GB2170713A - Medicated wound dressing - Google Patents
Medicated wound dressing Download PDFInfo
- Publication number
- GB2170713A GB2170713A GB08503654A GB8503654A GB2170713A GB 2170713 A GB2170713 A GB 2170713A GB 08503654 A GB08503654 A GB 08503654A GB 8503654 A GB8503654 A GB 8503654A GB 2170713 A GB2170713 A GB 2170713A
- Authority
- GB
- United Kingdom
- Prior art keywords
- skin
- skin substitute
- substitute
- polyurethane elastomer
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F15/00—Auxiliary appliances for wound dressings; Dispensing containers for dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
- A61F13/534—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00119—Wound bandages elastic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00157—Wound bandages for burns or skin transplants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00246—Wound bandages in a special way pervious to air or vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00519—Plasters use for treating burn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
- A61F2013/530802—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium characterized by the foam or sponge other than superabsorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
- A61F13/534—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad
- A61F2013/53445—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad from several sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Materials Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
A dressing to be applied to extensive wound areas for a period of not less than 24 to 48 hours prior to attempting a skin graft is a two layer sheet material comprising a lower layer of porous foam material having an open pore volume of 70-90% and an upper layer of a microporous synthetic plastics material formed of a polyurethane elastomer of M.wt. at least 15000. The entire sheet material is impregnated with an 0.01 to 15% by weight solution of an antiseptic agent.
Description
SPECIFICATION
Human Skin Substitute for Temporary Use
This invention relates to a skin substitute for temporarily covering extensive wound areas such as may be caused by burning, in particular.
It is common practice in the treatment of areas of the body which have been subject to extensive burns to cover the open wound with gauze bandages impregnated with silver nitrate, ointments and other materials. These bandages have to be replaced often because they do not offer a barrier against pathogenic microorganisms. Such bandages thus do not protect the wound against secondary infections and complications occur very often. Hence, the mortality rate with severe burns cases is high. In any case, this treatment does not resolve the main problem of achieving the quick recovery of the skin integrity of the patient. The recovery of skin integrity is usually attempted by skin transplantation which is unsuccessful in most cases in which such gauze bandages have been applied previously.
An alternative to the aforesaid bandaging technique in the treatment of extensive wound areas is the application of a temporary skin substitute in the form of a two layer cover, the lower layer of which is formed of a porous plastics material and the upper layer being formed of a microporous synthetic plastics material. Such a cover is applied directly to the wound area and generally needs to be replaced every two to four hours.
The disadvantage of such a two layer plastics cover is that the very frequent replacement of the dressing which is required is a source of traumatisation of the wound. In addition, the lower microporous layer absorbs the exudates but does not possess antiseptic properties. This makes it a source of secondary infections. Finally, the untimely replacement of such a skin cover can give rise to a considerable amount of bleeding which will obviously have an unfavourable influence on the treatment of the wound.
According to the present invention, there is provided a temporary substitute for human skin, which skin substitute comprises a lower layer for emplacement in contact with a wound and which is formed of a porous foam plastics material having an open pore volume of 70 to 90%, and an upper layer of a microporous synthetic plastics material formed of a polyurethane elastomer having a molecular weight of at least 15,000, the entire skin substitute being impregnated with a 0.01 to 15% by weight solution of an antiseptic agent.
With the skin substitute of this invention, which is intended as far as possible to simulate human skin, the lower layer of porous elastic foam plastics material containing 70 to 90% by volume of open pores is preferably a foam with ether or ester linkages. The upper microporous layer preferably has a thickness of 0.1 to 0.5 mm, is highly elastic and is a polyurethane elastomer with a molecular weight of at least 15,000, generally 15,000 to 20,000. The polyurethane elastomer layer is generally obtained from a solution of a polyurethane in one or more organic solvents selected preferably from dimethylformamide, methylethylketone, toluene and cellulose acetobutyrate.The temporary skin substitute incorporates an impregnating solution of an antiseptic substance which is preferably a quaternary ammonium compound, more preferably cetylpyridinium bromide.
The present invention provides a temporary substitute for human skin covering to be used in the treatment of extensive wound areas. The skin substitute must be replaced at intervals which will not, however, be less than 24 to 48 hours. The skin substitute will not generally be a source of secondary infections and contributes effectively to successful transplantation to the affected area of proper skin. The skin substitute is able to absorb exudates and necrotic tissue.
More particularly, it has been found that because a bandage constituted by the skin substitute is replaced only at intervals of 24 to 48 hours or more, the wound is not traumatised when the skin substitute is replaced and in the meanwhile it is kept sterile. Not only does the skin substitute absorb and inactivate all exudates and necrotic tissues with which it comes into contact, but it prevents a loss of tissue liquids, that is the dehydration of the wound area and the human body in general. It accelerates the granulation of the wounds and leads to a very high success rate when carrying out skin transplantation, 100% success rates not being impossible.
