GB2219502A

GB2219502A - Pharmaceutical composition containing bezoar bovis

Info

Publication number: GB2219502A
Application number: GB8900710A
Authority: GB
Inventors: Yeong Sul Kim
Original assignee: Individual
Current assignee: Individual
Priority date: 1988-05-16
Filing date: 1989-01-13
Publication date: 1989-12-13
Anticipated expiration: 2009-01-13
Also published as: JPH07110811B2; GB8900710D0; JPH01313435A; CN1038585A; GB2219502B; KR890016973A

Abstract

A pharmaceutical liquid composition is prepared by finely cutting or aqueous extraction of a mixture of Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Ampelopsis Radix, Zingiberis Rhizoma, Dioscoreae Rhizoma, Cinnabaris, Realgar, Aurum, and Mel to form a first product; water or alcohol extraction of a finely cut mixture of Bezoar Bovis, Moschus, and Rhinocerotis to form a second product; providing a Gellatin solution; providing a Borneolum solution; mixing the first and second products and the Gelatin and Borneolum solutions and adding water to produce a composition for oral administration to infants, children or critical patients.

Description

PHARMACEUTICAL COMPOSITION CONTAINING BEZOAR BOVIS The present invention relates generally to a novel pharmaceutical liquid composition containing Bezoar Bovis for use in cleaning a patient's chest and, specifically, to a composition for treating patients suffering from stroke, arteriosclerosis, hypertension, tachycardia, dyspnea, anxiety, cardiostenosis, acute and chronic convulsion, automatic nervous system disease, and coma, and to a preparation method for its manufacture. More particularly, the present invention relates to the preparation of oral and parental natural substance liquids of improved physical stability.

The only known prior art of solid composition preparations obtained from natural substances is found in "Annals of Oriental Medicine" by Joon Huh. This publication discloses a solid Bezoar Bovis pill containing 45mg of Bezoar Bovis, 187.5mg of Glycyrrhizae Radix, 93.7mg of Ginseng Radix, 93.7mg of Typhae Pollen, 93.7mg of Massa Medicata Fermentata, 65.6mg of Sojae germinatum Semen, 65.6mg of Cinnamomi Cortex, 65.6mg of Gellatin, 56.2mg of Paeoniae Radix, 55.6mg of Liriopsis tuber, 56.2mg of Scutellariae Radix, 56.2mg Angelicae Gigantis Radix, 56.2mg of Ledebouriellae Radix, 56.2mg of Atractylodis Rhizoma Alba, 46.8mg of Bupleuri Radix, 46.8mg of Platycodi Radix, 46.8mg of Armeniacae Semen, 46.8mg Hoelen, 46.8mg of Cnidii Rhizoma, 37.5mg of Antellopis Cornu, 37.5mg of Moschus, 37.5mg of Borneolum, 28.lmg of Ampelopsis Radix, 28.lmg of Zingiberis Rhizoma, 75mg of Rhinocerotis, 56.2mg of Cinnabaris, 3Omg of Realgar, a piece of Aurum, 2 grains of Zizyphi Fructus, and QS (Quantum Sufficit) of Mel. However, since the Cinnabaris possesses a heavy metal toxicity, the present time, a modified prescription of the solid Bezoar Bovis pill discloses that at least one of the following substances does not include in the solid Bezoar Bovis pill. That is, Ginseng Radix, Sojae germinatum Semen, Cinnamomi Cortex, Angelicae Gigantis Radix, Ampelopsis Radix, Zingiberis Rhizoma, Rhinocerotis, Cinnabaris, Realgar, Aurum, Zizyphi Fructus, and Mel does not include in the modified prescription of the solid Bezoar Bovis pill.For example, a modified prescription of the solid Bezoar Bovis pill does not include Ginseng Radix, Sojae germination Semen, Cinnamomi Cortex, Angelicae Gigantis Radix, Ampelopsis Radix, Zingiberis Rhizoma, Rhinocerotis, Gelatin, Cinnabaris, and Realgar. Another modified prescription of the solid Bezoar Bovis pill does not include Cinnabaris, Realgar, Zizyphi Fructus, and Mel. A further modified prescription of the solid Bezoar Bovis pill does not include Rhinocerotis, Cinnabaris, Aurum, and Zizyphi Fructus. These modified prescription of the solid Bezoar Bovis pill is still used in cleaning a patient's chest. However, such prior art Bezoar Bovis pills suffer from many disadvantages such as, for example, it is not feasible for patients in critical condition to orally and parentally administer these pills nor for infants and children to orally and parentally administer them.Furthermore, these pills do not provide for treatment of the illness of a patient in a fast manner.

