DE3505853A1 - PROVISIONAL REPLACEMENT OF HUMAN SKIN - Google Patents

Description

TEMPORARY REPLACEMENT OF HUMAN SKIN

The invention relates to a temporary replacement of the human skin, which is used to cover large, predominantly used by wound surfaces caused by burning.

It is known that when treating large burn wound areas, the open wound is covered with large gauze dressings which are soaked with silver nitrate, unguenta and others. These associations are often changed because they do not represent a barrier for the pathogenic microorganisms. This way the wound is not protected from secondary infections protected; complications are common, and in severe cases the mortality is high. This way of treatment so does not solve the main problem - a rapid restoration of the wholeness of the patient's skin, since the subsequent skin grafting is in most cases unsuccessful.

The treatment of large wound areas is also known, in which human skin is used as a temporary replacement Two-layer envelope is used, the lower layer of which is a porous foam and the upper layer of a represents microporous synthetic matter. This envelope is placed on the wound surface and every two to four Changed hours.

The disadvantages of this two-layer envelope are that the dressing has to be changed very often, whereby the Wound is additionally traumatized. The lower microporous layer absorbs the exudates, but it has none antiseptic properties, as a result of which secondary infections occur due to the adsorbed exudate. When the envelope If not changed in time, the bleeding may be quite heavy, which is an unfavorable influence on further treatment of the wound.

The object of the invention was now to provide a temporary replacement of human skin for the treatment of large wound areas to work out, which does not have to be replaced before the expiry of 24 to 48 hours, no secondary Infection allows, to a 100% transplantation of cadaver and own skin and the exudates and adsorbs the necrotic tissue.

The object according to the invention was achieved, as can be seen from the preceding claim, by a provisional one Replacement of human skin in the form of a two-layer film envelope, or with a lower layer of one elastic porous foam (of the ether or ester type) with 70 to 90% open pores and a top layer with a thickness of 0.1 to 0.5 mm and great elasticity, a polyurethane elastomer with a molecular weight of over 15,000. The polyurethane elastomer layer was made from a polyurethane solution in an organic solvent, namely dimethylformamide, ethyl methyl ketone, toluene and / or cellulose acetobutyrate. The "cloth" created is with a 0.1 to 15% solution of the antiseptic cetylpyridine bromide impregnated.

The advantages of the temporary human skin replacement of the present invention are as follows.

The bandage is changed in a period of 24 to 48 hours, which means that the wound is not traumatized and remains sterile. It absorbs and inactivates all exudates and necrotic tissues. It prevents the loss of tissue fluids, i.e. the dehydration of the wound surfaces and the human body. It accelerates the granulation of the wounds and ensures 100% transplantation of the grafts.

example

The 5äWt; i tu; hichtiyu FoI lemutUK'h l «uj bfnteht at a lower one

3506853

Layer of a porous foam made of elastic foam polyurethane (of the ether or ester type) and Contains 70 to 90% open pores, and a top (surface) layer that is microporous and 0.1 thick up to 0.5 mm, and is elastic and resistant to chemical reagents. The polymer solution, out which is the polyurethane elastomer with a molecular weight of over 15000 is produced, has the following composition:

Polyurethane elastomer 20 parts by weight

Dimethylformamide 40 parts by weight

Methyl ethyl ketone 20 parts by weight

Toluene 18 parts by weight

Cellulose acetobutyrate 2 parts by weight

The temporary replacement of human skin is carried out according to the so-called transferable method of application made. The upper layer is formed by applying a squeegee on a carrier with an adhesive surface, a "wet" application without intermediate adhesive to the polymer solution, a Foam foil and solvent removal by evaporation in a chamber with hot air heating. The manufactured "Cloth" is automatically cut into 10/25 or 12/40 cm pieces with a 0.01 to 15% cetylpyridine bromide solution impregnated, then dried and packed in hermetically sealed polyurethane paper bags.

The temporary replacement of human skin is used clinically to treat large areas of wounds in the following ways:

Each "foil" of the temporary replacement of human skin is moistened with a sterile, physiological solution and applied the wound surface is glued. In this way, the foils are placed close together until the wound surface is completely covered. It will no additional bandage applied. The temporary replacement stays on the for 24 to 48 hours (48 hours ideally) Wound, while the exudates and necrotic tissue are adsorbed

be beer. The wounds are clean and sterile. After removing the foils, the wounds are ready for transplantation of cadaver skin, other skin or own skin ready.

Applied in clinics, the inventive provisional Replacement of human skin gives very good results.

Claims (1)

V. FÜNER EBBINGHAUS FINCK PATENT LAWYERS EUROPEAN PATENT ATTORNEYS MARIAHILFPLATZ 2 & 3, MÖNCHEN ΘΟ POST ADDRESS: POSTBOX 95 OI βθ, D-8OOO MÖNCHEN 95 TPO "PHARMACHIM" DEAA-32578.0 February 20, 1985 TEMPORARY REPLACEMENT OF HUMAN SKIN P aten tan spur Temporary replacement of human skin in the form of a two-layer foil envelope with a lower layer of porous foam and an upper layer of microporous synthetic material, characterized in that the lower layer is made of porous Foam has 70 to 90% open pores and the top layer is a microporous polyurethane elastomer with a Molecular weight of over 15,000 represents, the whole envelope with a 0.01 to 15% strength cetylpyridine bromide solution was impregnated. ?