GB2299998B - Compositions for inhibiting thrombogenesis - Google Patents

Compositions for inhibiting thrombogenesis

Info

Publication number
GB2299998B
GB2299998B GB9606881A GB9606881A GB2299998B GB 2299998 B GB2299998 B GB 2299998B GB 9606881 A GB9606881 A GB 9606881A GB 9606881 A GB9606881 A GB 9606881A GB 2299998 B GB2299998 B GB 2299998B
Authority
GB
United Kingdom
Prior art keywords
compositions
clot
thrombin
thrombus
heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9606881A
Other languages
English (en)
Other versions
GB9606881D0 (en
GB2299998A (en
Inventor
Jeffrey I Weitz
Jack Hirsh
Edward Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamilton Civic Hospitals Research Development Inc
Original Assignee
Hamilton Civic Hospitals Research Development Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/540,324 external-priority patent/US5744457A/en
Application filed by Hamilton Civic Hospitals Research Development Inc filed Critical Hamilton Civic Hospitals Research Development Inc
Publication of GB9606881D0 publication Critical patent/GB9606881D0/en
Publication of GB2299998A publication Critical patent/GB2299998A/en
Application granted granted Critical
Publication of GB2299998B publication Critical patent/GB2299998B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB9606881A 1995-03-31 1996-04-01 Compositions for inhibiting thrombogenesis Expired - Fee Related GB2299998B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41233295A 1995-03-31 1995-03-31
US48587295A 1995-06-07 1995-06-07
US08/540,324 US5744457A (en) 1995-03-31 1995-10-06 Compositions and methods for inhibiting thrombogenesis

Publications (3)

Publication Number Publication Date
GB9606881D0 GB9606881D0 (en) 1996-06-05
GB2299998A GB2299998A (en) 1996-10-23
GB2299998B true GB2299998B (en) 1997-03-26

Family

ID=27410936

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9606881A Expired - Fee Related GB2299998B (en) 1995-03-31 1996-04-01 Compositions for inhibiting thrombogenesis

Country Status (4)

Country Link
EP (1) EP0735050B1 (fr)
AT (1) ATE224918T1 (fr)
DE (1) DE69623840D1 (fr)
GB (1) GB2299998B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
WO1998055515A1 (fr) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Heparine de faible poids moleculaire modifiee inhibant les facteurs de coagulation associes au caillot
EA200100965A1 (ru) * 1999-03-11 2002-08-29 Дюпон Фармасьютикалз Компани Синергизм между низкомолекулярным гепарином и ингибиторами агрегации тромбоцитов, обеспечивающий комбинированную терапию для профилактики и лечения различных тромбоэмболических нарушений
US6794412B1 (en) 1999-03-11 2004-09-21 Bristol-Myers Squibb Pharma Company Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin
JP2002538226A (ja) * 1999-03-11 2002-11-12 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害剤およびアスピリン、組織プラスミノーゲンアクチベータ（ＴＰＡ）、ＧＰＩＩｂ／ＩＩＩａ拮抗剤、低分子量ヘパリンまたはヘパリンの組合せ使用による血栓症の治療
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US9351992B2 (en) * 2007-11-02 2016-05-31 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2207811B1 (fr) * 2007-11-02 2017-01-04 Momenta Pharmaceuticals, Inc. Compositions polysaccharidiques non anticoagulantes
CA2795360A1 (fr) 2010-04-16 2011-10-20 Momenta Pharmaceuticals, Inc. Ciblage tissulaire
BR112012031906A2 (pt) 2010-06-17 2016-08-23 Momenta Pharmaceuticals Inc métodos e composições para modular o crescimento de cabelo e pelos.
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2013095215A1 (fr) * 2011-12-19 2013-06-27 Dilaforette Ab Héparines anticoagulantes de faible poids moléculaire
JP6543467B2 (ja) * 2011-12-19 2019-07-10 ディラホア アクチエボラゲット 二糖繰り返し単位を含んでいる非抗凝固グリコサミノグリカンおよびそれらの医療用途
EP3003324A4 (fr) 2013-05-28 2017-01-25 Momenta Pharmaceuticals, Inc. Compositions pharmaceutiques
WO2014193816A1 (fr) * 2013-05-28 2014-12-04 Momenta Phamaceuticals, Inc. Compositions de polysaccaride et procédés correspondants
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014184A2 (fr) * 1979-01-08 1980-08-06 Kabi AB Fragments d'héparine ayant une activité anticoagulante sélective et procédé pour leur préparation
WO1993016112A1 (fr) * 1992-02-07 1993-08-19 Rhone-Poulenc Rorer S.A. Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916219A (en) * 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IE61565B1 (en) * 1988-08-24 1994-11-16 Akzo Nv Heparin fragments and fractions with anti-HIV action
SE9002550D0 (sv) * 1990-08-01 1990-08-01 Kabivitrum Ab Heparinfragment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014184A2 (fr) * 1979-01-08 1980-08-06 Kabi AB Fragments d'héparine ayant une activité anticoagulante sélective et procédé pour leur préparation
WO1993016112A1 (fr) * 1992-02-07 1993-08-19 Rhone-Poulenc Rorer S.A. Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation

Also Published As

Publication number Publication date
GB9606881D0 (en) 1996-06-05
EP0735050B1 (fr) 2002-09-25
EP0735050A3 (fr) 1997-01-22
ATE224918T1 (de) 2002-10-15
EP0735050A2 (fr) 1996-10-02
DE69623840D1 (de) 2002-10-31
GB2299998A (en) 1996-10-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20100401