Accordingly, it is an object of the present invention to provide a pharmaceutical liquid composition such as gel or sol preparation which is a mixture of natural substances including Bezoar Bovis, Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelical Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, Zingiberis Rhizoma, Rhinocerotis, Cinnabaris, Realgar, Aurum, Zizyphi Fructus, and Mel for easy oral and parenteral administration thereof to critical patients.

Another object of the present invention is to provide a preparation method of pharmaceutical liquid from the above-identified natural substances or the above-identified natural substances which does not include several substances therefrom for providing medication to infants and children.

A further object of the present invention is to provide a preparation method for manufacturing a pharmaceutical liquid composition containing ox Bezoar Bovis for cleaning a patient's chest.

Other objects and further scope of applicability of the present invention will become apparent from the detailed description given hereinafter. It should be understood, however, that the detailed description and specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

The present invention pertains to a pharmaceutical liquid composition prepared by a process which comprises providing a predetermined quantity of natural substances from the genera Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, Zingiberis Rhizoma, Cinnabaris, Realgar, Aurum, Zizyphi Fructus, and Mel; cutting the natural substances into a microparticle size and/or extracting the natural substances with water to form a first extract; providing a predetermined quantity of natural substances from the genera Bezoar Bovis, Moschus, and Rhinocerotis; cutting the natural substances into a microparticle size and extracting the natural substances with ethanol to form a second extract; providing a genus Borneolum solution and a genus Gellatin solution; mixing the first extract with the second extract and the Borneolum and Gellatin solutions to form a mixture; and preparing the mixture with water to produce a pharmaceutical liquid composition for orally administering to patients such as infants, children, critical patients, and the like.

Referring now in detail to the present invention, there is provided a pharmaceutical liquid composition for use in cleaning the chest of the patients, the composition being made from natural substances, namely, the genera Bezoar Bovis, Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, Zingiberis Rhizoma, Rhino Cerotis, Cinnabaris, Realgar, Aurum, Zizyphi Fructus, and Mel.Before the cutting or extracting the natural substances, the genera Bezoar Bovis, Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, Zingiberis Rhizoma, Rhino Cerotis, Cinnabaris, Realgar, Aurun, Zizyphi Fructus, and Mel are mixed together in a predetermined weight ratio.

First of all, 450g of Diosccreae Rhizoma; 320g of Glycyrrhizae Radix; 180g of Cnidii Rhizoma; 160g of Ginseng Radix, Typhae Pollen, and Massa Medicata Fermentata; 130g of Sojae germinatum Semen and Cinnamomi Cortex; 12 0g of Ledebouriellae Radix; llOg of Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, and Atractylodis Rhizoma Alba; loOg of Mel; 90g of Borneolum; 84g of Hoelen; 80g of Bupleuri Radix, Platycodi Radix, and Armeniacae Semen; 65g of Antellopis Cornu; 46g of Ampelopsis Radix and Zingiberis Rhizoma; 50g of Realgar; and 26g of Aurum and Zizyphi Fructus are cut into microparticle size, extracted with 5 times the volume of water as the mixture for about 2 hours, and filtered to form a first extract and then the filtrate is filtered again after 5 times the volume of water as the filtrate is added into the filtrate.

Secondly, 150g of Rhinocerotis; 14g of Bezoar Bovis; and 38g of Moschus are cut into microparticle size to produce a microparticle product. 5 times the volume of ethanol as the microparticle product is added to the microparticle product for about 10 days, filtered, and concentrated. At this time, the ethanol is recovered, condensed, and reintroduced to the filtrate. 150g of sodium alginate and 200g water are added to the condensed solution to form a second extract.

Thirdly, 66g of Gellatin is added to distilled water at an elevated temperature to produce a Gellatin solution.

Fourthly, log of sugar and lKg of solvitol or "Aspartamen are added to water to form a sweetening solution and is added to the above-produced second extract.

Fifthly, 90g of Borneolum and 5g of Menthol are solved in QS of ethanol to form a Burneolum solution.

