temperature-dependent change in the condensation state can be observed.
[0012]
It is preferable that the temperature sensor is provided to the measurement cell; a connecting terminal to be connected with the temperature sensor is provided to the cell holder; and the cell holder holds the measurement cell, and thereby the temperature sensor is connected to the connecting terminal.
In such a configuration, by connecting the temperature sensor to the connecting terminal, the measurement cell is positioned relative to the cell holder. In doing so, when radiating the light from the light radiation part to a predetermined position of the measurement cell, as well as mounting a measuring target in the position, the relative positional relationship between the measuring target and the temperature sensor and the relative positional relationship between the measuring target and the position to which the light is irradiated are unchanged, and a measurement error (systematic error) can be suppressed.
[0013]
Preferably, it is configured that the cell holder is one that holds the measurement cell so that the light is radiated from below, the measurement cell is one having translucency, and the light radiation part is provided below the cell holder to radiate the light to the lower surface of the measurement cell.
In such a configuration, since the light radiation part is provided below the cell holder, a workspace for mounting the measurement cell on the cell holder, and dropping the measurement sample onto the mounted cell holder can be ensured above the cell holder, resulting in good workability.
[0014]
In order to ensure the above-described workspace to be larger, it is preferable that the light detection part is provided below the cell holder, and detects scattered light passing through the lower surface of the measurement cell among the scattered light scattered by the measurement sample.
[0015]
Depending on the arrangement of the light radiation part and the light detection part, reflected light reflected by the measurement cell among the light emitted from the light radiation part is detected by the light detection part, and an error may occur in scattered light intensity to be detected.
Therefore, in order to ensure measurement accuracy, it is preferable that the light detection part is provided in a position not to detect the reflected light reflected by the measurement cell among the light emitted from the light radiation part.
Advantageous Effects of Invention [0016]
According to the present invention configured as described above, the measurement cell can be made inexpensive and easy to clean while improving measurement accuracy using the temperature sensor.
Brief Description of Drawings [0017] [Fig. 1]
Fig. 1 is a schematic diagram illustrating a particle physical-property measurement device in one embodiment of the present invention.
[Fig. 2]
Fig. 2 is a schematic diagram illustrating a measurement cell in the same embodiment.
[Fig. 3]
Fig. 3 is a schematic diagram illustrating a particle physical-property measurement device in another embodiment. [Fig. 4]
Fig. 4 is a schematic diagram illustrating a measurement cell in another embodiment.
[Fig. 5]
Fig. 5 is a schematic diagram illustrating a measurement cell in another embodiment.
[Fig. 6]
Fig. 6 is a schematic diagram illustrating a measurement cell in another embodiment.
[Fig. 7]
Fig. 7 is a schematic diagram illustrating a measurement cell in another embodiment.
[Fig. 8]
Fig. 8 is a schematic diagram illustrating a measurement cell in another embodiment.
[Fig. 9]
Fig. 9 is a schematic diagram illustrating a measurement cell in another embodiment.
[Fig. 10]
Fig. 10 is a schematic diagram illustrating a measurement cell in another embodiment.
[Fig. 11]
Fig. 11 is a schematic diagram illustrating a measurement cell in another embodiment.
Reference Signs List [0018]
100 Particle physical-property measurement device
X Measurement sample
Measurement cell
Cell holder
Light radiation part
Light detection part
Temperature sensor
Thermocouple
Temperature control mechanism
Description of Embodiments [0019]
In the following, one embodiment of the particle physical-property measurement device according to the present invention will be described with reference to drawings.
[0020]
A particle physical-property measurement device 100 according to the present embodiment is, for example, a particle size distribution measurement device that measures a particle size distribution on the basis of the fluctuation of scattered light caused by the Brownian motion of particles, and as illustrated in Fig. 1, includes: a measurement cell 10 mounted with a measurement sample X in which a particle group is dispersed in a dispersion medium such as water; a cell holder 20 installed with the measurement cell 10; a light irradiation part 30 that radiates light to the measurement sample X dropped; a light detection part 40 that detects the scattered light caused by this; and an arithmetic unit C that calculates the particle size distribution on the basis of a temporal change in the scattered light detected by the light detection part 40.
