DE3035037A1 - Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances - Google Patents

Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances

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Publication number
DE3035037A1
DE3035037A1 DE19803035037 DE3035037A DE3035037A1 DE 3035037 A1 DE3035037 A1 DE 3035037A1 DE 19803035037 DE19803035037 DE 19803035037 DE 3035037 A DE3035037 A DE 3035037A DE 3035037 A1 DE3035037 A1 DE 3035037A1
Authority
DE
Germany
Prior art keywords
wound
pores
mantle
pref
fibers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803035037
Other languages
German (de)
Inventor
Klaus Dipl.-Phys. Dr. 6945 Hirschberg Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carl Freudenberg KG
Original Assignee
Carl Freudenberg KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carl Freudenberg KG filed Critical Carl Freudenberg KG
Priority to DE19803035037 priority Critical patent/DE3035037A1/en
Publication of DE3035037A1 publication Critical patent/DE3035037A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Abstract

New wound covering consists of hydrophobic fibres physically bound to one another. At least in part, the fibres are coated fibres having an open-pored, foamed mantle and an unfoamed fibre core, the pores of the mantle being filled with a substance which promotes wound healing. The mantle and the fibre cores of the hydrophobic fibres pref. consist of the same polymeric material, pref. a polycarbonate. The pores of the mantle generally have a dia. of 0.01-0.5 micron, pref. 0.05-0.2 micron and the sum of the cross-sections of the pores is generally 1-95% (pref. 10-70%) of the surface area of the mantle. Wound covering, pref. for use as a covering layer on an absorbent wound dressing. The new covering is permeable to fluids secreted by the body, effectively prevents adhesion of the dressing to the wound, and positively influences the healing process.

Description

Wundauflage aus hydrophoben FasernWound pad made of hydrophobic fibers

Die Erfindung betrifft eine Wundauflage aus hydrophoben Fasern, die untereinander physikalisch gebunden sind, vorzugsweise zur Verwendung als Abdeckschicht auf einem saugfähigen Wundverband.The invention relates to a wound dressing made of hydrophobic fibers which are physically bonded to one another, preferably for use as a cover layer on an absorbent wound dressing.

Wundverbände haben den Zweck, eine offene Verletzung vor einer mechanischen :Beschädigung oder einer Verunreinigung zu schützen, und gleichzeitig das aus der Wunde austretende Sekret aufzunehmen und in sich zu speichern, um dadurch die Wundheilung zu fördern.The purpose of wound dressings is to protect an open injury from a mechanical one : To protect damage or contamination, and at the same time get out of the Absorb secretion emerging from the wound and store it in itself, thereby promoting wound healing to promote.

übliche Wundverbände bestehen aus einer Saugschicht aus Zellulose, die auf der der Wunde zugewandten Oberfläche mit einer Wundauflage aus hydrophoben Fasern abgedeckt ist, um zu verhindern, daß die Saugschicht während des Heilungsprozesses mit der Wunde verklebt.Common wound dressings consist of a cellulose absorbent layer, those on the surface facing the wound with a hydrophobic wound pad Fibers are covered to prevent the absorbent layer from breaking during the healing process stuck to the wound.

Dabei muß zwangsläufig eine Beeinträchtigung der Saugwirkung der Saugschicht in Kauf genommen werden. Gemäß DE-OS 27 22 860 wurde deshalb bereits vorgeschlagen, die aus hydrophoben Fasern bestehende Wundauflage zusätzlich mit einem Netzmittel zu behandeln. In Hinblick auf die Notwenigkeit, diesbezüglich eine Substanz auszuwählen, die einerseits ausreichend fest an den glattflächigen, hydrophoben Fasern haftet, und die andererseits in physiologischer Hinsicht unbedenklich ist, verbleiben hinsichtlich der Auswahl nur sehr wenige Möglichkeiten. Eine grundsätzliche Verbesserung der bestehenden Situation konnte deshalb auch durch die Verwendung entsprechender Wundverbände nicht erzielt werden.In this case, the suction effect of the absorbent layer must inevitably be impaired be accepted. According to DE-OS 27 22 860, it has therefore already been proposed the wound pad, consisting of hydrophobic fibers, additionally with a wetting agent to treat. In view of the need to select a substance in this regard, the one hand sufficiently firm on the smooth, hydrophobic Fibers adheres, and which on the other hand is physiologically harmless, there are very few options left in terms of selection. A fundamental one The existing situation could therefore also be improved by using appropriate wound dressings cannot be achieved.

