GB2453982B - Chemical process for the preparation of Medetomidine - Google Patents

Chemical process for the preparation of Medetomidine

Info

Publication number
GB2453982B
GB2453982B GB0720891A GB0720891A GB2453982B GB 2453982 B GB2453982 B GB 2453982B GB 0720891 A GB0720891 A GB 0720891A GB 0720891 A GB0720891 A GB 0720891A GB 2453982 B GB2453982 B GB 2453982B
Authority
GB
United Kingdom
Prior art keywords
medetomidine
preparation
chemical process
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0720891A
Other languages
English (en)
Other versions
GB0720891D0 (en
GB2453982A (en
Inventor
Rasik Somaiya
Muhammad Raza
Jonathan Cranke
Kristian Bragg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norbrook Laboratories Ltd
Original Assignee
Norbrook Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norbrook Laboratories Ltd filed Critical Norbrook Laboratories Ltd
Priority to GB0720891A priority Critical patent/GB2453982B/en
Publication of GB0720891D0 publication Critical patent/GB0720891D0/en
Priority to UY31415A priority patent/UY31415A1/es
Priority to ARP080104589A priority patent/AR068952A1/es
Priority to PE2008001820A priority patent/PE20091088A1/es
Priority to CL2008003185A priority patent/CL2008003185A1/es
Priority to PCT/GB2008/003613 priority patent/WO2009053709A1/en
Publication of GB2453982A publication Critical patent/GB2453982A/en
Application granted granted Critical
Publication of GB2453982B publication Critical patent/GB2453982B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
GB0720891A 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine Expired - Fee Related GB2453982B (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB0720891A GB2453982B (en) 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine
UY31415A UY31415A1 (es) 2007-10-24 2008-10-22 Procedimiento para la preparacion de medetomidina
ARP080104589A AR068952A1 (es) 2007-10-24 2008-10-22 Procedimiento para la preparacion de medetomidina
PE2008001820A PE20091088A1 (es) 2007-10-24 2008-10-23 Proceso para la preparacion de medetomidina
CL2008003185A CL2008003185A1 (es) 2007-10-24 2008-10-24 Procedimiento para la preparacion de medetomidina que considera el acoplamiento entre un siliimidazol y un derivado de alcohol bencilico.
PCT/GB2008/003613 WO2009053709A1 (en) 2007-10-24 2008-10-24 Process for the preparation of medetomidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0720891A GB2453982B (en) 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine

Publications (3)

Publication Number Publication Date
GB0720891D0 GB0720891D0 (en) 2007-12-05
GB2453982A GB2453982A (en) 2009-04-29
GB2453982B true GB2453982B (en) 2009-09-16

Family

ID=38829878

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0720891A Expired - Fee Related GB2453982B (en) 2007-10-24 2007-10-24 Chemical process for the preparation of Medetomidine

Country Status (6)

Country Link
AR (1) AR068952A1 (es)
CL (1) CL2008003185A1 (es)
GB (1) GB2453982B (es)
PE (1) PE20091088A1 (es)
UY (1) UY31415A1 (es)
WO (1) WO2009053709A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101921234B (zh) * 2009-06-12 2012-05-30 中国中化股份有限公司 一种制备美托咪啶的方法
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
HUE037591T2 (hu) * 2011-07-22 2018-09-28 Cambrex Karlskoga Ab Új eljárások 4. szénatomon szubsztituált imidazolok elõállítására
US9126915B2 (en) 2012-05-08 2015-09-08 Lonza Ltd. Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
DK2847173T3 (en) * 2012-05-08 2016-04-04 Lonza Ag METHOD OF PRODUCING Medetomidine
CN105218453B (zh) * 2012-06-28 2017-04-12 隆萨有限公司 用氯丙酮制备美托咪定的方法
CN104220408B (zh) 2012-06-28 2016-01-20 隆萨有限公司 用氯丙酮制备2-(2,3-二甲基苯基)-1-丙醛的方法
CN106588777A (zh) * 2015-10-16 2017-04-26 江苏开元医药化工有限公司 一种盐酸右美托咪定的工业化制备方法
WO2023182903A1 (ru) 2022-03-22 2023-09-28 Общество с ограниченной ответственностью "ВИК-здоровье животных" Способ получения медетомидина и его производных
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2101114A (en) * 1981-07-10 1983-01-12 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2101114A (en) * 1981-07-10 1983-01-12 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis, 1991 (11), 1021-2, Kudzma et al. *

Also Published As

Publication number Publication date
AR068952A1 (es) 2009-12-16
GB0720891D0 (en) 2007-12-05
PE20091088A1 (es) 2009-07-20
WO2009053709A1 (en) 2009-04-30
CL2008003185A1 (es) 2009-03-06
UY31415A1 (es) 2009-05-29
GB2453982A (en) 2009-04-29

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