The following example illustrates the invention;~
EXAMPLE
A two layer sheet material was formed of a lower layer which was constituted by a porous foam plastics material, specifically an elastic penopolyurethane of ether or ester type containing 70 to 90% by volume open pores. On top of this was provided an elastomer layer which was microporous, having a thickness of 0.1 to 0.5 mm and being resistant to chemical reagents. The polymer solution from which the polyurethane elastomer upper layer was obtained in a molecular weight above 15,000 had the following constitution:
Parts by
weight
Polyurethane elastomer 20
Dimethylformamide 40
Methylethylketone 20
Toluene 18
Cellulose acetobutyrate 2
The two layer sheet material was obtained by the so-called portable laying down method.Application of the upper layer onto a support surface was first carried out by using a squeegee to apply the polymer solution, the support surface employed having an adhesive surface. Without the need to apply an intermediate coating to the polymer solution, a sheet of foam plastics materials was' applied thereto and then solvent was removed by evaporation in a chamber heated by a current of hot air.
The bandage material thus obtained was automatically cut into pieces 10x25 cm or 12x40 cm. The pieces were impregnated with a solution of cetylpyridinium bromide whose concentration was in the range of 0.01 to 15% by weight and were packed up into polyethylene paper bags which were hermetically closed.
The temporary skin substitute thus produced could be applied clinically for the treatment of extensive wound areas as follows:
Every piece or section of the temporary skin substitute was moistened with a sterile physiological solution and stuck onto the surface of the wound. The sheets were caused to conform well to the affected area to coverthe wound entirely. No further bandage was needed. The skin substitute remained on the wound for from 24to48 hours, in the best cases for 48 hours. Such a time period was sufficient for absorbing the exudates and the hecrotic tissues which appeared at the wound. The wound was clean and sterile after removing the skin substitute and was ready for receiving a skin graft either from the patientorfrom a compatible recently dead body.
Repeated use of the temporary skin substitute of the invention in clinical testing showed consistently good results.
Claims (7)
1. A temporary substitute for human skin, which skin substitute comprises a lower layer for emplacement in contact with a wound and which is formed of a porous foam plastics material having an open pore volume of 70 to 90%, and an upper layer of a microporous synthetic plastics material formed of a polyurethane elastomer having a molecular weight of at least 15,000, the entire skin substitute being impregnated with a 0.01 to 15% by weight solution of an antiseptic agent.
2. A skin substitute as claimed in claim 1, wherein the foam plastics material is a polyether or polyester foam material.
3. A skin substitute as claimed in claim 1 or 2, wherein the polyurethane elastomer has a molecular weight of from 15,000 to 20,000
4. A skin substitute as claimed in any preceding claim, wherein the polyurethane elastomer has a thickness of from 0.1 to 0.5 mm.
5. A skin substitute as claimed in any preceding claim, wherein the antiseptic substance is a quaternary ammonium compound.
6. A skin substitute as claimed in claim 5, wherein the antiseptic substance is cetylpyridinium bromide.
7. A temporary skin substitute for application to human skin, substantially as described in the foregoing Example.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8502028A FR2577133A1 (en) | 1985-02-13 | 1985-02-13 | TEMPORARY SUCCEDANE OF HUMAN SKIN |
GB08503654A GB2170713B (en) | 1985-02-13 | 1985-02-13 | Human skin substitute for temporary use |
CH672/85A CH668179A5 (en) | 1985-02-13 | 1985-02-14 | DOUBLE-LAYER FILM ENVELOPE AND METHOD FOR THE PRODUCTION THEREOF. |
DE19853505853 DE3505853A1 (en) | 1985-02-13 | 1985-02-20 | PROVISIONAL REPLACEMENT OF HUMAN SKIN |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08503654A GB2170713B (en) | 1985-02-13 | 1985-02-13 | Human skin substitute for temporary use |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8503654D0 GB8503654D0 (en) | 1985-03-13 |
GB2170713A true GB2170713A (en) | 1986-08-13 |
GB2170713B GB2170713B (en) | 1988-10-05 |
Family
ID=10574398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08503654A Expired GB2170713B (en) | 1985-02-13 | 1985-02-13 | Human skin substitute for temporary use |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH668179A5 (en) |
DE (1) | DE3505853A1 (en) |
FR (1) | FR2577133A1 (en) |
GB (1) | GB2170713B (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2577133A1 (en) * | 1985-02-13 | 1986-08-14 | Tpo Pharmachim | TEMPORARY SUCCEDANE OF HUMAN SKIN |