The above-produced first extract, second extract, Borneolum solution and Gellatin solution are then mixed together with QS water to be 30 liter of the volume of total mixture solution to produce a pharmaceutical liquid composition for orally administering to patients. At this time, if necessary, a preservative, sweetening agent, stabilizer, solvent, emulsifier, colloidifier, aromatic agent, or the like can be added and mixed with the above-resulted liquid composition.

The various species of the genera of natural substances found to be useful for the pharmaceutical composition of the present invention are Bos taurus var domesticus Gmelin of Bezoar Bovis, Glycyrrhiza glabra Linne var grandifera or Glycyrrhiza uratensis of Glycyrrhizae Radix, Panax schinseng Nees of Ginseng Radix, Typhar orientalis presl of Typhae Pollen, Glycine max Merril of Sojae germinatum Semen, Cinnamomum Cassia of Cinnamomi Cortex, Paeonia albiflora pallas var. trlchocarpa of Paeoniae Radix, Liriope platyphylla Wang at Tang of Liriopsis tuber, Scutellaria baicalensis Georgi of Scutellariae Radix, Angelica gigas Nakai of Angelical Gigantis Radix, Ledebouriella seseloides Wolff of Ledebouriellae Radix, Atractylodes japonica Koidzumi of Atractylodis Rhizoma Alba, Bupleurum falcatum Linne of Bupleuri Radix, Platycodon grandiflorum A de Candolle of Platycodi Radix, Prunus armeniaca Linne var. ansu Maximowicz or P. mandshurica Kochne var. glabra Nakai of Armeniacae Semen, Poria cocos Wolf of Hoelen, Cnidium officinale Makino of Cnidii Rhizoma, Gazella subgutturosa Guldenstaedt of Antellopis Cornu, Moschus moschiferus Linne of Moschus, Bryobalanops aromatica Gaertner of Borneolum, Ampelopsis japonica Makino of Ampelopsis Radix, Zingiber officinale Roscoe of Zingiberis Rhizoma Dioscorea japonica Thumberg of Dioscoreae Rhizoma, Rhinocerotus biornis Linne of Rhinocerotis, Cinnabaris, Realgar, Aurum, and Zizyphus vulgaris Lamark of Zizyphi Fructus.

Preservatives useful according to the present invention include p-oxybenzoic propyl ester (propyl-p-ben) p-oxybenzoic methyl ester (methyl-p-ben), sodium phosphoric benzoate, and the like.

Sweetening agents useful in accordance with the present invention include honey, sugar, sorbitol, saccharine, "Aspartame", and the like.

Solvents useful for the present invention include distilled water, ethanol, and the like.

Colloidal agents and emulsifiers which may be used include sodium carboxymethylcellulose, pectin, agar, alganic acid, and the like.

Useful aromatic agents include menthol, cinnamomi cortex, orange perfume, and the like.

The present invention will now be described in more detail in connection with the following examples which should be considered as being exemplary and not limiting the present invention.

Example 1 263g of Dioscoreae Rhizoma; 188g of Glycyrrhizae Radix; 94g of Ginseng Radix, Typhae Pollen, and Massa Medicata Fermentata; 66g of Sojae germinatum Semen and Cinnamomi Cortex; 56g of Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, and Atractylodis Rhizoma Alba; 47g of Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, and Cnidii Rhizoma; 38g of Antellopis Cornu; and 28g of Ampelopsis Radix and Zingiberis Rhizoma are cut into microparticle size by a cutting apparatus. Then 7.5 liters of water are added to approximately 1.5Kg of the natural substance mixture in an extractor. The mixture in the extractor is stirred and condensed. Thereafter, the aqueous mixture is filtered and residues from the first filtration are extracted with water and are again filtered.Both filtrates are condensed for about 2 hours to produce a natural substance extract.

45g of Bezoar Bovis; 38g of Moschus and Borneolum; and 300g of carboxymethylcellulose are ground into microparticle size in a grinder to form a microparticle mixture. Then 200ml of water are added to the microparticle mixture to produce a Bezoar Bovis solution. 1OKg of sugar and 1Kg of sorbitol or 1Kg of Aspartame" are solved with QS of distilled water to make a sweetening solution which is added to the Bezoar Bovis liquid to produce a Bezoar Bovis mixture solution.

QS of distilled water is added to 66g of the genus Gellatin and the aqueous mixture is heated to produce a Gellatin liquid.

38g of Borneolum and 5g of R menthol are added to QS of ethanol to produce a Borneolum solution.

