GB2227089A - An optical biosensor - Google Patents

An optical biosensor Download PDF

Info

Publication number
GB2227089A
GB2227089A GB8900556A GB8900556A GB2227089A GB 2227089 A GB2227089 A GB 2227089A GB 8900556 A GB8900556 A GB 8900556A GB 8900556 A GB8900556 A GB 8900556A GB 2227089 A GB2227089 A GB 2227089A
Authority
GB
United Kingdom
Prior art keywords
optical
dielectric
coating
refractive index
sensitised
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB8900556A
Other languages
English (en)
Other versions
GB8900556D0 (en
Inventor
Rosemary Cush
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Plessey Co Ltd
Original Assignee
Plessey Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plessey Co Ltd filed Critical Plessey Co Ltd
Priority to GB8900556A priority Critical patent/GB2227089A/en
Publication of GB8900556D0 publication Critical patent/GB8900556D0/en
Priority to PCT/GB1989/001461 priority patent/WO1990008318A1/en
Priority to EP90900247A priority patent/EP0404900A1/de
Publication of GB2227089A publication Critical patent/GB2227089A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7789—Cavity or resonator

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
GB8900556A 1989-01-11 1989-01-11 An optical biosensor Withdrawn GB2227089A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB8900556A GB2227089A (en) 1989-01-11 1989-01-11 An optical biosensor
PCT/GB1989/001461 WO1990008318A1 (en) 1989-01-11 1989-12-06 Improvements in or relating to optical biosensors
EP90900247A EP0404900A1 (de) 1989-01-11 1989-12-06 Optische biosensoren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8900556A GB2227089A (en) 1989-01-11 1989-01-11 An optical biosensor

Publications (2)

Publication Number Publication Date
GB8900556D0 GB8900556D0 (en) 1989-03-08
GB2227089A true GB2227089A (en) 1990-07-18

Family

ID=10649882

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8900556A Withdrawn GB2227089A (en) 1989-01-11 1989-01-11 An optical biosensor

Country Status (3)

Country Link
EP (1) EP0404900A1 (de)
GB (1) GB2227089A (de)
WO (1) WO1990008318A1 (de)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2248497A (en) * 1990-09-26 1992-04-08 Marconi Gec Ltd An optical sensor
GB2256477A (en) * 1991-06-07 1992-12-09 Marconi Gec Ltd Optical sensor with dielectric resonant cavity
US6707561B1 (en) 1999-07-05 2004-03-16 Novartis Ag Sensor platform, apparatus incorporating platform, and process using the platform
US6771376B2 (en) 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
DE102004013388A1 (de) * 2004-03-17 2005-10-13 Schott Ag Anordnung zur Fluoreszensverstärkung
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7497992B2 (en) 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
WO2010026269A1 (es) 2008-09-05 2010-03-11 Universidad Politécnica de Madrid Sistema de detección óptica para bio-ensayos de alta sensibilidad sin marcado
US7718440B2 (en) 2000-10-30 2010-05-18 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7875434B2 (en) 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7923239B2 (en) 2000-10-30 2011-04-12 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7935520B2 (en) 2000-10-30 2011-05-03 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
US8514391B2 (en) 1999-11-05 2013-08-20 Board Of Regents, The University Of Texas System Resonant waveguide-grating devices and methods for using same
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US9778267B2 (en) 2007-07-11 2017-10-03 X-Body, Inc. Methods for identifying modulators of ion channels

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
US6320991B1 (en) * 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
FR2793560A1 (fr) * 1999-09-07 2000-11-17 Commissariat Energie Atomique Support d'analyse a microcavites
US6985664B2 (en) * 2003-08-01 2006-01-10 Corning Incorporated Substrate index modification for increasing the sensitivity of grating-coupled waveguides
KR101006793B1 (ko) 2005-08-11 2011-01-10 에스알유 바이오시스템즈, 인코포레이티드 라벨 없는 바인딩 검출 및 형광 증폭과 조합된 격자-기반센서 및 센서를 위한 판독 시스템
US7737392B2 (en) 2006-11-09 2010-06-15 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
JP4497558B1 (ja) * 2009-05-15 2010-07-07 中国電機製造株式会社 入浴設備