Der Erfindung liegt die Aufgabe zugrunde, eine Wundauflage insbesondere zur Verwendung als Abdeckschicht für saugfähige Wundverbände zu entwickeln, die bei einer guten Durchlässigkeit für vom Körper ausgeschiedene Flüssigkeiten zuverlässig ein Verkleben des Verbandes mit der Wunde verhindert, und die den Heilungsprozess positiv beeinfluß.The invention is based on the object of a wound dressing in particular for use as a cover sheet for absorbent wound dressings to develop the reliable with good permeability for fluids excreted by the body prevents the dressing from sticking to the wound and prevents the healing process positive influence.

Diese Aufgabe wird bei einer Wundauflage der eingangs genannten Art dadurch gelöst, daß die Fasern wenigstens teilweise Mantel fasern mit einem offenporig geschäumten Material und einem ungeschäumten Faserkern sind, wobei die Poren des Mantels mit einer die Wundheilung fördernden Substanz gefüllt sind.This task is performed with a wound dressing of the type mentioned at the beginning solved in that the fibers at least partially sheath fibers with an open pore foamed material and an unfoamed fiber core, the pores of the Mantle are filled with a wound healing promoting substance.

Der Mantel und der Kern der Mantel fasern bestehen aus dem selben polymeren Werkstoff, vorzugsweise aus Polycarbonat. Sie zeichnen sich in diesem Falle durch eine besonders große Weichheit und Verformbarkeit aus, wodurch sich ein entsprechend ausgebildeter Wundverband besonders eng an die zu schützende Oberfläche einer offenen Wunde anschmiegt. Austretendes Körpersekret wird deshalb in allen Bereichen gleichgünstig aufgenommen und in die hinter der Wundauflage angeordnete Speicherschicht eingelagert.The sheath and the core of the sheath fibers consist of the same polymeric material, preferably made of polycarbonate. You excel in this Fall out due to a particularly great softness and deformability, which makes an appropriately designed wound dressing particularly close to the surface to be protected hugs an open wound. Any leaking body secretion is therefore in everyone Areas equally favorably received and arranged in the one behind the wound pad Storage layer incorporated.

Andere polymere Werkstoffe, die sich vorteilhaft zur Herstellung der Wundauflage eignen, sind: Polystyrol, Polyolefin und Polyurethan.Other polymeric materials that are beneficial for the manufacture of the Suitable wound dressings are: polystyrene, polyolefin and polyurethane.

Die Wundauflage kann aus Fasern unterschiedlichen Durchmessers und unterschiedlicher Querschnittsform zusammengesetzt sein, was sich positiv auf die Oberflächenelastizität auswirkt. Im allgemeinen wird es jedoch bevorzugt, die Wundauflage aus Fasern gleichen Durchmessers und-gleicher Querschnittsform herzustellen, vorzugsweise aus Fasern mit einem bandförmigen, flachen Profil. Insbesondere Fasern dieser Art eignen sich ausgezeichnet für die vollständige Abdeckung hervorstehender Faserenden oder -schlaufen aus der Oberfläche der abgedeckten Saugschicht, wobei die Gleichmäßigkeit der Faserverteilung ein hervorzuhebender Vorteil ist. Vorstehende Faserbestandteile werden dadurch eingebunden und können nicht mehr in die Wunde einwachsen. Gleichzeitig ergibt sich eine verbesserte Kapillarwirkung zwischen den flach aufeinander abgelegten Mantel fasern, was zu einem verbesserten Feuchtigkeitstransport von der Wunde in das Innere der Saugschicht beiträgt.The wound pad can be made of fibers of different diameters and diameters be composed of different cross-sectional shape, which has a positive effect on the Surface elasticity affects. In general, however, it is preferred to use the wound dressing from fibers of the same diameter and cross-sectional shape, preferably made of fibers with a ribbon-shaped, flat profile. Especially fibers of this type are excellent for completely covering protruding fiber ends or loops from the surface of the covered absorbent layer, the evenness the fiber distribution is an advantage to be emphasized. The foregoing fiber components are thereby involved and can no longer grow into the wound. Simultaneously this results in an improved capillary action between the layers laid flat on top of one another Coat fibers, resulting in improved moisture transport from the wound in the inside of the absorbent layer contributes.

Die Fasern der Wundauflage können durch: eine Punktschweißung verbunden sein, derart, daß die Fasersubstanz aller Fasern in diskret verteilten Flächenbereichen voll kommen erschmolzen wird. Die einzelnen Fasern sind die .so erhaltenen fensterähnlichen Flächengebilde einige bunden und liegen in den Zwischenräumen vollkommen lose aufeinander auf, Eine solche Wundauflage zeichnet sich durch eine gute Geschmeidigkeit aus.The fibers of the wound pad can be connected by: a spot weld be such that the fiber substance of all fibers in discretely distributed surface areas come fully melted. The individual fibers are the window-like ones obtained in this way Some flat structures are bound and lie completely loosely on top of one another in the spaces between them on, Such a wound dressing is characterized by good suppleness.