The above-produced products, that is the natural substance extract, the Bezoar Bovis mixture solution, the Gellatin solution, and the Borneolum solution are mixed together with QS of distilled water to a 30 liter volume. Thereafter, the mixture is stirred uniformly to produce a pharmaceutical liquid product for orally and parenterally administering to patients.

The final pharmaceutical liquid product can be prepared as a gel, sol, or a like preparation for easy administration and so as to simplify packaging.

EXAMPLE 2 The pre-extraction procedures in forming the natural substance mixture in Example 1 are repeated. Then 7.5 liters of ethanol are added to the natural substance mixture at a cold temperature and the extract allowed to stand for about 10 days.

The mixture is filtered and QS of distilled water is added to the residues from the first filtration to make again a natural substance extract.

The procedures for making the first and second extracts, and the Bezoar Bovis mixture solution and the Gel latin solution of Example 1 are repeated. The natural substance extract, the Bezoar Bovis mixture solution, and the Gellatin solution are mixed and added to 30 liters of purified water for use as a pharmaceutical, oral liquid.

EXAMPLE 3 The procedures in forming the natural substance mixture as a microparticle size in Example 1 are repeated. The Bezoar Bovis mixture solution, the Gellatin solution and the Borneolum solution in Example 1 are repeated.

The above-produced products, that is, the natural substance, the Bezoar Bovis mixture solution, the Gellatin solution, and the Borneolum solution are mixed together with QS of distilled water to a 30 liter volume. Thereafter, the mixture is stirred uniformly to produce a pharmaceutical liquid product for orally and parenterally administering to patients.

EXAMPLE 4 282g of Dioscoreae Rhizoma; 202g of Glycyrrhizae Radix; 97g of Ginseng Radix; lOOg of Typhae Pollen and Massa Medicata Fermentata; 70g of Sojae germinatum Semen and Cinnamomi Cortex; 60g of Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, and Atractylodis Rhizoma Alba; 50g of Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, and Cnidii Rhizoma; 35g of Antellopis Cornu; 41g of Borneolum; and 30g of Ampelopsis Radix and Zingiberis Rhizoma are cut into microparticle size by a cutting apparatus. Then 7.5 liters of water are added to approximately 1.5Kg of the natural substance mixture in an extractor. The mixture in the extractor is stirred and condensed. Thereafter, the aqueous mixture is filtered and residues from the first filtration are again filtered.Both filtrates are condensed for about 2 hours to produce a natural substance extract.

14g of Bezoar Bovis; 5g of Moschus; 15g of Rhinocertis; and 300g of pectin are ground into microparticle size in a grinder to form a microparticle mixture. Then 200ml of water are added to the microparticle mixture to produce a Bezoar Bovis solution. 1OKg of sugar and 1Kg of sorbitol or "Aspartame" are solved with QS of distilled water to make a sweetening solution which is added to the Bezoar Bovis liquid to produce a Bezoar Bovis mixture solution.

QS of distilled water is added to 70g-of the genus Gellatin and the aqueous mixture is heated to produce a Gellatin liquid.

41g of Borneolum and 5g of Menthol are added to QS of ethanol to produce a Borneolum solution.

EXAMPLE 5 131.25g of Dioscoreae Rhizoma; 93.75g of Glycyrrhizae Radix; 46.875g of Ginseng Radix, Typhae Pollen and Massa Medicata Fermentata; 32.75g of Sojae germinatum Semen and Cinnamomi Cortex; 28g of Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, and Atractylodis Rhizoma Alba; 23.25g of Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, and Cnidii Rhizoma; 18.75g of Antellopis Cornu; 14g of Borneolum, Ampelopsis Radix and Zingiberis Rhizoma; 15g of Realgar; and 12.6g of Zizyphi Fructus are cut into microparticle size by a cutting apparatus.

Then 7.5 liters of water are added to approximately 1.5Kg of the natural substance mixture in an extractor. The mixture in the extractor is stirred and condensed. Thereafter, the aqueous mixture is filtered and residues from the first filtration are again filtered. Both filtrates are condensed for about 2 hours to produce a natural substance extract.

22.5g of Bezoar Bovis; 18.75g of Moschus; 37.5g of Rhinocertis; 28g of Cinnabaris; and lOOg of sodium carboxymethylcellulose are ground into microparticle size in a grinder to form a microparticle mixture. Then 200ml of water are added to the microparticle mixture to produce a Bezoar Bovis solution. 5Kg of sugar and 2Kg of sorbitol or tAspartame' are solved with QS of distilled water to make a sweetening solution which is added to the Bezoar Bovis liquid to produce a Bezoar Bovis mixture solution.

