JP6823712B2 - マイクロ流体デバイスのための流体流制御器の改良またはそれに関する改良 - Google Patents
マイクロ流体デバイスのための流体流制御器の改良またはそれに関する改良 Download PDFInfo
- Publication number
- JP6823712B2 JP6823712B2 JP2019511914A JP2019511914A JP6823712B2 JP 6823712 B2 JP6823712 B2 JP 6823712B2 JP 2019511914 A JP2019511914 A JP 2019511914A JP 2019511914 A JP2019511914 A JP 2019511914A JP 6823712 B2 JP6823712 B2 JP 6823712B2
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- fluid path
- path
- resistance
- low resistance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C4/00—Circuit elements characterised by their special functions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00858—Aspects relating to the size of the reactor
- B01J2219/0086—Dimensions of the flow channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
- B01J2219/00896—Changing inlet or outlet cross-section, e.g. pressure-drop compensation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Mechanical Engineering (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
Description
Claims (10)
- マイクロ流体デバイスへ流体を導入するための流体流制御器(10)であって、
前記制御器は、
前記制御器への入口ポートと前記マイクロ流体デバイスへの接続ポートとの間に設けられる、高抵抗流体経路(12)と、
前記入口ポートと前記接続ポートとの間の低抵抗流体経路(14)であって、前記低抵抗流体経路(14)の抵抗が、前記高抵抗流体経路(12)の抵抗よりも少なくとも10倍小さい、低抵抗流体経路(14)と、
を備え、
前記制御器は、前記低抵抗流体経路(14)を通る、流体流を可能にするように構成される、少なくとも1つの弁(20)を更に備える、
制御器。 - 前記高抵抗流体経路(12)および前記低抵抗流体経路(14)の抵抗が、以下:前記経路の断面積、前記経路の長さおよび前記経路の表面粗さ、のうちの1つまたは複数によって規定される、請求項1に記載の制御器。
- 前記高抵抗流体経路(12)が、1つまたは複数の入口ポートを、1つまたは複数の接続ポートに連結する経路網内の1つの経路である、請求項1または2に記載の制御器。
- 各高抵抗流体経路(12)が、対応する低抵抗流体経路(14)を有する、請求項1または2に記載の制御器。
- 複数の高抵抗流体経路(12)および複数の低抵抗流体経路(14)が配列して設けられる、請求項1から4のいずれか一項に記載の制御器。
- 前記高抵抗流体経路(12)および前記低抵抗流体経路(14)の前記配列を制御するための複数の弁を含むマニホールドを更に備える、請求項5に記載の制御器。
- 前記高抵抗流体経路(12)が、1mbar/μl/hと1000mbar/μl/hとの間の抵抗を有する、請求項1から6のいずれか一項に記載の制御器。
- 前記低抵抗流体経路(14)が、1×10−5mbar/μl/hrの範囲乃至100mbar/μl/hrの範囲の抵抗を有する、請求項1から7のいずれか一項に記載の制御器。
- 前記弁が、前記低抵抗流体経路(14)だけを閉じるように構成される、請求項1から8のいずれか一項に記載の制御器。
- チップへの接点として提供される、請求項1から9のいずれか一項に記載の制御器。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1614904.9A GB2553519B (en) | 2016-09-02 | 2016-09-02 | Improvements in or relating to a fluid flow controller for microfluidic devices |
GB1614904.9 | 2016-09-02 | ||
PCT/GB2017/052552 WO2018042190A1 (en) | 2016-09-02 | 2017-09-01 | Improvements in or relating to a fluid flow controller for microfluidic devices |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019529081A JP2019529081A (ja) | 2019-10-17 |
JP2019529081A5 JP2019529081A5 (ja) | 2020-07-30 |
JP6823712B2 true JP6823712B2 (ja) | 2021-02-03 |
Family
ID=57139825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019511914A Active JP6823712B2 (ja) | 2016-09-02 | 2017-09-01 | マイクロ流体デバイスのための流体流制御器の改良またはそれに関する改良 |
Country Status (6)
Country | Link |
---|---|
US (1) | US11285481B2 (ja) |
EP (1) | EP3507014A1 (ja) |
JP (1) | JP6823712B2 (ja) |
CN (1) | CN109803758B (ja) |
GB (1) | GB2553519B (ja) |
WO (1) | WO2018042190A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201219014D0 (en) | 2012-10-23 | 2012-12-05 | Cambridge Entpr Ltd | Fluidic device |
GB201320146D0 (en) | 2013-11-14 | 2014-01-01 | Cambridge Entpr Ltd | Fluidic separation and detection |
GB201511651D0 (en) | 2015-07-02 | 2015-08-19 | Cambridge Entpr Ltd | Viscosity measurements |