EP0265906A2 (en) * | 1986-10-31 | 1988-05-04 | Nippon Zeon Co., Ltd. | Wound dressing |
EP0416702A1 (en) * | 1989-09-06 | 1991-03-13 | H.C. Implants B.V. | Artificial skin |
GB2267427A (en) * | 1992-06-05 | 1993-12-08 | Isabel Maria Reis | Treating burns |
EP1493452A2 (en) * | 2003-06-18 | 2005-01-05 | Corpura B.V. | Antimicrobially active flexible hydrophilic polyurethane foam |
WO2009106498A1 (en) * | 2008-02-27 | 2009-09-03 | Basf Se | Multi-layer composite materials comprising a foam layer, corresponding method of production and use thereof |
US8147857B2 (en) | 2004-12-21 | 2012-04-03 | Bayer Innovation Gmbh | Infection-resistant polyurethane foams, method for producing the same and use thereof in antiseptic wound dressings |
US8962662B2 (en) | 2011-11-15 | 2015-02-24 | Byocoat Enterprises, Inc. | Antimicrobial compositions and methods of use thereof |
US9393158B2 (en) | 2011-08-25 | 2016-07-19 | Brightwake Limited | Non-adherent wound dressing |
US10086107B2 (en) | 2006-04-03 | 2018-10-02 | Brightwake Limited | Adhesive laminates and applications thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8801741A (en) * | 1988-07-08 | 1990-02-01 | Utermoehlen Nv | ART SKIN. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2103590C3 (en) * | 1970-01-28 | 1974-05-16 | Parke, Davis & Co., Detroit, Mich. (V.St.A.) | Medical wound dressing |
DE2140491A1 (en) * | 1971-08-12 | 1973-02-22 | Pawlowa | Bactericidal compsns - contg a quaternary base, a filmogenic polymer and a solvent |
BE789739A (en) * | 1971-10-05 | 1973-04-05 | Lock Peter M | SURGICAL DRESSING |
US3849238A (en) * | 1972-04-07 | 1974-11-19 | S Ronel | Artificial skin |
US4060081A (en) * | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
US3972328A (en) * | 1975-07-28 | 1976-08-03 | E. R. Squibb & Sons, Inc. | Surgical bandage |
DE2845686A1 (en) * | 1977-07-28 | 1979-04-05 | Schwarzheide Synthesewerk Veb | METHOD OF MANUFACTURING A MEDICAL Wound Dressing |
DE3035037A1 (en) * | 1980-09-17 | 1982-04-22 | Fa. Carl Freudenberg, 6940 Weinheim | Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances |
GB2102012B (en) * | 1981-07-02 | 1984-11-21 | Peter Maurice Lock | Wound dressing material |
FR2524304B1 (en) * | 1982-03-31 | 1985-06-14 | Delalande Sa | ARTIFICIAL SKIN |
DE3302984C2 (en) * | 1983-01-29 | 1986-05-22 | Sorbexx GmbH Gesellschaft für Adsorptionstechnik und Verbundstoffe, 8586 Gefrees | Wound cover material in sheet form |
GB2170713B (en) * | 1985-02-13 | 1988-10-05 | Tpo Pharmachim | Human skin substitute for temporary use |
-
1985
- 1985-02-13 GB GB08503654A patent/GB2170713B/en not_active Expired
- 1985-02-13 FR FR8502028A patent/FR2577133A1/en active Pending
- 1985-02-14 CH CH672/85A patent/CH668179A5/en not_active IP Right Cessation
- 1985-02-20 DE DE19853505853 patent/DE3505853A1/en not_active Withdrawn
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2577133A1 (en) * | 1985-02-13 | 1986-08-14 | Tpo Pharmachim | TEMPORARY SUCCEDANE OF HUMAN SKIN |
EP0265906A2 (en) * | 1986-10-31 | 1988-05-04 | Nippon Zeon Co., Ltd. | Wound dressing |
EP0265906A3 (en) * | 1986-10-31 | 1991-10-02 | Nippon Zeon Co., Ltd. | Wound dressing |
EP0416702A1 (en) * | 1989-09-06 | 1991-03-13 | H.C. Implants B.V. | Artificial skin |
US5147401A (en) * | 1989-09-06 | 1992-09-15 | H.C. Implants B.V. | Artificial skin |
GB2267427A (en) * | 1992-06-05 | 1993-12-08 | Isabel Maria Reis | Treating burns |
EP1493452A2 (en) * | 2003-06-18 | 2005-01-05 | Corpura B.V. | Antimicrobially active flexible hydrophilic polyurethane foam |
EP1493452A3 (en) * | 2003-06-18 | 2005-04-20 | Corpura B.V. | Antimicrobially active flexible hydrophilic polyurethane foam |
US8147857B2 (en) | 2004-12-21 | 2012-04-03 | Bayer Innovation Gmbh | Infection-resistant polyurethane foams, method for producing the same and use thereof in antiseptic wound dressings |
US10086107B2 (en) | 2006-04-03 | 2018-10-02 | Brightwake Limited | Adhesive laminates and applications thereof |
WO2009106498A1 (en) * | 2008-02-27 | 2009-09-03 | Basf Se | Multi-layer composite materials comprising a foam layer, corresponding method of production and use thereof |
US8486522B2 (en) | 2008-02-27 | 2013-07-16 | Basf Se | Multi-layer composite materials comprising a foam layer, corresponding method of production and use thereof |
US9393158B2 (en) | 2011-08-25 | 2016-07-19 | Brightwake Limited | Non-adherent wound dressing |
US8962662B2 (en) | 2011-11-15 | 2015-02-24 | Byocoat Enterprises, Inc. | Antimicrobial compositions and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
CH668179A5 (en) | 1988-12-15 |
FR2577133A1 (en) | 1986-08-14 |
DE3505853A1 (en) | 1986-08-21 |
GB8503654D0 (en) | 1985-03-13 |
GB2170713B (en) | 1988-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |