GB2553519B - Improvements in or relating to a fluid flow controller for microfluidic devices - Google Patents

Improvements in or relating to a fluid flow controller for microfluidic devices

Info

Publication number
GB2553519B
GB2553519B GB1614904.9A GB201614904A GB2553519B GB 2553519 B GB2553519 B GB 2553519B GB 201614904 A GB201614904 A GB 201614904A GB 2553519 B GB2553519 B GB 2553519B
Authority
GB
United Kingdom
Prior art keywords
relating
fluid flow
flow controller
microfluidic devices
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1614904.9A
Other languages
English (en)
Other versions
GB201614904D0 (en
GB2553519A (en
Inventor
Douglas Anthony
Pertti Jonathan Knowles Tuomas
Mueller Thomas
Lynn Andrew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fluidic Analytics Ltd
Original Assignee
Fluidic Analytics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluidic Analytics Ltd filed Critical Fluidic Analytics Ltd
Priority to GB1614904.9A priority Critical patent/GB2553519B/en
Publication of GB201614904D0 publication Critical patent/GB201614904D0/en
Priority to EP17762186.9A priority patent/EP3507014A1/en
Priority to JP2019511914A priority patent/JP6823712B2/ja
Priority to CN201780053779.5A priority patent/CN109803758B/zh
Priority to PCT/GB2017/052552 priority patent/WO2018042190A1/en
Priority to US16/329,292 priority patent/US11285481B2/en
Publication of GB2553519A publication Critical patent/GB2553519A/en
Application granted granted Critical
Publication of GB2553519B publication Critical patent/GB2553519B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C4/00—Circuit elements characterised by their special functions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00896—Changing inlet or outlet cross-section, e.g. pressure-drop compensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
GB1614904.9A 2016-09-02 2016-09-02 Improvements in or relating to a fluid flow controller for microfluidic devices Expired - Fee Related GB2553519B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB1614904.9A GB2553519B (en) 2016-09-02 2016-09-02 Improvements in or relating to a fluid flow controller for microfluidic devices
PCT/GB2017/052552 WO2018042190A1 (en) 2016-09-02 2017-09-01 Improvements in or relating to a fluid flow controller for microfluidic devices
JP2019511914A JP6823712B2 (ja) 2016-09-02 2017-09-01 マイクロ流体デバイスのための流体流制御器の改良またはそれに関する改良
CN201780053779.5A CN109803758B (zh) 2016-09-02 2017-09-01 用于微流体装置的流体控制器的改进或与之相关的改进
EP17762186.9A EP3507014A1 (en) 2016-09-02 2017-09-01 Improvements in or relating to a fluid flow controller for microfluidic devices
US16/329,292 US11285481B2 (en) 2016-09-02 2017-09-01 Fluid flow controller for microfluidic devices

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1614904.9A GB2553519B (en) 2016-09-02 2016-09-02 Improvements in or relating to a fluid flow controller for microfluidic devices

Publications (3)

Publication Number Publication Date
GB201614904D0 GB201614904D0 (en) 2016-10-19
GB2553519A GB2553519A (en) 2018-03-14
GB2553519B true GB2553519B (en) 2019-12-18

Family

ID=57139825

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1614904.9A Expired - Fee Related GB2553519B (en) 2016-09-02 2016-09-02 Improvements in or relating to a fluid flow controller for microfluidic devices

Country Status (6)

Country Link
US (1) US11285481B2 (enExample)
EP (1) EP3507014A1 (enExample)
JP (1) JP6823712B2 (enExample)
CN (1) CN109803758B (enExample)
GB (1) GB2553519B (enExample)
WO (1) WO2018042190A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201219014D0 (en) 2012-10-23 2012-12-05 Cambridge Entpr Ltd Fluidic device
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB201511651D0 (en) 2015-07-02 2015-08-19 Cambridge Entpr Ltd Viscosity measurements
GB201602946D0 (en) 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
JP6980691B2 (ja) 2016-04-06 2021-12-15 フルイディック・アナリティクス・リミテッド フローバランスの改善またはそれに関連した改善
GB201615452D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to valves for microfluidics devices
GB2553780A (en) 2016-09-12 2018-03-21 Fluidic Analytics Ltd Improvements in or relating to a device and a method for labelling a component
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
US11524292B2 (en) 2019-02-21 2022-12-13 International Business Machines Corporation Programmable hydraulic resistor array for microfluidic chips