[0021]
As illustrated in Fig. 1, the measurement cell 10 is a flat plate-shaped one, and one to several drops of the measurement sample X are dropped onto one face plate part 11 (hereinafter referred to as an upper surface 11). The term “flat plate-shaped one” here is a concept that, without limitation to a perfect flat plate, also includes one in which a flat plate is provided with a concave part and a convex part, and one having a curved surface.
An area on the upper surface 11 of the measurement cell 10 where the measurement sample X is dropped is not limited; however, here as illustrated in Fig. 2, as a guide, the central part of the upper surface 11 is set as a drop area R where the measurement sample X is dropped. The drop area R here is an area in contact with the measurement sample X on the upper surface 11 or an area set to be slightly larger than the area when dropping a predetermined drop number of or predetermined amount of the measurement sample X onto the upper surface 11. In addition, the dropped measurement sample X is held on the upper surface 11 in a state of being raised by surface tension.
[0022]
The measurement cell 10 in the present embodiment is one that has translucency and allows the light radiated to the other face plate part 12 (hereinafter referred to as a lower surface 12) to transmit through the upper surface 11, and specifically, a transparent substrate of a rectangular shape in a plan view, such as a glass plate. In addition, at an end part or the like of the measurement cell 10, a marker 13 (such as color or a stamp) for discriminating the type of the dropped measurement sample X or discriminating the upper surface 11 or lower surface 12 of the measurement cell 10 is provided. Here, the end part of the measurement cell 10 is a grip part gripped by a user, and on the upper surface 11 side of the grip part, the marker 13 is provided.
[0023]
As illustrated in Fig. 2, the cell holder 20 is one that holds the measurement cell 10, and here has a mount surface 21 on which the measurement cell 10 is mounted from above. The measurement cell 10 mounted on the mount surface 21 is held in a horizontal state.
Specifically, the cell holder 20 is one formed with a step part on which the measurement cell 10 is set, and here the above-described mount surface 21 and a contacted surface 22 contacted by a side surface of the measurement cell 10 mounted on the mount surface 21 form the step part.
[0024]
The mount surface 21 has the same shape (rectangular shape in a plan view) as the lower surface 12 of the measurement cell 10, and in the central part thereof, a light passing hole 21 h through which the light passes is formed. This allows the light passing hole 21 h to be positioned below the central part of the measurement cell 10, i.e., below the drop area R by superposing the entire mount surface 21 and the entire lower surface 12 of the measurement cell 10 on each other. [0025]
As illustrated in Fig. 1, the light radiation part 30 is one that is arranged below the cell holder 20, and by emitting the light toward the above-described light passing hole 21 h, transmits the light through the measurement cell 10 to radiate it to the measurement sample X. Specifically, the light radiation part 30 includes: a laser device 31 as a light source; and a reflective mirror 32 that reflects laser light L emitted from the laser device 31 toward the light passing hole 21 h, and here is arranged so as to obliquely radiate the laser light L to the lower surface 12 of the measurement cell 10 in order to prevent the laser light L reflected by the lower surface 12 of the measurement cell from returning to the laser device 31.
[0026]
As illustrated in Fig. 1, the light detection part 40 is one that is arranged below the cell holder 20 and detects scattered light passing through the light passing hole 21 h among scattered light scattered by the measurement sample X. Specifically, the light detection part 40 includes: a lens 41 as a light receiving part; an optical fiber 42 for transmitting scattered light parallelized by the lens 41; and a light detector 43 that detects the scattered light transmitted through the optical fiber 42.
The light detection part 40 in the present embodiment is provided in a position not to detect the laser light L emitted from the light radiation part 30 and then reflected by the lower surface 12 of the measurement cell 10. Specifically, the lens 41 as a light receiving part is provided in a position displaced from a light path of the reflected light. The lens 41 here is arranged so as to face the lower surface 12 of the measurement cell 10 from obliquely below.