GB201602946D0 (en) | 2016-02-19 | 2016-04-06 | Fluidic Analytics Ltd And Cambridge Entpr Ltd | Improvements in or relating to microfluidic free-flow electrophoresis |
KR102378100B1 (ko) | 2016-04-06 | 2022-03-23 | 플루이딕 애널리틱스 리미티드 | 유동 균형의 향상 또는 이와 관련된 향상 |
GB2553780A (en) | 2016-09-12 | 2018-03-21 | Fluidic Analytics Ltd | Improvements in or relating to a device and a method for labelling a component |
GB201615452D0 (en) | 2016-09-12 | 2016-10-26 | Fluidic Analytics Ltd | Improvements in or relating to valves for microfluidics devices |
GB201615472D0 (en) | 2016-09-12 | 2016-10-26 | Fluidic Analytics Ltd | Improvements in or relating to a reagent cartridge |
US11524292B2 (en) | 2019-02-21 | 2022-12-13 | International Business Machines Corporation | Programmable hydraulic resistor array for microfluidic chips |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53145894U (ja) * | 1977-04-20 | 1978-11-16 | ||
JPH0240441U (ja) * | 1988-09-10 | 1990-03-19 | ||
US6637463B1 (en) * | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
US6495366B1 (en) | 1999-09-03 | 2002-12-17 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
US6919046B2 (en) | 2001-06-07 | 2005-07-19 | Nanostream, Inc. | Microfluidic analytical devices and methods |
US6880576B2 (en) | 2001-06-07 | 2005-04-19 | Nanostream, Inc. | Microfluidic devices for methods development |
WO2005118138A1 (en) * | 2004-06-04 | 2005-12-15 | Crystal Vision Microsystems Llc | Device and process for continuous on-chip flow injection analysis |
US7641865B2 (en) * | 2005-04-08 | 2010-01-05 | Velocys | Flow control through plural, parallel connecting channels to/from a manifold |
JP4556849B2 (ja) * | 2005-11-14 | 2010-10-06 | 株式会社日立プラントテクノロジー | マイクロリアクタシステム |
JP2008122233A (ja) * | 2006-11-13 | 2008-05-29 | Konica Minolta Medical & Graphic Inc | マイクロ総合分析チップおよびマイクロ総合分析システム |
JPWO2008062708A1 (ja) * | 2006-11-22 | 2010-03-04 | コニカミノルタエムジー株式会社 | マイクロチップ及びマイクロチップ検査システム |
BRPI0915278A2 (pt) * | 2008-11-13 | 2019-09-24 | Koninl Philips Electronics Nv | sistema microfluídico e método para preencher um canal capilar |
US8424560B2 (en) * | 2008-12-16 | 2013-04-23 | University Of Southern California | Multi-valve microfluidic devices and methods |
EP2451577A1 (en) * | 2010-01-24 | 2012-05-16 | Instytut Chemii Fizycznej Polskiej Akademii Nauk | System and method for automated generation and handling of liquid mixtures |
EP2490005A1 (en) * | 2011-02-18 | 2012-08-22 | Koninklijke Philips Electronics N.V. | Microfluidic resistance network and microfluidic device |
GB201219014D0 (en) | 2012-10-23 | 2012-12-05 | Cambridge Entpr Ltd | Fluidic device |
GB201320146D0 (en) | 2013-11-14 | 2014-01-01 | Cambridge Entpr Ltd | Fluidic separation and detection |
GB2528632A (en) | 2014-04-30 | 2016-02-03 | Cambridge Entpr Ltd | Fluidic analysis and separation |
EP3169626A4 (en) * | 2014-07-14 | 2018-04-04 | President and Fellows of Harvard College | Systems and methods for improved performance of fluidic and microfluidic systems |
GB201511651D0 (en) | 2015-07-02 | 2015-08-19 | Cambridge Entpr Ltd | Viscosity measurements |
GB201602946D0 (en) | 2016-02-19 | 2016-04-06 | Fluidic Analytics Ltd And Cambridge Entpr Ltd | Improvements in or relating to microfluidic free-flow electrophoresis |
KR102378100B1 (ko) * | 2016-04-06 | 2022-03-23 | 플루이딕 애널리틱스 리미티드 | 유동 균형의 향상 또는 이와 관련된 향상 |