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0175585A1 (de) * 1984-09-21 1986-03-26 Ciba Corning Diagnostics Corp. Dielektrische Wellenleitersensoren und ihre Anwendung in Immunoassays
GB2174802A (en) * 1985-04-12 1986-11-12 Plessey Co Plc Optic-waveguide biosensor
EP0246846A2 (de) * 1986-05-20 1987-11-25 AMERSHAM INTERNATIONAL plc Verfahren und Gerät zur Bestimmung einer Spezies in einer Probe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8620193D0 (en) * 1986-08-19 1986-10-01 Emi Plc Thorn Chemical sensor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0175585A1 (de) * 1984-09-21 1986-03-26 Ciba Corning Diagnostics Corp. Dielektrische Wellenleitersensoren und ihre Anwendung in Immunoassays
GB2174802A (en) * 1985-04-12 1986-11-12 Plessey Co Plc Optic-waveguide biosensor
EP0246846A2 (de) * 1986-05-20 1987-11-25 AMERSHAM INTERNATIONAL plc Verfahren und Gerät zur Bestimmung einer Spezies in einer Probe

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Sensors and Actuators 15 [1988] 273- *

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2248497A (en) * 1990-09-26 1992-04-08 Marconi Gec Ltd An optical sensor
US5229833A (en) * 1990-09-26 1993-07-20 Gec-Marconi Limited Optical sensor
GB2248497B (en) * 1990-09-26 1994-05-25 Marconi Gec Ltd An optical sensor
GB2256477A (en) * 1991-06-07 1992-12-09 Marconi Gec Ltd Optical sensor with dielectric resonant cavity
GB2256477B (en) * 1991-06-07 1995-03-08 Marconi Gec Ltd An optical sensor
US6771376B2 (en) 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US7820106B2 (en) 1999-07-05 2010-10-26 Novartis Ag Sensor platform, apparatus incorporating the platform and process using the platform
US6867869B2 (en) 1999-07-05 2005-03-15 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US6870630B2 (en) 1999-07-05 2005-03-22 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the same
US7064844B2 (en) 1999-07-05 2006-06-20 Novartis Ag Sensor platform, apparatus incorporating the platform and process using the platform
US6707561B1 (en) 1999-07-05 2004-03-16 Novartis Ag Sensor platform, apparatus incorporating platform, and process using the platform
US10359573B2 (en) 1999-11-05 2019-07-23 Board Of Regents, The University Of Texas System Resonant waveguide-granting devices and methods for using same
US8514391B2 (en) 1999-11-05 2013-08-20 Board Of Regents, The University Of Texas System Resonant waveguide-grating devices and methods for using same
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US8247240B2 (en) 2000-10-30 2012-08-21 X-Body, Inc. Method and apparatus for biosensor spectral shift detection
US7718440B2 (en) 2000-10-30 2010-05-18 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US8580578B2 (en) 2000-10-30 2013-11-12 X-Body, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic
US7875434B2 (en) 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7923239B2 (en) 2000-10-30 2011-04-12 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7935520B2 (en) 2000-10-30 2011-05-03 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US8101423B2 (en) 2000-10-30 2012-01-24 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7118710B2 (en) 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US8202735B2 (en) 2002-09-09 2012-06-19 X-Body, Inc. Methods for screening cells and antibodies
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US8551716B2 (en) 2002-09-09 2013-10-08 X-Body, Inc. Methods for screening cells and antibodies
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7927789B1 (en) 2002-12-04 2011-04-19 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7497992B2 (en) 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
US7939339B2 (en) 2004-03-17 2011-05-10 Schott Ag Arrangement for fluorescence amplification
DE102004013388A1 (de) * 2004-03-17 2005-10-13 Schott Ag Anordnung zur Fluoreszensverstärkung
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US9778267B2 (en) 2007-07-11 2017-10-03 X-Body, Inc. Methods for identifying modulators of ion channels
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
US8372592B2 (en) 2008-04-09 2013-02-12 X-Body, Inc. High resolution label free analysis of cellular properties
WO2010026269A1 (es) 2008-09-05 2010-03-11 Universidad Politécnica de Madrid Sistema de detección óptica para bio-ensayos de alta sensibilidad sin marcado

Also Published As

Publication number Publication date
GB8900556D0 (en) 1989-03-08
WO1990008318A1 (en) 1990-07-26
EP0404900A1 (de) 1991-01-02

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Legal Events

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)