[0027]
Here, the light detector 43 is adapted to calculate an autocorrelation function on the basis of a temporal change in the detected scattered light, and transmit autocorrelation data indicating the autocorrelation function to the below-described arithmetic unit C. [0028]
The arithmetic unit C is physically a general-purpose or dedicated computer including a CPU, memory, input/output interface, and the like, and calculates the particle size distribution by making the CPU and peripheral devices cooperate in accordance with a program stored in a predetermined area of the memory, and thereby acquiring the autocorrelation data calculated by the above-described light detector 43 to perform predetermined arithmetic processing on the autocorrelation function indicated by the autocorrelation data. [0029]
Further, as illustrated in Fig. 1 and Fig. 2, the particle physical-property measurement device 100 of the present embodiment includes a temperature sensor 5 provided to the measurement cell 10. [0030]
Although, as the temperature sensor 5, one using a thermistor or a platinum resistance temperature detector, or the like can be cited, here a thermocouple 51 is used, and the temperature measuring junction of the thermocouple 51 is provided near the above-described drop area R to make it possible to detect the temperature of the drop area R.
The thermocouple 51 here is a linear one provided on the upper surface 11 of the measurement cell 10. More specifically, paired connecting terminals (hereinafter referred to as cell side terminals a1) are provided in an edge part of the upper surface 11 of the measurement cell 10, and the thermocouple 51 is extended from the respective cell side terminals a1 toward the drop area R.
[0031]
In the present embodiment, paired connecting terminals (hereinafter referred to as holder side terminals b1) to be connected with the thermocouple 51 are provided on the above-described cell holder 20 as reference contacts. Specifically, the holder side terminals b1 are provided on the above-described contacted surface 22 of the cell holder 20, and arranged so that the cell side terminals a1 are electrically contacted by superposing the entire lower surface 12 of the measurement cell 10 on the mount surface 21.
This makes it possible to detect the temperature of the drop area R or of the vicinity of it on the basis of a potential difference generated between the holder side terminals b1 by mounting the measurement cell 10 on the mount surface 21 to connect the cell side terminals a1 and the holder side terminals b1.
[0032]
Here, the temperature sensor 5 transmits the detected temperature to the above-described arithmetic unit C, and the arithmetic unit C uses the detected temperature to calculate the viscosity of the dispersion medium, and uses the viscosity and the above-described autocorrelation function to calculate a physical property value (here, the particle size distribution) indicating a physical property of particles.
[0033]
The particle physical-property measurement device 100 of the present embodiment further includes a temperature control mechanism 6 that heats the measurement cell 10. The temperature control mechanism 6 includes: a wire heater 61 as a heating resistor; and a temperature control device 62 that applies voltage to the wire heater 61.
[0034]
The wire heater 61 is a linear one provided on the upper surface 11 of the measurement cell 10. More specifically, paired connecting terminals (hereinafter referred to as second cell side terminals a2) are provide in the edge part of the upper surface 11 of the measurement cell 10, and the wire heater 61 is provided from the respective second cell side terminals a2 so as to surround the drop area R.
In addition, as with the above-described holder side terminals b1, paired connecting terminals (hereinafter referred to as second holder side terminals b2) that are electrically connected with the second cell side terminals a2 by mounting the measurement cell 10 on the mount surface 21 of the cell holder 20 are provided on the contacted surface 22.
[0035]
The temperature control device 62 is physically one including at least an electronic board, here includes a CPU, a memory, and the like besides, and by making the CPU and peripheral devices cooperate in accordance to a program stored in a predetermined area of the memory, acquires the detected temperature detected by the temperature sensor 5 to control the voltage to be applied to the wire heater 61 so that the detected temperature becomes equal to a preset target temperature.
In addition, the temperature control device 62 is provided to the cell holder 20 here; however, the temperature control device 62 may be provided separately from the cell holder 20 or a function as the temperature control device 62 may be provided to the above-described unillustrated arithmetic unit.