JP2019520981A (ja) | 2016-06-27 | 2019-07-25 | フルイディック・アナリティクス・リミテッド | マイクロ流体デバイスの改良またはマイクロ流体デバイスへの試料充填に関する改良 |
GB201615472D0 (en) | 2016-09-12 | 2016-10-26 | Fluidic Analytics Ltd | Improvements in or relating to a reagent cartridge |
GB201615452D0 (en) | 2016-09-12 | 2016-10-26 | Fluidic Analytics Ltd | Improvements in or relating to valves for microfluidics devices |
GB2553780A (en) | 2016-09-12 | 2018-03-21 | Fluidic Analytics Ltd | Improvements in or relating to a device and a method for labelling a component |
-
2016
- 2016-09-02 GB GB1614904.9A patent/GB2553519B/en not_active Expired - Fee Related
-
2017
- 2017-09-01 JP JP2019511914A patent/JP6823712B2/ja active Active
- 2017-09-01 EP EP17762186.9A patent/EP3507014A1/en active Pending
- 2017-09-01 US US16/329,292 patent/US11285481B2/en active Active
- 2017-09-01 WO PCT/GB2017/052552 patent/WO2018042190A1/en unknown
- 2017-09-01 CN CN201780053779.5A patent/CN109803758B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN109803758B (zh) | 2021-10-15 |
US11285481B2 (en) | 2022-03-29 |
GB2553519B (en) | 2019-12-18 |
GB201614904D0 (en) | 2016-10-19 |
EP3507014A1 (en) | 2019-07-10 |
WO2018042190A1 (en) | 2018-03-08 |
US20190247855A1 (en) | 2019-08-15 |
JP2019529081A (ja) | 2019-10-17 |
CN109803758A (zh) | 2019-05-24 |
GB2553519A (en) | 2018-03-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6823712B2 (ja) | マイクロ流体デバイスのための流体流制御器の改良またはそれに関する改良 | |
US20110146390A1 (en) | Process for Continuous On-Chip Flow Injection Analysis | |
JP6980691B2 (ja) | フローバランスの改善またはそれに関連した改善 | |
US7932098B2 (en) | Microfluidic system utilizing thin-film layers to route fluid | |
US10981166B2 (en) | Manual or electronic pipette driven well plate for nano-liter droplet storage and methods of using same | |
US20040086872A1 (en) | Microfluidic system for analysis of nucleic acids | |
JP2004093553A (ja) | 微小流動路用カスケード式流体力学的集束方法及び装置 | |
WO2002028507A3 (en) | Electronic detection of interaction based on the interruption of flow | |
Taylor et al. | Simulation of microfluidic pumping in a genomic DNA blood-processing cassette | |
Greenwood et al. | Collection of Gaseous and Aerosolized Samples Using Microfluidic Devices With Gas–Liquid Interfaces | |
US7625762B1 (en) | Coaxial tubular sequestering device for micro spheres and cells | |
TWI658274B (zh) | 晶片至晶片流體互連裝置 | |
US20120216403A1 (en) | Loading element | |
WO2017001436A1 (en) | Valve-less mixing method and mixing device | |
TWI486205B (zh) | 微型混合元件及微流體晶片 | |
KR100785029B1 (ko) | 유체 흐름 제어 장치 및 유체 흐름 제어 방법 | |
EP3313559A1 (en) | Valve-less mixing method and mixing device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200616 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200616 |
|
A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20200616 |
|
A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20200624 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20201016 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201030 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201126 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20201225 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210108 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6823712 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |