FR2577133A1 - Temporary substitute for human skin - Google Patents

Temporary substitute for human skin Download PDF

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Publication number
FR2577133A1
FR2577133A1 FR8502028A FR8502028A FR2577133A1 FR 2577133 A1 FR2577133 A1 FR 2577133A1 FR 8502028 A FR8502028 A FR 8502028A FR 8502028 A FR8502028 A FR 8502028A FR 2577133 A1 FR2577133 A1 FR 2577133A1
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Prior art keywords
skin
human skin
temporary substitute
substitute
temporary
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FR8502028A
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French (fr)
Inventor
Stefan Dobrev Popov
Nikola Alexandrov Vazbazov
Yordan Ivanov Tchervenkov
Todorka Stefanova Ivanova
Venelin Angelov Tashev
Nikolay Tzanev Komarov
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TPO Pharmachim
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TPO Pharmachim
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/00051Accessories for dressings
    • A61F13/00063Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F15/00Auxiliary appliances for wound dressings; Dispensing containers for dressings or bandages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/10Hair or skin implants
    • A61F2/105Skin implants, e.g. artificial skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/425Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/53Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
    • A61F13/534Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/84Accessories, not otherwise provided for, for absorbent pads
    • A61F13/8405Additives, e.g. for odour, disinfectant or pH control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00089Wound bandages
    • A61F2013/00119Wound bandages elastic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00089Wound bandages
    • A61F2013/00157Wound bandages for burns or skin transplants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00089Wound bandages
    • A61F2013/00246Wound bandages in a special way pervious to air or vapours
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00365Plasters use
    • A61F2013/00519Plasters use for treating burn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00902Plasters containing means
    • A61F2013/0091Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/53Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
    • A61F2013/530802Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium characterized by the foam or sponge other than superabsorbent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/53Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
    • A61F13/534Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad
    • A61F2013/53445Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having an inhomogeneous composition through the thickness of the pad from several sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208Quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents

Abstract

L'invention concerne un succédané de la peau humaine pour traitement de plaies de grandes surfaces, qui n'a pas à être remplacé avant un laps de temps de 24 à 48 heures, qui évite les infections secondaires, qui garantit une efficacité à 100% de la transplantation de la peau de cadavre ou de la peau propre du malade et enfin qui absorbe les sudations et le tissu nécrotique. A substitute for human skin for treating large areas wounds, which does not have to be replaced before a period of 24 to 48 hours, which prevents secondary infections, which guarantees 100% effectiveness transplantation of cadaver skin or clean skin of the patient and finally absorbing sweats and necrotic tissue. <BR/> Le succédané temporaire de la peau comprend un élément en feuille à deux couches, l'une inférieure constituée d'une mousse plastique poreuse et l'autre supérieure constituée d'une matière synthétique microporeuse. <BR/> The temporary substitute for the skin comprises a sheet member to two layers, a bottom consisting of a porous foam plastic and the other upper made of a microporous plastic. L'élément en feuille entier étant imprégné d'une solution de bromure de cétylpyridinium ayant de préférence une concentration de 0,01 à 15%. The entire sheet member being impregnated with a cetylpyridinium bromide solution preferably having a concentration of 0.01 to 15%.

Description

2577133. 2577133.

Succédané temporaire de la peau humaine L'invention concerne un succédané temporaire de la peau humaine, appliqué pour le recouvrement de plaies de grande surface causées surtout Temporary substitute for human skin A temporary substitute for human skin, applied for covering large surface area wounds caused mainly

par des brûlures. by burns.