[0036]
According to the particle physical-property measurement device 100 according to the present embodiment configured as described above, since the measurement cell 10 is provided with the temperature sensor 5, the viscosity of the dispersion medium can be calculated on the basis of the detected temperature, and using the viscosity, the particle size distribution can be calculated, thus improving measurement accuracy.
In addition since as the measurement cell 10, a flat plate-shaped one whose structure is simple is used, for example, as compared with a square cell called a cuvette, the measurement cell 10 is inexpensive and easy to clean. In particular, a cuvette used when the amount of the measurement sample X is small is expensive and very difficult to clean, and therefore the above-described working effect is more remarkably produced as the amount of the measurement sample X is decreased.
[0037]
Further, since the measurement cell 10 is provided with the wire heater 61 and also the voltage to be applied to the wire heater is controlled by the temperature control device 62, the measurement cell 10 can be regulated to any temperature, and a temperature-dependent change in physical property and a temperature-dependent change in condensation state can be observed.
[0038]
Also, by mutually superposing the lower surface 12 of the measurement cell 10 on the mount surface 21 of the cell holder 20, the cell side terminals a1 of the thermocouple 51 are connected to the holder side terminals b1, and also the second cell side terminals a2 of the wire heater 61 are connected to the second holder side terminals b2, thus making it possible to easily perform the temperature detection and temperature control of the measurement cell 10.
In addition, by connecting the cell side terminals a1 and the second cell side terminals a2 to the holder side terminals b1 and the second holder side terminals b2, the measurement cell 10 is positioned relative to the cell holder 20. In doing so, the drop area R set on the measurement cell 10 and an area to which the laser light L from the light radiation part 30 is radiated can be prevented from being displaced in position, and a measurement error (systematic error) due to such positional displacement can be suppressed.
[0039]
Further, since the light radiation part 30 and the light detection part 40 are provided below the cell holder 20, a workspace for mounting the measurement cell 10 on the cell holder 20 and dropping the measurement sample X onto the mounted cell holder 20 can be ensured above the cell bolder 20, resulting in good workability.
[0040]
In addition, since the lens 41 as a light receiving part is displaced from the light path of the reflected light reflected by the lower surface 12 of the measurement cell 10 among the light emitted from the light radiation part 30, the reflected light can be avoided from being detected by the light detection part 40, and a measurement error due to the reflected light can be suppressed.
[0041]
Further in addition, since the wire heater 61 is provided so as to surround the drop area R, the whole of the drop area R can be uniformly heated.
[0042]
Also, for example, in the case of protein as a measuring target, a change in protein structure such as a protein condensation state can be observed by making the temperature control mechanism 6 change the temperature of the protein.
[0043]
Note that the present invention is not limited to the above-described embodiment.
[0044]
For example, in the above-described embodiment, the temperature sensor 5 is provided on the measurement cell 10; however, as illustrated in Fig. 3, the temperature sensor 5 may be provided on the cell holder 20. In this case, the temperature sensor 5 is preferably in contact with the measurement cell 10 installed on the cell holder 20, and here provided on the mount surface 21.
Also, the same applies to the wire heater 61 constituting the temperature control mechanism 6, and as illustrated in Fig. 3, it may be provided on the cell holder 20. In this case as well, the wire heater 61 is preferably in contact with the measurement cell 10 installed on the cell holder 20, and here provided on the mount surface
21.
[0045]
The temperature control mechanism 6 in the above-described embodiment is one using the linear wire heater 61, but may be one using a sheet-like heater 63 made of, for example, metal foil.
In this case, for example, as illustrated in Fig. 4(a), sheet-like heaters 63 may be provided on side surfaces of the measurement cell 10, or as illustrated in Fig. 4(b), the sheet-like heater may be provided on the upper surface 11 of the measurement cell 10, or although not illustrated, provided on the lower surface 12 of the measurement cell
10. In addition, in the case of providing on the upper surface 11 of the measurement cell 10, in the sheet-like heater 63, a drop hole 62h through which the measurement sample X is dropped is preferably opened.
