CN109803758B - 用于微流体装置的流体控制器的改进或与之相关的改进 - Google Patents

用于微流体装置的流体控制器的改进或与之相关的改进 Download PDF

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Publication number
CN109803758B
CN109803758B CN201780053779.5A CN201780053779A CN109803758B CN 109803758 B CN109803758 B CN 109803758B CN 201780053779 A CN201780053779 A CN 201780053779A CN 109803758 B CN109803758 B CN 109803758B
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fluid
path
resistance
fluid path
low resistance
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Expired - Fee Related
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CN201780053779.5A
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Chinese (zh)
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CN109803758A (zh
Inventor
安东尼·道格拉斯
图奥马斯·佩尔蒂·乔纳森·诺尔斯
托马斯·米勒
安德鲁·莱恩
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Fluidic Analytics Ltd
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Fluidic Analytics Ltd
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C4/00—Circuit elements characterised by their special functions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00896—Changing inlet or outlet cross-section, e.g. pressure-drop compensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
CN201780053779.5A 2016-09-02 2017-09-01 用于微流体装置的流体控制器的改进或与之相关的改进 Expired - Fee Related CN109803758B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1614904.9 2016-09-02
GB1614904.9A GB2553519B (en) 2016-09-02 2016-09-02 Improvements in or relating to a fluid flow controller for microfluidic devices
PCT/GB2017/052552 WO2018042190A1 (en) 2016-09-02 2017-09-01 Improvements in or relating to a fluid flow controller for microfluidic devices

Publications (2)

Publication Number Publication Date
CN109803758A CN109803758A (zh) 2019-05-24
CN109803758B true CN109803758B (zh) 2021-10-15

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CN201780053779.5A Expired - Fee Related CN109803758B (zh) 2016-09-02 2017-09-01 用于微流体装置的流体控制器的改进或与之相关的改进

Country Status (6)

Country Link
US (1) US11285481B2 (enExample)
EP (1) EP3507014A1 (enExample)
JP (1) JP6823712B2 (enExample)
CN (1) CN109803758B (enExample)
GB (1) GB2553519B (enExample)
WO (1) WO2018042190A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201219014D0 (en) 2012-10-23 2012-12-05 Cambridge Entpr Ltd Fluidic device
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB201511651D0 (en) 2015-07-02 2015-08-19 Cambridge Entpr Ltd Viscosity measurements
GB201602946D0 (en) 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
EP3439783A1 (en) 2016-04-06 2019-02-13 Fluidic Analytics Limited Improvements in or relating to flow balancing
GB201615452D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to valves for microfluidics devices
GB2553780A (en) 2016-09-12 2018-03-21 Fluidic Analytics Ltd Improvements in or relating to a device and a method for labelling a component
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
US11524292B2 (en) 2019-02-21 2022-12-13 International Business Machines Corporation Programmable hydraulic resistor array for microfluidic chips

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CN101183103A (zh) * 2006-11-13 2008-05-21 柯尼卡美能达医疗印刷器材株式会社 微综合分析芯片及微综合分析系统
CN101218019A (zh) * 2005-04-08 2008-07-09 维罗西股份有限公司 通过多个平行的连接通道流向/来自歧管的流体控制
CN102215967A (zh) * 2008-11-13 2011-10-12 皇家飞利浦电子股份有限公司 微流体系统的入口与毛细管通道的连接
CN103354897A (zh) * 2011-02-18 2013-10-16 皇家飞利浦有限公司 微流体阻力网络和微流体设备

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US6637463B1 (en) * 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
US6495366B1 (en) 1999-09-03 2002-12-17 Therakos, Inc. Uninterrupted flow pump apparatus and method
US6880576B2 (en) 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
EP1755783A1 (en) * 2004-06-04 2007-02-28 Crystal Vision Microsystems LLC Device and process for continuous on-chip flow injection analysis
JP4556849B2 (ja) * 2005-11-14 2010-10-06 株式会社日立プラントテクノロジー マイクロリアクタシステム
JPWO2008062708A1 (ja) * 2006-11-22 2010-03-04 コニカミノルタエムジー株式会社 マイクロチップ及びマイクロチップ検査システム
US8424560B2 (en) * 2008-12-16 2013-04-23 University Of Southern California Multi-valve microfluidic devices and methods
JP2013527022A (ja) * 2010-01-24 2013-06-27 インスチチュート・ケミィ・フィジズネジ・ポルスキージ・アカデミィ・ナウク 液体混合物の自動形成及び操作システムと方法。
GB201219014D0 (en) 2012-10-23 2012-12-05 Cambridge Entpr Ltd Fluidic device
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB2528632A (en) 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
GB2546424A (en) * 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
GB201511651D0 (en) 2015-07-02 2015-08-19 Cambridge Entpr Ltd Viscosity measurements
GB201602946D0 (en) 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
EP3439783A1 (en) * 2016-04-06 2019-02-13 Fluidic Analytics Limited Improvements in or relating to flow balancing
US20190247853A1 (en) 2016-06-27 2019-08-15 Fluidic Analytics Limited Improvements in or relating to sample loading into a microfluidic device
GB2553780A (en) 2016-09-12 2018-03-21 Fluidic Analytics Ltd Improvements in or relating to a device and a method for labelling a component
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
GB201615452D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to valves for microfluidics devices

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN101218019A (zh) * 2005-04-08 2008-07-09 维罗西股份有限公司 通过多个平行的连接通道流向/来自歧管的流体控制
CN101183103A (zh) * 2006-11-13 2008-05-21 柯尼卡美能达医疗印刷器材株式会社 微综合分析芯片及微综合分析系统
CN102215967A (zh) * 2008-11-13 2011-10-12 皇家飞利浦电子股份有限公司 微流体系统的入口与毛细管通道的连接
CN103354897A (zh) * 2011-02-18 2013-10-16 皇家飞利浦有限公司 微流体阻力网络和微流体设备

Also Published As

Publication number Publication date
GB2553519A (en) 2018-03-14
GB2553519B (en) 2019-12-18
JP2019529081A (ja) 2019-10-17
GB201614904D0 (en) 2016-10-19
CN109803758A (zh) 2019-05-24
EP3507014A1 (en) 2019-07-10
JP6823712B2 (ja) 2021-02-03
US20190247855A1 (en) 2019-08-15
WO2018042190A1 (en) 2018-03-08
US11285481B2 (en) 2022-03-29

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