Il1 est connu que lors du traitement d'une plaie de grande sur- face de à des brûlures, la plaie ouverte est recouverte par des pansements à gaze imbibés de nitrate d'argent, d'onguents et autres. Il1 is known that when treating a wound of large sur- face burns, open wound is covered by gauze dressings soaked in silver nitrate, ointments and others. Ces pansements doivent être fréquemment remplacés car ils ne présentent pas un obstacle aux micro-organismes pathogènes. These dressings should be replaced frequently as they do not present a barrier to pathogens. De cette manière, la plaie n'est pas protégée contre les infections secondaires, ce qui entraîne souvent des complications et peut même dans les cas graves augmenter le taux de mortalité. In this way, the wound is not protected against secondary infections, which often leads to complications and may even increase in severe cases mortality. Ce procédé de traitement laisse ouvert le problème fondamental, qui consiste dans la reconstitution accélérée de l'intégrité de la peau du malade, puisque la transplantation ultérieure de la peau dans la plupart des cas reste sans This treatment process leaves open the fundamental problem, which consists in the rapid reconstitution of the integrity of the skin of the patient, since the subsequent transplantation of the skin in most cases remains without

succès. success.

On connalt aussi le traitement des plaies de grande surface dans Also connalt the treatment of large surface wounds in

lequel on utilise comme succédané temporaire de la peau une couverture com- which is used as a temporary substitute for skin coverage com-

prenant deux couches, la couche inférieure étant en une mousse plastique poreuse tandis que la couche supérieure est en une matière synthétique microporeuse. taking two layers, the lower layer being of a porous plastic foam while the upper layer is a microporous synthetic material. La couverture est appliquée sur la surface de la plaie et The cover is applied to the surface of the wound and

renouvelée toutes les 2 à 4 heures. renewed every 2 to 4 hours.

Les inconvénients de cette couverture à deux couches consistent dans le fait qu'il est nécessaire de procéder àun revouvellement fréquent du pansement, ce qui traumatise davantage la plaie. The disadvantages of this coverage to two layers consist in the fact that it is necessary toa common revouvellement dressing, which further traumatize the wound. La couche microporeuse absorbe les sudations, mais ne possède pas de propriétés antiseptiques, et pour cette raison, elle donne naissance à des infections secondaires à la base des sudations absorbées. The microporous layer absorbs sweats, but does not have antiseptic properties, and for that reason it gives rise to secondary infections at the base of the absorbed sweats. Si le remplacement des couvertures n'est pas effectué en temps voulu, on observe un saignement important qui a une If replacing the covers is not made on time, major bleeding was observed that a

conséquence défavorable sur le développement de la plaie. adverse effect on the development of the wound.

Le but de l'invention est la création d'un succédané temporaire de la peau humaine, lors du traitement de plaies de grande surface, qui The object of the invention is to create a temporary substitute for human skin, when processing large surface wounds which

n'a pas à être remplacé avant 24 -48 heures,qui évite les infections se- does not have to be replaced before 24 -48 hours, avoiding infections se-

condaires, qui garantit une efficacité à 100 % de la transplantation de la peau de cadavre ou de la peau propre du malade, enfin qui absorbe les ondary, which guarantees 100% effectiveness of transplantation of cadaver skin or clean skin of the patient, finally absorbs

sudations et le tissu nécrotique. sweating and necrotic tissue.

Le problème posé est résolu au moyen d'un succédané temporaire de la peau humaine, qui comprend un élément en feuille à deux couches, l'une inférieure constituée-d'une mousse élastique plastique et poreuse (du type éther ou ester) contenant de 70 à 90 % de pores ouverts et l'autre supérieure constituée d'une matière microporeuse ayant une épaisseur de 0, 1 The problem posed is solved by a temporary substitute for human skin, which comprises an element in two-layer sheet, one bottom consisting of a plastic-elastic and porous foam (ether or ester) containing 70 to 90% of open pores and the other upper made of a microporous material having a thickness of 0, 1

à 0,5 mm et une grande élasticité, constituée d'un élastomère en polyure- 0.5 mm and high elasticity, formed of an elastomeric polyure-

thane d'un poids molaire supérieur à 15000, notamrnt de 15000 à 20000. La couche de l'élastomère en polyuréthane est obtenue à partir d'une solution thane a molar weight greater than 15000, notamrnt 15000 to 20000. The layer of the polyurethane elastomer is obtained from a solution

de polyuréthane dans des solvants organiques, précisément le diméthyl- polyurethane in organic solvents, specifically dimethyl

formamide, la méthylcétone, le toluène et l'acétobutyrate de cellulose. formamide, methyl ethyl ketone, toluene and cellulose acetate butyrate.