[0046]
Further, as the arrangement of the thermocouple 51, as illustrated in Fig. 5, the thermocouple 51 may be arranged inside the measurement cell 10 by, in a side surface or the like of the measurement cell 10, forming insertion holes 10h for inserting the thermocouple 51, and inserting the thermocouple 51 from the insertion holes 10h. In addition, the thermocouple 51 is one in which foil-like metal is provided at the tip end of a pair of linear metals.
[0047]
Also, as illustrated in Fig. 6, the measurement cell 10 may be formed with a concave part 14 into which the measurement cell X is dropped. In this case, the measurement cell 10 may be provided with a covering member 15 that is provided so as to cover the concave part 14 to prevent the outflow of the measurement sample X, such as a glass plate.
[0048]
Further, as illustrated in Fig. 7, the measurement cell 10 may be provided with a downflow prevention part 16 that is provided in the outer peripheral part of the measurement cell 10 to prevent the dropped measurement sample X from flowing down.
[0049]
The measurement cell 10 in the above-described embodiment is rectangular-shaped in a plan view; however, the shape of the measurement cell 10 may be appropriately changed to, for example, a circular shape in a plan view as illustrated in Fig. 8, or although not illustrated, a polygonal shape in a plan view, an elliptical shape in a plan view, or the like.
[0050]
Further, as illustrated in Fig. 9, the measurement cell 10 may be one having multiple flat plate-shaped substrates 10a, 10b, 10c stacked in a thickness direction. Specifically, the measurement cell 10 is one such that the measurement sample X is dropped onto the upper surface 11a of the first substrate 10a positioned in the uppermost tier and the thermocouple 51 and the wire heater 61 are provided on the upper surface 11b of the second substrate 10b positioned in the lower tier of the first substrate 10a.
In such a configuration, the thermocouple 51 and the wire heater 61 provided on the upper surface 11b of the second substrate 10b are in contact with the lower surface of the first substrate 10a, and therefore the measurement sample X can be prevented from being attached to the thermocouple 51 and the wire heater 61 while accurately performing the temperature detection and temperature control of the first substrate 10a.
[0051]
Also, the cell holder 20 in the above-described embodiment has the mount surface 21 mounted with the measurement cell 10; however, the cell holder 20 is only required to be one capable of holding the measurement cell 10 in a desired position, and for example, as illustrated in Fig. 9, may be one having a pair of holding members 20a and 20b sandwiching and holding the measurement cell 10 from sides. [0052]
Further, as illustrated in Fig. 10, the cell holder 20 may have sandwiching members 23 that sandwich and hold the measurement cell 10 with the mount surface 21.
Specifically, the sandwiching members 23 are elastic members provided so as to press the measurement cell 10 toward the mount surface 21, and here metallic ones also used as the second holder side connecting terminals b2 connected with the wire heater 61. In addition, the sandwiching members 23 may be used also as the first holder side connecting terminal connected with the thermocouple 51. [0053]
The temperature control mechanism 6 in the above-described embodiment is one that heats the measurement cell, but for example, may be configured to include a Peltier element provided to the measurement cell and cool the measurement cell.
[0054]
In the above-described embodiment, the light radiation part is arranged below the cell holder; however, the arrangement of the light radiation part can be appropriately changed, and for example, it may be arranged above the cell holder to radiate the light to the measurement sample from above, or may be arranged lateral to the cell holder to radiate the light to the measurement sample from a side. In these cases, the measurement cell is not required to have translucency.
[0055]
In the above-described embodiment, the light detection part is arranged below the cell holder; however, the arrangement of the light detection part can be appropriately changed, and for example, it may be arranged above or lateral to the cell holder.
[0056]
In the above-described embodiment, the particle physical-property measurement device is described as the particle size distribution measurement device, but may be a device for measuring zeta potential, a device for measuring the number of particles, a device for measuring the anisotropy of particles, a device for measuring a gel structure (such as a gel mesh distance), a device for measuring inter-particle interaction, or the like.