QS of distilled water is added to 32.75g of the genus Gel latin and the aqueous mixture is heated to produce a Gel latin liquid. 18.75g of Borneolum and 15g of Menthol are added to QS of ethanol to produce a Borneolum solution.

The above-produced products, that is the natural substance extract, the Bezoar Bovis mixture solution, the Gellatin solution, and Borneolum solution are mixed together with QS of distilled water to a 30 liter volume. Thereafter, the mixture is stirred uniformly to produce a pharmaceutical liquid product for orally and parenterally administering to patients. The final pharmaceutical liquid product can be prepared as a gel, sol, or a like preparation for easy administration and so as to simplify packaging.

EXAMPLE 6 450g of Dioscoreae Rhizoma; 320g of Glycyrrhizae Radix; 160g of Ginseng Radix, Typhae Pollen and Massa Medicata Fermentata; 130g of Sojae germinatum Semen and Cinnamomi Cortex; llOg of Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, and Atractylodis Rhizoma Alba; 120g of Ledebouriellae Radix; 80g of Bupleuri Radix, Platycodi Radix, Armeniacae Semen; 84g of Hoelen; 180g of Cnidii Rhizoma; 65g of Antellopis Cornu; 90g of Borneolum; 46g of Ampelopsis Radix and Zingiberis Rhizoma; 23g of Cinnabaris; 50g of Realgar; 26g of Aurum, and lOOg of Mel are cut into microparticle size by a cutting apparatus. Then 7.5 liters of water are added to approximately 1.5Kg of the natural substance mixture in an extractor. The mixture in the extractor is stirred and condensed. Thereafter, the aqueous mixture is filtered and residues from the first filtration are again filtered. Both filtrates are condensed for about 2 hours to produce a natural substance extract 14g of Bezoar Bovis; 38g of Moschus; and 150g of Rhinocerotis are ground into microparticle size in a grinder to form a microparticle mixture. Then 5 times of the volume of ethanol as the mixture are added to the microparticle mixture to produce a Bezoar Bovis solution. 1OKg of sugar and 1Kg of sorbitol or "Aspartame" are solved with QS of distilled water to make a sweetening solution which is added to the Bezoar Bovis liquid to produce a Bezoar Bovis mixture solution.

90g of Borneolum and 5g of Z -menthol are added to QS of ethanol to produce a Borneolum solution.

EXPERIMENT 1 The present Experiment 1 is the data resulting from experimentation of the pharmaceutical liquid according to the present invention. A 30ml sample prepared from Example 1 is used in the following tests for determining the respective amounts of (a) active bilirubin (Table 1) at a temperature of 300C and 60 C, (b) active bilirubin in direct sunlight and in a room wherein the sun rays are scattered (Table 2), and active bilirubin after a long period of storage (Table 3) as follows: Table 1

Condition 30 C 60 C Lot No. Result PH Density vlscoslty Content Resm;t PH Dcnslty vlscoslly Content SU- Begin- Suita- 4.819 1.130 20.62 189.6 Sulta- 4.819 1.103 20.61 189.6 B3001 ning bility b@@@@γ; 2 (Months) " 4.818 1.130 20.61 100.1 " 4.819 1.131 20.54 189.6 4 (Months) " 4.817 1.131 20.64 188.6 " 4.818 1.132 20.55 188.4 6 (Months) " 4.816 1.130 20.65 180.2 " 4.810 1.131 20.57 107.0 SU- Begin- " 4.821 1.132 20.52 189.8 " 4.821 1.130 20.52 189.8 B3001 ning 2 (Months) " 4.820 1.130 20.55 189.3 " 4.022 1.120 20.55 190.1 4 (Months) " 4.818 1.130 20.56 189.2 " 4.186 1.131 20.35 188.2 6 (Months) " 4.819 1.131 20.58 187.4 " 4.010 1.131 20.57 188.3 SU- Begin- " 4.817 1.131 20.63 190.2 " 4.017 1.131 20.63 190.2 B3001 ning 2 (Months) " 4.819 1.132 20.63 190.2 " 4.017 1.130 20.52 188.4 4 (Months) " 4.817 1.131 20.65 190.0 " 4.010 1.132 20.56 107.9 6 (Months) " 4.816 1.132 20.66 187.8 " 4.816 1.132 20.58 106.9 Table 2