"L'étoffe" obtenue est imprégnée d'une solution d'antiseptique tel que du bromure de cétylpyridinium ayant de préférence une concentration de 0,1 à %. "The fabric" obtained is impregnated with an antiseptic solution such as cetylpyridinium bromide, preferably having a concentration of 0.1%.

Les avantages du succédané temporaire de la peau selon l'inven- The benefits of temporary substitute for the skin according to invention

tion sont les suivants: Le pansement est remplacé périodiquement à un intervalle de 24 tion are as follows: The dressing is changed periodically at an interval of 24

à 48 heures, grâce à quoi la plaie n'est pas traumatisée et demeure stérile. to 48 hours, whereby the wound is not traumatized and unfruitful.

Le pansement absorbe et inactive toutes les sudations et les tissus nécroti- The dressing absorbs and inactivates all sweating and fabrics nécroti-

ques. c. Il empêche la perte des liquides des tissus, c'est-à-dire la déshydrata- It prevents the loss of tissue fluids, that is to say, the dehydration

tion des surfaces des plaies et du corps et accélère la granulation des plaies tion wound surfaces and body and accelerates wound granulation

en garantissant une efficacité à 100 % de la transplantation. ensuring 100% effectiveness of transplantation.

A titre d'exemple, l'invention est illustrée par la réalisation suivante: L'élément en feuille à deux couches comprend une couche inférieure, qui n'est autre chose qu'une mousse plastique poreuse telle qu'une mousse de polyuréthane élastique (du type ester ou éther) contenant 70 à 90 % de pores ouverts, et une couche supérieure (couche superficielle) microporeuse ayant une épaisseur de 0,1 à 0,5 mm, et qui est élastique et résistante à des agents chimiques. For example, the invention is illustrated by the following embodiment: The sheet member two-layer comprises a lower layer, which is other than a porous plastic foam such as a resilient polyurethane foam ( ester type or ether) containing 70 to 90% of open pores, and an upper layer (surface layer) microporous having a thickness of 0.1 to 0.5 mm, and which is resilient and resistant to chemical agents. La solution du polymère à partir de laquelle on obtient l'élastomère en polyuréthane d'un poids molaire supérieur à 15000 possède la composition suivante: Elastomère en polyuréthane 20 parties pondérales Diméthylformamide 40 parties pondérales Méthyléthylcétone 20 parties pondérales Toluene 18 parties pondérales Acétobutyrate de cellulose 2 parties ponderales The polymer solution from which the elastomer is obtained polyurethane of a molecular weight greater than 15,000 has the following composition: Polyurethane elastomer 20 parts by weight Dimethylformamide 40 parts by weight Methyl ethyl ketone 20 parts by weight Toluene 18 parts by weight cellulose acetobutyrate 2 parts by weight

Le succédané temporaire est obtenu selon la méthode d'applica- Temporary substitute is obtained according to the method applica-

tion par report. tion by postponement. La formation de la couche supérieure s'effectue en appli- Forming the upper layer is carried out by applying

quant la solution du polymère sur un support avec une surface adhésive (application "Humide"),-sans la nécessité d'un adhésif intermédiaire sur as the polymer solution on a support with an adhesive surface (application "Wet") - without the need for an intermediate adhesive

la solution du polymère - d'une feuille de la mousse plastique. the polymer solution - of a plastic foam sheet. La sépara- the separation

tion du solvant s'effectue par évaporation dans une chambre à chauffage par of the solvent is effected by evaporating in a heating chamber by

courant d'air chaud. stream of hot air.

"L'étoffe" obtenue est coupée automatiquement en feuilles de format 10 x 25 ou 12 x 40 cm, qui sont imprégnées avec une solution de bromure de cétylpyridinium ayant une concentration de 0,01 à 15 %, séchées "The fabric" is obtained automatically cut format sheets 10 x 25 or 12 x 40 cm, which are impregnated with cetylpyridinium bromide solution having a concentration of 0.01 to 15%, dried

et emballées dans des enveloppes étanches en papier-polyéthylène. and packaged in sealed envelopes paper-polyethylene.