In addition, as the particle physical-property measurement device for measuring zeta potential, as illustrated in Fig. 11, it is only necessary to include a pair of electrodes 7 provided to the measurement cell 10 and apply electric field to particles. Further, the pair of electrodes 7 may be provided to any of the upper surface 11, lower surface 12, inside of the measurement cell 10, or may be provided to the cell holder (not illustrated).
[0057]
Note that the above-described measurement cell is also one aspect of the present invention.
That is, the measurement cell according to the present invention is a measurement cell including: a light radiation part that radiates light to a measurement sample in which a particle group is dispersed in a dispersion medium; and a light detection part that detects secondary light produced by the radiation of the light, and is used for a particle physical property measurement device that measures a physical property of particles on the basis of a temporal change in the secondary light, and is a flat plate-shaped one mounted with the measurement sample and provided with a temperature sensor.
[0058]
As a device for measuring a physical property of particles on the basis of a temporal change in secondary light, a Raman spectroscopic analyzer that detects Raman light (visible light) as secondary light, a fluorescence spectroscopic analyzer that detects fluorescence as secondary light, and the like can be cited.
In such a device, it is preferable to use, for example, a CCD or the like, as a light detector, and also provide a spectrometer, a filter, and the like between a measurement cell and the light detector. [0059]
Further, the particle physical-property measurement device may be further provided with a scanning mechanism that scans the measurement cell.
In such a configuration, two-dimensional information on the measurement sample can be obtained to grasp the condensation state of the particle group.
[0060]
In addition, the particle physical-property measurement device may be one that detects each of scattered light, Raman light, and fluorescence to measure particle physical properties.
[0061]
Besides, it goes without saying that the present invention is not limited to each of the above-described embodiments, respective partial configurations of them may be combined, and various modifications can be made without departing from the scope thereof. [Industrial Applicability] [0062]
According to the present invention, a particle physical-property measurement device capable of making a measurement cell inexpensive and easy to clean while improving measurement accuracy using a temperature sensor can be provided.

Claims (7)

1. A particle physical-property measurement device comprising: a light radiation part that radiates light to a measurement sample in which a particle group is dispersed in a dispersion medium; and a light detection part that detects scattered light produced by the radiation of the light, and measuring a physical property of particles on a basis of a temporal change in the scattered light, the particle physical-property measurement device comprising:
a flat plate-shaped measurement cell that is mounted with the measurement sample;
a cell holder that holds the measurement cell; and a temperature sensor that is provided to the measurement cell or to the cell holder.
2. The particle physical-property measurement device according to claim 1, further comprising an arithmetic unit that uses a temperature detected by the temperature sensor to calculate a viscosity of the dispersion medium, and uses the viscosity to calculate a physical property value indicating the physical property of the particles.
3. The particle physical-property measurement device according to claim 1, further comprising a temperature control mechanism that is provided to the measurement cell or to the cell holder to heat or cool the measurement cell.
4. The particle physical-property measurement device according to claim 1, wherein the temperature sensor is provided to the measurement cell, a connecting terminal to be connected with the temperature sensor is provided to the cell holder, and the cell holder holds the measurement cell, and thereby the temperature sensor is connected to the connecting terminal.
5. The particle physical-property measurement device according to claim 1, wherein the cell holder is one that holds the measurement cell so that the light is radiated from below, the measurement cell is one having translucency, and the light radiation part is provided below the cell holder to radiate the light to a lower surface of the measurement cell.
6. The particle physical-property measurement device according to claim 5, wherein the light detection part is provided below the cell holder, and detects scattered light passing through the lower surface of the measurement cell among the scattered light scattered by the measurement sample.
7. The particle physical-property measurement device according to claim 1, wherein the light detection part is provided in a position not to detect reflected light reflected by the measurement cell among the light emitted from the light radiation part.
GB1908169.4A 2016-12-14 2017-12-08 Particle physical-property measurement device Withdrawn GB2572707A (en)

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WO2024079473A1 (en) * 2022-10-14 2024-04-18 Malvern Panalytical Limited Thermal compensation

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