GB2155176B - Sequencing dna - Google Patents

Sequencing dna

Info

Publication number
GB2155176B
GB2155176B GB08500960A GB8500960A GB2155176B GB 2155176 B GB2155176 B GB 2155176B GB 08500960 A GB08500960 A GB 08500960A GB 8500960 A GB8500960 A GB 8500960A GB 2155176 B GB2155176 B GB 2155176B
Authority
GB
United Kingdom
Prior art keywords
sequencing dna
sequencing
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08500960A
Other versions
GB2155176A (en
GB8500960D0 (en
Inventor
Leroy E Hood
Michael W Hunkapiller
Lloyd M Smith
Tim J Hunkapiller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of GB8500960D0 publication Critical patent/GB8500960D0/en
Publication of GB2155176A publication Critical patent/GB2155176A/en
Application granted granted Critical
Publication of GB2155176B publication Critical patent/GB2155176B/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
GB08500960A 1984-01-16 1985-01-15 Sequencing dna Expired GB2155176B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57097384A 1984-01-16 1984-01-16
US68901385A 1985-01-02 1985-01-02

Publications (3)

Publication Number Publication Date
GB8500960D0 GB8500960D0 (en) 1985-02-20
GB2155176A GB2155176A (en) 1985-09-18
GB2155176B true GB2155176B (en) 1988-05-11

Family

ID=27075453

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08500960A Expired GB2155176B (en) 1984-01-16 1985-01-15 Sequencing dna

Country Status (5)

Country Link
CA (1) CA1258611A (en)
DE (1) DE3501306C2 (en)
FR (1) FR2558262B1 (en)
GB (1) GB2155176B (en)
SE (1) SE456348B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4865968A (en) * 1985-04-01 1989-09-12 The Salk Institute For Biological Studies DNA sequencing
US4855225A (en) * 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4811218A (en) * 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
DE3618605A1 (en) * 1986-06-03 1987-12-10 Europ Lab Molekularbiolog DEVICE FOR DETECTING SUBSTANCES INCENTIVELY TO PHOTON EMISSION
DE3621631A1 (en) * 1986-06-27 1988-01-14 Hirschmann Geraetebau Gmbh & C DEVICE FOR IMAGING AN OBJECT ON AN ELECTROOPTIC CONVERTER
US5242796A (en) * 1986-07-02 1993-09-07 E. I. Du Pont De Nemours And Company Method, system and reagents for DNA sequencing
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
JPH0799353B2 (en) * 1987-03-31 1995-10-25 株式会社島津製作所 Nucleotide sequencer
EP0294524B1 (en) * 1987-06-09 1997-11-26 The Perkin-Elmer Corporation Real time scanning electrophoresis apparatus for DNA sequencing
US4833332A (en) * 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
US5102785A (en) * 1987-09-28 1992-04-07 E. I. Du Pont De Nemours And Company Method of gene mapping
JPH01224657A (en) * 1988-03-04 1989-09-07 Hitachi Ltd Device for determining base sequence of nucleic acid
EP0341928A1 (en) * 1988-05-10 1989-11-15 AMERSHAM INTERNATIONAL plc Improvements relating to surface plasmon resonance sensors
SE8802573D0 (en) * 1988-07-08 1988-07-08 Wallac Oy MULTI-LABEL TIME-RESOLVED FLUORESCENCE ANALYSIS OF NUCLEIC ACID SEQUENCES USING LANTHANIDE CHELATES
FR2636739B1 (en) * 1988-09-20 1993-02-12 Commissariat Energie Atomique METHOD AND INSTALLATION FOR IDENTIFYING THE BASES OF DNA
FR2636738B1 (en) * 1988-09-20 1992-12-11 Commissariat Energie Atomique DNA SEQUENCING PROCESS AND INSTALLATION
US5061361A (en) * 1989-03-06 1991-10-29 Hewlett-Packard Company Capillary zone electrophoresis cell system
FR2649487B1 (en) * 1989-06-21 1991-09-20 Europhor Sa ELECTROPHORESIS CAPILLARY WITH INCORPORATED OPTICAL DEVICE
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
FR2671407B1 (en) * 1991-01-08 1994-08-05 Europhor Sa METHOD OF ANALYSIS BY CAPILLARY ELECTROPHORESIS WITH FLUORESCENCE DETECTION, AND DEVICES FOR IMPLEMENTING SAME.
US5203339A (en) * 1991-06-28 1993-04-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Health And Human Services Method and apparatus for imaging a physical parameter in turbid media using diffuse waves
US5273638A (en) * 1991-09-30 1993-12-28 Beckman Instruments, Inc. Nucleotide sequence determination employing matched dideoxynucleotide terminator concentrations
EP0539743B1 (en) * 1991-09-30 1997-08-06 Beckman Instruments, Inc. Enhanced fluorescence detection of samples in capillary column
US5484571A (en) * 1991-10-08 1996-01-16 Beckman Instruments, Inc. Enhanced fluorescence detection of samples in capillary column
WO1993019205A1 (en) * 1992-03-19 1993-09-30 The Regents Of The University Of California Multiple tag labeling method for dna sequencing
JPH05332992A (en) * 1992-05-29 1993-12-17 Shimadzu Corp Electrophoresis device
DE4336911C2 (en) * 1993-10-28 2002-11-21 Biotechnolog Forschung Gmbh Primer production process and template bank therefor
JP3068413B2 (en) * 1994-07-13 2000-07-24 日立電子エンジニアリング株式会社 DNA base sequencer
US5675155A (en) * 1995-04-26 1997-10-07 Beckman Instruments, Inc. Multicapillary fluorescent detection system
US6110683A (en) * 1999-01-08 2000-08-29 Commonwealth Biotechnologies, Inc. Automated DNA Sequencer loading dye which contains a lane tracking aid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1205028A (en) * 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
FR2519005B1 (en) * 1981-12-29 1985-10-25 Pasteur Institut DNA FRAGMENTS MARKED WITH AT LEAST ONE OF THEIR ENDS ENDANGERED BY MODIFIED RIBONUCLEOTIDES RECOGNIZABLE BY AFFINOUS MOLECULES AND METHOD FOR CARRYING OUT ANALYSIS OF SUCH DNA FRAGMENTS
DK105582A (en) * 1982-03-11 1983-09-12 Nordisk Insulinlab PROCEDURE FOR DETERMINING HUMAN HLA-D (R) TISSUE TYPES AND REVERSE FOR USING THE PROCEDURE
US4490472A (en) * 1982-06-17 1984-12-25 Imreg, Inc. Sensitive tests for malignancies based on DNA detection

Also Published As

Publication number Publication date
FR2558262B1 (en) 1989-04-07
GB2155176A (en) 1985-09-18
FR2558262A1 (en) 1985-07-19
CA1258611A (en) 1989-08-22
DE3501306C2 (en) 1998-09-24
SE8500201D0 (en) 1985-01-16
DE3501306A1 (en) 1985-07-25
SE8500201L (en) 1985-07-17
GB8500960D0 (en) 1985-02-20
SE456348B (en) 1988-09-26

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20050114