Citations (6)

* Cited by examiner, † Cited by third party
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WO2005118138A1 (en) * 2004-06-04 2005-12-15 Crystal Vision Microsystems Llc Device and process for continuous on-chip flow injection analysis
WO2008062708A1 (en) * 2006-11-22 2008-05-29 Konica Minolta Medical & Graphic, Inc. Microchip and microchip inspection system
EP1927401A1 (en) * 2006-11-13 2008-06-04 Konica Minolta Medical & Graphic, Inc. Micro total analysis chip and micro total analysis system
US20100186840A1 (en) * 2008-12-16 2010-07-29 Kartalov Emil P Multi-valve microfluidic devices and methods
WO2011090396A1 (en) * 2010-01-24 2011-07-28 Instytut Chemii Fizycznej Polskiej Akademii Nauk System and method for automated generation and handling of liquid mixtures
WO2017174975A1 (en) * 2016-04-06 2017-10-12 Fluidic Analytics Limited Improvements in or relating to flow balancing

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JPH0240441U (enExample) * 1988-09-10 1990-03-19
US6637463B1 (en) * 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
US6495366B1 (en) 1999-09-03 2002-12-17 Therakos, Inc. Uninterrupted flow pump apparatus and method
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US6880576B2 (en) 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
CA2603969C (en) * 2005-04-08 2014-10-28 Velocys, Inc. Flow control through plural, parallel connecting channels to/from a manifold
JP4556849B2 (ja) * 2005-11-14 2010-10-06 株式会社日立プラントテクノロジー マイクロリアクタシステム
BRPI0915278A2 (pt) * 2008-11-13 2019-09-24 Koninl Philips Electronics Nv sistema microfluídico e método para preencher um canal capilar
EP2490005A1 (en) * 2011-02-18 2012-08-22 Koninklijke Philips Electronics N.V. Microfluidic resistance network and microfluidic device
GB201219014D0 (en) 2012-10-23 2012-12-05 Cambridge Entpr Ltd Fluidic device
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB2528632A (en) 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
JP6815985B2 (ja) * 2014-07-14 2021-01-20 プレジデント アンド フェローズ オブ ハーバード カレッジ 流体システムおよびマイクロ流体システムの改善された性能のためのシステムおよび方法
GB201511651D0 (en) 2015-07-02 2015-08-19 Cambridge Entpr Ltd Viscosity measurements
GB201602946D0 (en) 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
EP3474992A1 (en) 2016-06-27 2019-05-01 Fluidic Analytics Limited Improvements in or relating to sample loading into a microfluidic device
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
GB2553780A (en) 2016-09-12 2018-03-21 Fluidic Analytics Ltd Improvements in or relating to a device and a method for labelling a component
GB201615452D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to valves for microfluidics devices

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118138A1 (en) * 2004-06-04 2005-12-15 Crystal Vision Microsystems Llc Device and process for continuous on-chip flow injection analysis
EP1927401A1 (en) * 2006-11-13 2008-06-04 Konica Minolta Medical & Graphic, Inc. Micro total analysis chip and micro total analysis system
WO2008062708A1 (en) * 2006-11-22 2008-05-29 Konica Minolta Medical & Graphic, Inc. Microchip and microchip inspection system
US20100186840A1 (en) * 2008-12-16 2010-07-29 Kartalov Emil P Multi-valve microfluidic devices and methods
WO2011090396A1 (en) * 2010-01-24 2011-07-28 Instytut Chemii Fizycznej Polskiej Akademii Nauk System and method for automated generation and handling of liquid mixtures
WO2017174975A1 (en) * 2016-04-06 2017-10-12 Fluidic Analytics Limited Improvements in or relating to flow balancing

Also Published As

Publication number Publication date
US20190247855A1 (en) 2019-08-15
JP2019529081A (ja) 2019-10-17
JP6823712B2 (ja) 2021-02-03
US11285481B2 (en) 2022-03-29
CN109803758A (zh) 2019-05-24
GB201614904D0 (en) 2016-10-19
CN109803758B (zh) 2021-10-15
EP3507014A1 (en) 2019-07-10
GB2553519A (en) 2018-03-14
WO2018042190A1 (en) 2018-03-08

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20230902