Lot No. SU-83001 SU-83002 SU-83003 con-dition Resi;t pH Density Viscosity Content Result pH Density Visoosity Content Result PH Density Visoosity Content Begin- Suita- Suita- Suita Di@ect ning bility 4.819 1.130 20.62 189.6 Bility 4.821 1.130 20.52 189.8 bility 4.817 1.131 20.63 190.2 R@y 1 Day " 4.821 1.130 20.63 188.2 " 4.818 1.132 20.49 190.4 " 4.821 1.131 20.55 190.1 2 Days " 4.817 1.131 20.61 188.9 " 4.820 1.131 20.52 188.4 " 4.818 1.132 20.64 189.1 3 Days " 4.818 1.131 20.64 188.2 " 4.816 1.132 20.54 185.8 " 4.817 1.132 20.64 187.7 Begin- " 4.819 1.130 20.62 189.5 " 4.821 1.130 20.52 189.8 " 4.817 1.131 20.63 190.2 ning 5 Days " 4.816 1.130 20.63 188.6 " 4.820 1.132 20.51 188.6 " 4.820 1.132 20.61 188.9 Scatt- 10Days " 4.819 1.131 20.64 189.6 " 4.818 1.131 20.53 189.2 " 4.817 1.132 20.63 189.3 ering 20Days " 4.822 1.130 20.62 189.6 " 4.817 1.133 20.54 187.7 " 4.818 1.132 20.65 188.4 Ray 30Days " 4.817 1.131 20.63 187.2 " 4.819 1.132 20.57 187.3 " 4.816 1.133 20.64 187.8 Table 3

Lot No. SU-38001 SU-83002 SU-83003 con-dition Resi;t pH Density Viscosity Content Result pH Density Visoosity Content Result PH Density Visoosity Content Begin- Suita- Suita- Suitalong ning bility 4.819 1.130 20.62 189.6 Bility 4.821 1.130 20.51 189.8 bility 4.818 1.131 20.63 190.2 periou 3 (Monghs) " 4.819 1.131 20.63 189.9 " 4.820 1.131 20.52 189.7 " 4.818 1.132 20.62 190.2 6 (Monghs) " 4.818 1.129 20.62 188.4 " 4.811 1.132 20.56 190.2 " 4.821 1.131 20.61 188.9 9 (Monghs) " 4.821 1.131 20.65 190.1 " 4.818 1.129 20.55 188.6 " 4.819 1.130 20.64 186.5 12(Monghs) " 4.818 1.129 20.65 188.5 " 4.816 1.131 20.54 187.7 " 4.818 1.132 20.64 186.5 18(Monghs) " 4.817 1.133 20.64 187.7 " 4.817 1.132 20.54 186.9 " 4.819 1.133 20.56 187.4 24(Monghs) " 4.818 1.131 20.65 186.0 " 4.816 1.131 20.57 185.0 " 4.816 1.132 20.67 185.8 EXPERIMENT 2 1.Procedure This method was designed to evaluate activity based on the oral administration of the pharmaceutical liquid from the Example 1 to animals. The animals used in this test were male and female Sprague Dawley rats who were 7-8 weeks old and weighted 220 + 20g, and male and female Day mice who were 6-7 weeks old and weighed 20 + 2.0g and 18 + 2.0g, respectively.

Before performing this test, the animals were fed solid feed stuffs at a temperature of 24 + 20C and a moisture of 65 + 5%.

7 days prior to test initiation, the pharmaceutical liquid of the present invention was orally administrated to the animals.

A group has 10 animals.

2. Results The results obtained from the toxic activity test of the pharmaceutical liquid of the present invention are shown in Tables 4 (Rats) and 5 (Mice) as follows: Sex Dosdye (ml/kg) 1(Day) 2(Days) 3(days) 4(Day) 5(Days) 6(Days) 7(Days) Fotal@ ID50 Male 15 0/10 0/10 30 " 45 " 60 " 75 " 1/10 1/10 Female 15 0/10 0/10 10 30 " " 45 " " 60 " " 75 " " " Table 5 Sex Dosdye (ml/kg) 1(Day) 2(Days) 3(days) 4(Day) 5(Days) 6(Days) 7(Days) Fotal@ ID50 Male 70 0/10 2/10 2/10 20 80 " 2/10 3/10 30 90 " 1/10 2/10 5/10 50 100 " 3/10 5/10 7/10 8/10 80 110 " 2/10 4/10 5/10 7/10 10/10 10/10 100 109.6 Female 70 0/10 0 80 " 1/10 2/10 2/10 20 90 " 2/10 4/10 - 4/10 40 100 " 2/10 4/10 7/10 8/10 8/10 80 110 " 3/10 5/10 8/10 9/10 10/10 100 109.6 In the Table 5, the mice that were treated with a lloml/kg dosage were killed. However, the mice treated with LD50 at 109.6ml/kg of average dosage lived.