Eine verbesserte Saugfähigkeit wird demgegenüber erhalten, wenn die Fasern unter Vermeidung einer Zerstörung ihrer Identität fest verpresst werden, was zwischen glatten Stahlwalzen oder -platten geschehen kann.In contrast, improved absorbency is obtained if the Fibers are firmly pressed while avoiding their identity being destroyed, what can happen between smooth steel rollers or plates.

Die Temperatur soll unterhalb des Erweichungspunktes liegen. Die ausgezeichnete Festigkeit ist z.T. auf die große Oberflächenaktivität der Fasern zurückzuführen, z.T. auf die Porenstruktur des Mantels.The temperature should be below the softening point. The excellent Strength is partly due to the high surface activity of the fibers, partly on the pore structure of the jacket.

Die sehr gleichmäßigen und runden Poren des geschäumten Mantels der Mantelfasern haben -einen Durchmesser von 0,01 bis 0,5 }i, vorzugsweise einen Durchmesser von 0,05 bis 0,2 , wobei die Summe der Querschnitte der Poren 1 bis 99 % der Oberfläche des Mantels überdecken kann, bevorzugt 10 bis 70 %. Die Porenverteilung und Größe ist relativ gleichbleibend in allen Bereichen des Mantels, wobei die Gestalt bei einer Anordnung überwiegend senkrecht zur Oberfläche des Mantels als in etwa zylindrisch angegeben werden kann. Der flächenmäßige Anteil des Mantels am Profil der Mantel fasern beträgt 40 bis 80 %, vorzugsweise 60 %. Das Porenvolumen eignet sich dadurch besonders gut für die Aufnahme verschiedenster, die Wundheilung fördernder Substanzen, die beispielsweise im Rahmen eines Imprägniervorganges eingebracht werden können.The very even and round pores of the foamed shell of the Sheath fibers have a diameter of 0.01 to 0.5} i, preferably a diameter from 0.05 to 0.2, the sum of the cross-sections of the pores 1 can cover up to 99% of the surface of the jacket, preferably 10 to 70%. the Pore distribution and size is relatively constant in all areas of the jacket, wherein the shape in an arrangement predominantly perpendicular to the surface of the shell can be specified as approximately cylindrical. The area proportion of the mantle on the profile of the jacket fibers is 40 to 80%, preferably 60%. The pore volume is therefore particularly well suited for the recording of a wide variety of wound healing promoting substances that are introduced, for example, as part of an impregnation process can be.

Besonders geeignet sind die folgenden Stoffe: Antimikrobiologisch wirkende Stoffe wie Antibiotica, Sulfonamide, Antimykoti ca Proteolytische Substanzen wie z.B. Trypsin Lokalanalgetische Substanzen wie z.B. Lidocain Entzij ndung sheminende Substanzen wie z.B. Corticoide.The following substances are particularly suitable: Antimicrobiological active substances such as antibiotics, sulfonamides, antimycotics, proteolytic substances such as trypsin local analgesic substances such as lidocaine inflammation sheminers Substances such as corticoids.

Aufgrund ihrer geringen Größe sind die Poren relativ formstabil, was wesentlich dazu beiträgt, daß die eingelagerten Substanzen nur langsam gelöst und für die Wundheilung aktiviert werden. Die vorgeschlagene Wundauflage eignet sich aus diesem Grunde ausgezeichnet fiir die Herstellung von Langzeitverbänden, die beispielsweise für die Behandlung von Brandwunden benötigt werden.Due to their small size, the pores are relatively dimensionally stable, what contributes significantly to the fact that the stored substances are only slowly dissolved and activated for wound healing. The proposed wound dressing is suitable therefore excellent for the production of long-term dressings that for example for the treatment of burn wounds are required.

Die Mantel fasern sind vorzugsweise Mikrofasern mit einem größten Durchmesser von 1 bis 20 S. Das Flächengewicht der Wundauflage ist abhängig von dem Grad der Unebenheiten der der Wunde zugewandten Seite der Saugschicht. Bei üblichen Saugschichten auf Zellwollbasis hat 2 sich ein Wert von 5 bis 100 g/m2 bewährt, wobei eine Größenordnung zwischen 10 und 40 g/m2 bevorzugt wird.The sheath fibers are preferably microfibers with a largest Diameter from 1 to 20 S. The weight per unit area of the wound dressing depends on the degree of unevenness on the side of the absorbent layer facing the wound. With usual Absorbent layers based on cellulose wool have a proven value of 5 to 100 g / m2, an order of magnitude between 10 and 40 g / m2 is preferred.