En clinique on applique le succédané temporaire pour le traite- In clinical applying temporary substitute for the treat-

ment des plaies de grande surface de la manière suivante - ment large-area wounds as follows -

Chaque "feuille" est trempée dans une solution physiologique stérile et est collée sur la surface de la plaie. Each "sheet" is soaked in sterile physiological solution and is adhered to the surface of the wound. On arrange les feuilles d'une manière serrée, les unes à côté des autres, jusqu'au recouvrement complet de la plaie. We arrange the leaves of a tight manner, next to each other, until the complete recovery of the wound. Un pansement supplémentaire n'est pas nécessaire. An additional dressing is not necessary. Le succédané demeure sur la plaie pendant un laps de temps de 24 à 48 heures -le mieux pendant 48 heures - temps suffisant pour l'absorption des sudations et des tissus nécrotiques. The substitute remains on the wound for a period of 24 to 48 hours -the best for 48 hours - enough time for absorbing sweats and necrotic tissue. Après l'enlèvement des feuilles, les plaies sont propres et stériles. After removal of the leaves, the wounds are clean and sterile. Elles sont prêtes pour la transplantation de la peau de cadavre They are ready for transplantation of cadaver skin

ou de la peau du patient. or the patient's skin.

Appliqué en clinique, le succédané temporaire de la peau selon Applied clinical, temporary skin substitute according

l'invention procure d'excellents résultats. the invention provides excellent results.

Claims (3)

    REVENDICATIONS
  1. 1. Succédané temporaire de la peau humaine, comprenant un élé- 1. Temporary Substitute human skin, comprising an element
    ment en feuille à deux couches, l'une inférieure constituée d'une mousse ment sheet in two layers, a bottom consisting of a foam
    plastique poreuse et l'autre supérieure constituée d'une matière synthéti- porous plastic and the other upper made of a synthetic material
    que microporeuse, caractérisé en ce que la couche inférieure en mousse plastique poreuse contient de 70 à 90 % de pores ouverts et en ce que la that microporous, characterized in that the lower layer of porous plastic foam contains from 70 to 90% of open pores and in that the
    couche supérieure est constituée d'un élastomère en polyuréthane micro- top layer is made of an elastomeric polyurethane micro-
    poreux, l'élément en feuille étant tout entier imprégné d'une solution de bromure de cétylpyridinium porous, the sheet member being entirely impregnated with a solution of cetylpyridinium bromide
  2. - 2. Succédané temporaire de la peau humaine, selon la revendica- - 2. Temporary Substitute human skin, according to revendica-
    tion 1, caractérisé en ce que le polyuréthane microporeux a un poids molaire tion 1, characterized in that the microporous polyurethane has a molecular weight
    supérieur à 15 000, de préférence compris entre 15 000 et 20 000. more than 15 000, preferably between 15 000 and 20 000.
  3. 3. Succédané temporaire de la peau humaine, selon la revendica- 3. Temporary Substitute human skin, according to revendica-
    tion 1 ou 2, caractérisé en ce que la solution de bromure de céthylpyridinium tion 1 or 2, characterized in that the bromide solution céthylpyridinium
    a une concentration de 0,01 à 15 %. has a concentration of 0.01 to 15%.
FR8502028A 1985-02-13 1985-02-13 Temporary substitute for human skin Pending FR2577133A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8503654A GB2170713B (en) 1985-02-13 1985-02-13 Human skin substitute for temporary use

Publications (1)

Publication Number Publication Date
FR2577133A1 true true FR2577133A1 (en) 1986-08-14

Family

ID=10574398

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8502028A Pending FR2577133A1 (en) 1985-02-13 1985-02-13 Temporary substitute for human skin

Country Status (3)

Country Link
DE (1) DE3505853A1 (en)
FR (1) FR2577133A1 (en)
GB (1) GB2170713B (en)

Cited By (1)

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EP0351016A2 (en) * 1988-07-08 1990-01-17 Koninklijke Utermöhlen N.V. Artificial skin