Accordingly, the results from Table 4 and 5 indicate suitable toxic activity with the pharmaceutical liquid of the present invention.

Claims

CLAIMS:

1. A process for preparing a pharmaceutical liquid composition which comprises of the steps of: (a) providing a predetermined quantity of first natural substances of the genera Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, Zingiberis Rhizoma, Cinnabaris, Realgar, Aurum, and Mel and cutting said first natural substances into microparticle size and/or extracting said natural substances with a solvent to produce first product;; (b) providing a predetermined quantity of second natural substances from the genera Bezoar Bovis, Moschus, and Rhinocerotis and cutting said second natural substances into microparticle size and extracting said microparticle product with alcohol to form a second product; (c) providing a predetermined quantity of Borneolum to which water is added to produce a Borneolum solution; (d) providing a predetermined quantity of Gellatin to which water is added to produce a Gellatin solution; and (e) uniformly mixing said first product of step (a), said second product of step (b), said Borneolum solution of step (c), and said Gellatin solution of step (d) with water to form a pharmaceutical liquid composition.

2. A process according to claim 1, wherein the Bezoar Bovis, Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, Zingiberis Rhizoma, Cinnabaris, Realgar, Aurum, and Mel are present in an amount of about 14 parts, about 450 parts, about 320 parts, about 160 parts, about 100 parts, about 100 parts, about 130 parts, about 130 parts, about 66 parts, about 110 parts, about 110 parts, about 110 parts, about 110 parts, about 120 parts, about 110 parts, about 80 parts, about 80 parts, about 80 parts, about 84 parts, about 180 parts, about 65 parts, about 18.75 parts, about 180 parts, about 46 parts, about 46 parts and about 23 parts, about 50 parts, about 26 parts, about 100 parts, by weight, respectively.

3. A process according to claim 1 or 2, wherein an aromatic agent, sweetening agent, emulsifier colloidal agent suspension agent, and or preservative are further added to the pharmaceutical liquid composition.

4. A process according to claim 3, wherein the sweetening agent is "Aspartame".

5. A process according to any one of the preceding claims, wherein the alcohol of the step (b) includes ethanol and menthol.

6. A process according to any one of the preceding claims, wherein the solvent is water.

7. A process according to claim 1, substantially as described in any one of the foregoing Examples.

8. A pharmaceutical composition whenever prepared by a process as claimed in any one of the preceding claims.

9 A pharmaceutical liquid composition comprising natural substances of the genera Bezoar Bovis, Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizona Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, and Zingiberis Rhizoma, Cinnabaris, Realgar, Aurum, and Mel.

10. A pharmaceutical composition according to claim 9, wherein the Bezoar Bovis is Bos taurus var. domesticus Gmelin.

11. A pharmaceutical composition according to Claim 9 or 10, wherein the Bezoar Bovis is present in an amount of 14 parts by weight, Dioscoreae Rhizoma is present in an amount of 450 parts, Glycyrrhizae Radix is present in an amount of 320 parts, Ginseng Radix is present in an amount of 160 parts, Typhae Pollen is present in an amount of 160 parts, Massa Medicata Fermentata is present in an amount of 160 parts, Sojae germinatum Semen is present in an amount of 130 parts, Cinnamomi Cortex is present in an amount of 130 parts, Gellatin is present in an amount of 66 parts, Paeoniae Radix is present in an amount of 110 parts, Liriopsis tuber is present in an amount of 110 parts, Scutellariae Radix is present in an amount of 110 parts, Angelicae Gigantis Radix is present in an amount of 110 parts, Ledebouriellae Radix is present in an amount of 120 parts, Atractylodis Rhizoma Alba is present in an amount of 110 parts, Bupleuri Radix is present in an amount of 80 parts, Platycodi Radix is present in an amount of 80 parts, Armeniacae Semen is present in an amount of 80 parts, Hoelen is present in an amount of 84 parts, Cnidii Rhizoma is present in an amount of 180 parts, Antellopis Cornu is present in an amount of 65 parts, Moschus is present in an amount of 38 parts, Borneolum is present in an amount of 90 parts, Ampelopsis Radix is present is present in an amount of 46 parts, Zingiberis Rhizoma is present in an amount of 46 parts, Realgar is present in an amount of 50 parts, Aurum is present in an amount of 26 parts, and Zizyphi Fructus is present in an amount of 26 parts, by weight.