Die in der Anlage beigefügte Zeichnung nimmt in Figur 1 Bezug auf eine Mantelfaser der erfindungsgemäß verwandten Art, in Figur 2 auf die selbe Faser in quergeschnittener Darstellung. Der Maßstab beträgt im ersten Falle 7000 : 1, im letzten Falle 14000 : 1.The drawing attached in the annex refers to FIG a sheath fiber of the type related to the invention, in FIG same Fiber in cross-section. In the first case, the scale is 7000 : 1, in the latter case 14,000: 1.

Claims (4)

Patentansprüche 1. Wundauflage aus hydrophoben Fasern, die untereinander physikalisch gebunden sind, vorzugsweise zur Verwendung als Abdeckschicht auf einem saugfähigen Wundverband, dadurch gekennzeichnet, daß die Fasern wenigstens teilweise Mantel fasern mit einem offenporig geschäumen Mantel und einem ungeschäumten Fase'kern sind, und daß die Poren des Mantels mit einer die Wundheilung fördernden Substanz gefüllt sind.Claims 1. Wound pad made of hydrophobic fibers that intermingle are physically bound, preferably for use as a cover layer on a absorbent wound dressing, characterized in that the fibers are at least partially Sheath fibers with an open-pore foamed sheath and an unfoamed bevel core are, and that the pores of the jacket with a wound healing promoting substance are filled. 2. Wundauflage nach Anspruch 1, dadurch gekennzeichnet, daß der Mantel und der Faserkern aus dem selben polymeren Werkstoff bestehen, vorzugsweise aus Polycarbonat.2. Wound dressing according to claim 1, characterized in that the jacket and the fiber core consist of the same polymeric material, preferably of Polycarbonate. 3. Wundauflage nach Anspruch 1 bis 2, dadurch gekennzeichnet, daß die die Wundheilung fördernden Stoffe eine antimikrobiologisch wirkende, eine proteolytische, lokalanalgetische oder entzündungshenlmende Substanz ist.3. Wound dressing according to claim 1 to 2, characterized in that the substances that promote wound healing have an antimicrobial, proteolytic, is local analgesic or anti-inflammatory substance. 4. Wundauflage nach Anspruch 1 bis 3, dadurch gekennzeichnet, daß die Poren einen Durchmesser von 0,01 bis 0,5 po, vorzugsweise einen Durchmesser von 0,05 bis 0,2 lu haben, und daß die Summe der Querschnitte der Poren 1 bis 95 %, vorzugsweise 10 bis 70 % der Oberfläche des Mantels überdeckt.4. Wound pad according to claim 1 to 3, characterized in that the pores have a diameter of 0.01 to 0.5 po, preferably a diameter from 0.05 to 0.2 lu, and that the sum of the cross sections of the pores 1 to 95 %, preferably 10 to 70% of the surface of the jacket is covered.
DE19803035037 1980-09-17 1980-09-17 Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances Withdrawn DE3035037A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19803035037 DE3035037A1 (en) 1980-09-17 1980-09-17 Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803035037 DE3035037A1 (en) 1980-09-17 1980-09-17 Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances

Publications (1)

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DE3035037A1 true DE3035037A1 (en) 1982-04-22

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DE19803035037 Withdrawn DE3035037A1 (en) 1980-09-17 1980-09-17 Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505853A1 (en) * 1985-02-13 1986-08-21 TPO "Pharmachim", Sofia PROVISIONAL REPLACEMENT OF HUMAN SKIN
EP0238839A2 (en) * 1986-02-27 1987-09-30 Röhm Pharma GmbH Wound covering having a high absorption capacity, based on a polysaccharide as the carrier of a non-immobilized enzyme with a therapeutic activity
DE19631421A1 (en) * 1996-08-06 1998-02-12 Beiersdorf Ag Antimicrobial wound dressings

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505853A1 (en) * 1985-02-13 1986-08-21 TPO "Pharmachim", Sofia PROVISIONAL REPLACEMENT OF HUMAN SKIN
EP0238839A2 (en) * 1986-02-27 1987-09-30 Röhm Pharma GmbH Wound covering having a high absorption capacity, based on a polysaccharide as the carrier of a non-immobilized enzyme with a therapeutic activity
EP0238839A3 (en) * 1986-02-27 1990-04-11 Röhm Pharma GmbH Wound covering having a high absorption capacity, based on a polysaccharide as the carrier of a non-immobilized enzyme with a therapeutic activity
DE19631421A1 (en) * 1996-08-06 1998-02-12 Beiersdorf Ag Antimicrobial wound dressings
US6160196A (en) * 1996-08-06 2000-12-12 Beiersdorf Ag Antimicrobial wound coverings
DE19631421C2 (en) * 1996-08-06 2002-07-18 Beiersdorf Ag Antimicrobial wound dressings

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