GB2428577A - Free radical scavenging wound powder - Google Patents

Free radical scavenging wound powder Download PDF

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Publication number
GB2428577A
GB2428577A GB0515787A GB0515787A GB2428577A GB 2428577 A GB2428577 A GB 2428577A GB 0515787 A GB0515787 A GB 0515787A GB 0515787 A GB0515787 A GB 0515787A GB 2428577 A GB2428577 A GB 2428577A
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GB
United Kingdom
Prior art keywords
urate
free radical
wound
healing
spheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0515787A
Other versions
GB0515787D0 (en
Inventor
James Bruce Clapp
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Individual
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Individual
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Publication date
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Priority to GB0515787A priority Critical patent/GB2428577A/en
Publication of GB0515787D0 publication Critical patent/GB0515787D0/en
Publication of GB2428577A publication Critical patent/GB2428577A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Uric acid as monovalent urate is a potent endogenous antioxidant protecting against free radical damage in man and other animals. The free radical peroxynitrite is implicated in non-healing chronic wounds. Urate is a most efficient scavenger of peroxynitrite forming a reduced radical capable of regeneration back into urate in the presence of ascorbate or thiols. Uricase a ubiquitous enzyme, although absent in human tissues, converts urate to allantoin the latter having potent angiogenic wound healing properties. Persistent bacteria, common in chronic non-healing wounds, would generate allantoin from topically applied urate. Synthetic urate spheres formed in a cation rich aqueous solution at ambient temperature, are extracted in ethanol and air-dried to the wound powder. These spheres show stability in various physiological media and added to the low solubility of urate, ensures prolonged local tissue activity; also precluding the risk of systemic absorption causing gout, although excessive application may cause local irritation.

Description

The Description.
Title: Free radical seaven2in2 wound powder.
Background:
Uric acid is recognised as a potent natural antioxidant in living tissues (l3ecker 1993).
with a specific role as a free radical scavenger protecting endothelial nitric oxide synthase (eNOS) a major enzyme involved in wound healing (Kuzkaya Ct al 2005).
Uric acid also may be beneficial to ameliorate glucose-induced diabetic deleiioiation (Cheng-Chin Hsu et al 2005). An oxidative breakdown product of uric acid is the angiogenic allantoin the active constituent of Comfrey (Swnphytwn officinale) alias Knit Bone', which since classical times is reported to having beneficial healing properties. Spherulitic uric acid (urate spheres') form in aqueous solution under high cation concentrations (Mc Nabb 1980), these sphere are size modulated (<SOpm) and do not coalesce in alcohol or dry powder form, giving even dispeisal characteristics a major advantage over simple ground samples Urate spheres made by this method show remarkable stability in various physiological environments and are well tolerated in open skin wounds allowing for the possibility of tissue incorporation (unpublished own work 2005).
Essential features: Spherulitic urate as a potent free radical scavenging wound healing powder application for treatment of chronic non-healing ulcerative wounds typical of diabetes mellitus and venous leg ulcers.
Method: Uric acid is converted into spherulitic urate under saturated aqueous conditions using concentrated sodium hydroxide at room temperature. The aqueous phase is replaced by absolute ethanol (98%), preserving these urate spheres; followed by evaporative drying giving a dry powder of urate spheres. This dry powder is used for direct application to open wounds prior surgical closure in order to suppress chronic non- healing the result of excess free radicals.

Claims (3)

  1. CLAIMS.
    I. A topical wound powder composed of dry synthetic urate spheres for the application to open wounds to promote healing.
  2. 2. Synthetic urate spheres claimed in Claim I made by mixing aqueous solutions of saturate uric acid and concentrated sodium hydroxide replacing the aqueous phase with ethanol and drying to a fme powder.
  3. 3. A wound powder claimed in Claim 1 or Claim 2 that in the presence of uricase of bacterial origin generates allantoin a wound-healing agent.
GB0515787A 2005-08-01 2005-08-01 Free radical scavenging wound powder Withdrawn GB2428577A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0515787A GB2428577A (en) 2005-08-01 2005-08-01 Free radical scavenging wound powder

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0515787A GB2428577A (en) 2005-08-01 2005-08-01 Free radical scavenging wound powder

Publications (2)

Publication Number Publication Date
GB0515787D0 GB0515787D0 (en) 2005-09-07
GB2428577A true GB2428577A (en) 2007-02-07

Family

ID=34983865

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0515787A Withdrawn GB2428577A (en) 2005-08-01 2005-08-01 Free radical scavenging wound powder

Country Status (1)

Country Link
GB (1) GB2428577A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262020B1 (en) * 2000-02-15 2001-07-17 Alphamed Pharmaceuticals Corp. Topical wound therapeutic compositions
US20010041684A1 (en) * 2000-02-15 2001-11-15 John Lezdey Topical wound therapeutic compositions
WO2004096367A1 (en) * 2003-04-28 2004-11-11 Ustav Makromolekularni Chemie Akademie Ved Ceske Republiky A wound-cover material containing radical scavengers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262020B1 (en) * 2000-02-15 2001-07-17 Alphamed Pharmaceuticals Corp. Topical wound therapeutic compositions
US20010041684A1 (en) * 2000-02-15 2001-11-15 John Lezdey Topical wound therapeutic compositions
WO2004096367A1 (en) * 2003-04-28 2004-11-11 Ustav Makromolekularni Chemie Akademie Ved Ceske Republiky A wound-cover material containing radical scavengers

Also Published As

Publication number Publication date
GB0515787D0 (en) 2005-09-07

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)