12. A pharmaceutical composition according to claim 9, 10 or 11, further comprising an aromatic agent, sweetening agent, emulsifier, colloidal agent, suspension agent, and/or preservative.

13. A pharmaceutical composition according to claim 9, substantially as described in any one of the foregoing Examples.

14. A process for preparing a pharmaceutical liquid composition which comprises of the steps df: (a) providing a predetermined quantity of first natural substances of the genera Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gel latin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, and Zingiberis Rhizoma are present in an amount of about 45 parts, about 263 parts, about 188 parts, about 94 parts, about 94 parts, about 94 parts, about 66 parts, about 66 parts, about 66 parts, about 56 parts, about 56 parts, about 56 parts, about 56 parts, about 56 parts, about 56 parts, about 47 parts, about 47 parts, about 47 parts, about 47 parts, about 47 parts, about 38 parts, about 38 parts, about 38 parts, about 28 parts, and about 28 parts, by weight, respectively.

16. A process according to claim 14, or 15, wherein an aromatic agent, sweetening agent, emulsifier colloidal agent, suspension agent, and or preservative are further added to the pharmaceutical liquid composition.

17. A process according to claim 14, 15 or 16, wherein the solvent is water.

18. A process according to any one of claims 14 to 17, wherein the sweetening agent is "Aspartame".

19. A pharmaceutical composition whenever prepared by a process as claimed in any one of claims 14 to 18.

20. A pharmaceutical liquid composition comprising natural substances of the genera Bezoar Bovis, Dioscoreae Rhizoma, Glycyrrhizae Radix, Ginseng Radix, Typhae Pollen, Massa Medicata Fermentata, Sojae germinatum Semen, Cinnamomi Cortex, Gellatin, Paeoniae Radix, Liriopsis tuber, Scutellariae Radix, Angelicae Gigantis Radix, Ledebouriellae Radix, Atractylodis Rhizoma Alba, Bupleuri Radix, Platycodi Radix, Armeniacae Semen, Hoelen, Cnidii Rhizoma, Antellopis Cornu, Moschus, Borneolum, Ampelopsis Radix, and Zingiberis Rhizoma.

21. A pharmaceutical composition according to claim 20, wherein the Bezoar Bovis is Bos taurus var. domesticus Gmelin.

22. A pharmaceutical composition according to claim 20 or 21, wherein the Bezoar Bovis is present in an amount of 45 parts by weight, Dioscoreae Rhizoma is present in an amount of 263 parts, Glycyrrhizae Radix is present in an amount of 188 parts, Ginseng Radix is present in an amount of 94 parts, Typhae Pollen is present in an amount of 94 parts, Massa Medicata Fermentata is present in an amount of 94 parts, Sojae germinatum Semen is present in an amount of 66 parts, Cinnamomi Cortex is present in an amount of 66 parts, Gellatin is present in an amount of 66 parts, Paeoniae Radix is present in an amount of 56 parts, Liriopsis tuber is present in an amount of 56 parts, Scutellariae Radix is present in an amount of 56 parts, Angelicae Gigantis Radix is present in an amount of 56 parts, Ledebouriellae Radix is present in an amount of 56 parts, Atractylodis Rhizoma Alba is present in an amount of 56 parts, Bupleuri Radix is present in an amount of 47 parts, Platycodi Radix is present in an amount of 47 parts, Armeniacae Semen is present in an amount of 47 parts, Hoelen is present in an amount of 47 parts, Cnidii Rhizoma is present in an amount of 47 parts, Antellopis Cornu is present in an amount of 38 parts, Moschus is present in an amount of 38 parts, Borneolum is present in an amount of 38 parts, Ampelopsis Radix is present is present in an amount of 28 parts, and Zingiberis Rhizoma is present in an amount of 28 parts, by weight.

23. A process according to claim 14, substantially as hereinbefore described.

24. A pharmaceutical composition according to claim 20, substantially as hereinbefore described.