GB2170806B - 1-(3 mercapto-2-methylpropionyl)-l-proline, precursors thereof and processes for their preparation - Google Patents

1-(3 mercapto-2-methylpropionyl)-l-proline, precursors thereof and processes for their preparation

Info

Publication number
GB2170806B
GB2170806B GB08602782A GB8602782A GB2170806B GB 2170806 B GB2170806 B GB 2170806B GB 08602782 A GB08602782 A GB 08602782A GB 8602782 A GB8602782 A GB 8602782A GB 2170806 B GB2170806 B GB 2170806B
Authority
GB
United Kingdom
Prior art keywords
methylpropionyl
proline
mercapto
precursors
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08602782A
Other languages
English (en)
Other versions
GB2170806A (en
GB8602782D0 (en
Inventor
Don Ki Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boryung Pharmaceutical Co Ltd
Original Assignee
Boryung Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boryung Pharmaceutical Co Ltd filed Critical Boryung Pharmaceutical Co Ltd
Publication of GB8602782D0 publication Critical patent/GB8602782D0/en
Publication of GB2170806A publication Critical patent/GB2170806A/en
Application granted granted Critical
Publication of GB2170806B publication Critical patent/GB2170806B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GB08602782A 1985-02-11 1986-02-05 1-(3 mercapto-2-methylpropionyl)-l-proline, precursors thereof and processes for their preparation Expired GB2170806B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019850000850A KR870001569B1 (ko) 1985-02-11 1985-02-11 피롤리딘 유도체의 제조방법

Publications (3)

Publication Number Publication Date
GB8602782D0 GB8602782D0 (en) 1986-03-12
GB2170806A GB2170806A (en) 1986-08-13
GB2170806B true GB2170806B (en) 1988-08-03

Family

ID=19239706

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08602782A Expired GB2170806B (en) 1985-02-11 1986-02-05 1-(3 mercapto-2-methylpropionyl)-l-proline, precursors thereof and processes for their preparation

Country Status (6)

Country Link
JP (1) JPS61183263A (enrdf_load_stackoverflow)
KR (1) KR870001569B1 (enrdf_load_stackoverflow)
DE (1) DE3538747A1 (enrdf_load_stackoverflow)
ES (1) ES8606269A1 (enrdf_load_stackoverflow)
FR (1) FR2577222B1 (enrdf_load_stackoverflow)
GB (1) GB2170806B (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
EP0432204A4 (en) * 1988-08-26 1992-08-12 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
US5237073A (en) * 1988-08-26 1993-08-17 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
KR940005014B1 (ko) * 1991-11-07 1994-06-09 보령제약 주식회사 피롤리딘카르복실산 유도체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4192945A (en) * 1978-12-07 1980-03-11 E. R. Squibb & Sons, Inc. Process for preparing proline and homoproline derivatives
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
JPS58124764A (ja) * 1982-01-20 1983-07-25 Kanegafuchi Chem Ind Co Ltd 光学活性チオ−ル化合物の製造法

Also Published As

Publication number Publication date
KR870001569B1 (ko) 1987-09-04
ES548744A0 (es) 1986-04-01
GB2170806A (en) 1986-08-13
FR2577222A1 (fr) 1986-08-14
GB8602782D0 (en) 1986-03-12
ES8606269A1 (es) 1986-04-01
JPS61183263A (ja) 1986-08-15
DE3538747C2 (enrdf_load_stackoverflow) 1988-08-18
KR860006441A (ko) 1986-09-11
DE3538747A1 (de) 1986-08-14
FR2577222B1 (fr) 1987-12-24

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19990205