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FR2577133A1 (en) * 1985-02-13 1986-08-14 Tpo Pharmachim Temporary substitute for human skin
DE3751254D1 (en) * 1986-10-31 1995-05-24 Nippon Zeon Co Wound dressing.
NL8902237A (en) * 1989-09-06 1991-04-02 Hc Implants Bv Artificial skin.
GB9211930D0 (en) * 1992-06-05 1992-07-15 Reis Isabel M Burn aid
EP1493452B1 (en) * 2003-06-18 2010-02-03 Corpura B.V. Antimicrobially active flexible hydrophilic polyurethane foam
DE102004061406A1 (en) 2004-12-21 2006-07-06 Bayer Innovation Gmbh Infection resistant polyurethane foams, method for their preparation and use in antiseptic wound dressings equipped
EP2268483B1 (en) * 2008-02-27 2018-04-11 Basf Se Multi-layer composite materials comprising a foam layer, corresponding method of production and use thereof
GB2493960B (en) 2011-08-25 2013-09-18 Brightwake Ltd Non-adherent wound dressing
US8962662B2 (en) 2011-11-15 2015-02-24 Byocoat Enterprises, Inc. Antimicrobial compositions and methods of use thereof

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FR2077381A1 (en) * 1970-01-28 1971-10-22 Parke Davis & Co
DE2140491A1 (en) * 1971-08-12 1973-02-22 Pawlowa Bactericidal compsns - contg a quaternary base, a filmogenic polymer and a solvent
DE2317081A1 (en) * 1972-04-07 1973-10-31 Nat Patent Dev Corp artificial skin
FR2319326A1 (en) * 1975-07-28 1977-02-25 Squibb & Sons Inc Band surgical dressing
GB2102012A (en) * 1981-07-02 1983-01-26 Peter Maurice Lock Wound dressing material
DE3302984A1 (en) * 1983-01-29 1984-08-02 Sorbexx Gmbh Covering material in ground form
GB2170713A (en) * 1985-02-13 1986-08-13 Tpo Pharmachim Medicated wound dressing

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BE789739A (en) * 1971-10-05 1973-04-05 Lock Peter M surgical dressing
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
DE2845686C2 (en) * 1977-07-28 1988-02-25 Veb Synthesewerk Schwarzheide Kombinat Sys, Ddr 7817 Schwarzheide, Dd
DE3035037A1 (en) * 1980-09-17 1982-04-22 Freudenberg Carl Fa Wound covering esp. as antiadhesive layer for absorbent dressings - comprises coated fibres in which pores of foamed coating contain wound healing promoting substances
FR2524304B1 (en) * 1982-03-31 1985-06-14 Delalande Sa artificial skin

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FR2077381A1 (en) * 1970-01-28 1971-10-22 Parke Davis & Co
DE2140491A1 (en) * 1971-08-12 1973-02-22 Pawlowa Bactericidal compsns - contg a quaternary base, a filmogenic polymer and a solvent
DE2317081A1 (en) * 1972-04-07 1973-10-31 Nat Patent Dev Corp artificial skin
FR2319326A1 (en) * 1975-07-28 1977-02-25 Squibb & Sons Inc Band surgical dressing
GB2102012A (en) * 1981-07-02 1983-01-26 Peter Maurice Lock Wound dressing material
DE3302984A1 (en) * 1983-01-29 1984-08-02 Sorbexx Gmbh Covering material in ground form
GB2170713A (en) * 1985-02-13 1986-08-13 Tpo Pharmachim Medicated wound dressing

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0351016A2 (en) * 1988-07-08 1990-01-17 Koninklijke Utermöhlen N.V. Artificial skin
EP0351016A3 (en) * 1988-07-08 1991-01-02 Koninklijke Utermöhlen N.V. Artificial skin
US4985036A (en) * 1988-07-08 1991-01-15 Koninklijke Utermohlin N.V. Artificial skin

Also Published As

Publication number Publication date Type
GB2170713B (en) 1988-10-05 grant
GB8503654D0 (en) 1985-03-13 grant
GB2170713A (en) 1986-08-13 application
DE3505853A1 (en) 1986-08-21 application

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