GB2144991A

GB2144991A - Hair growth promotor

Info

Publication number: GB2144991A
Application number: GB08419228A
Authority: GB
Inventors: Yoshiaki Oshima
Original assignee: Individual
Current assignee: Individual
Priority date: 1983-08-11
Filing date: 1984-07-27
Publication date: 1985-03-20
Also published as: FR2550448B1; JPH0441123B2; CA1240618A; KR860001587B1; JPS6038313A; DE3417136C2; FR2550448A1; GB8419228D0; DE3417136A1; GB2144991B; KR850002395A

Abstract

A topical hair growth preparation involving oestrogens, adrenal homones and vitamin B2 as main ingredients with low concentration and specified ratio of oestrogen to adrenal hormone.

Description

SPECIFICATION Agent for generating the hair BACKGROUND OF THE INVENTION Generally, there are many examples in which the ingredients of agents promoted for curing baldness or generating the hair are oestrogens and adrenal hormones. It has been widely believed that the reason why there are many bald-headed men but few or no bald-headed women is that men tend to have excessive androgens; however, no woman has such a tendency. It is thus clear why there are many examples in which oestrogens are proposed in agents to cure lack of hair, aiming to supplement natural oestrogens in cutaneous organization.

Agents containing oestrogens, with vitamin E or H, alcohol, menthol, etc., as their main ingredients, or those adding vitamin E or H, alcohol, menthol, etc. to adrenal hormones have been known. It is however a fact that these agents have no effect in generating the hair, without exception, yet recognising this fact, people use such ineffective agents with some expectation. Many examples have been found in which inflammations have occurred in the skin as well as failure to show hair growth, or even to cause loss of existing hair.

The inventor has made repeated researches in connection with the status of agents for generating the hair sold in the market as mentioned above, and the use of oestrogens and adrenal hormones certainly has a reasonability from the point of view of their characteristics. However, it was plain to the inventor that many matters remained to be researched for the conditions of use to be elucidated.

Adrenal hormones of a concentration of 0.5 per cent are for example used for circular epilation, but there is a problem of concentration for long term use. The inventor however has tested possibilities in a low concentration range that is not conventionally thought valuable. There is no example in-which oestrogens and adrenal hormones are used together, but the inventor has found the possibility of using them in a specific range of mixing ratios.

There have been some examples of using vitamins as promoting agent for metabolism of proteins, but it is important to search for a combination to demonstrate a precise and strong promoting action in the present context.

THE INVENTION The present invention has been completed as the result of investigations based on the ideas stated above, and provides an agent for generating the hair efficiently by applying it to the human head, without adverse side effects.

Thus there is provided a topical agent that comprises oestrogen 0.0033 to 1.0 mg%(i.e.

mg per 100 cc), adrenal hormone 0.018 to 2.75 mg%, and vitamin B2 from 0.085 up to 25.5 mg% as main ingredients thereof, conveniently dissolved in distilled water as a medium, with an oestrogen/adrenal hormone weight ratio of 0.01 to 4.0.

The following examples illustrate the invention, without limitation.

Example 1.

Embodiment 1 of this invention is as follows: an agent containing oestradiol benzoate (oestrogen) 0.005 mg; prednisolone acetate (adrenal hormone) 0.0275 mg; riboflavine phosphate (vitamin B2) 0.125 mg, and flavine-adenine dinucleotide (vitamin B2) 0.0025 mg asmain ingredients as well as chlorophenylamine maleate (antihistamine) 0.075 mg; pyridoxine hydrochloride (vitamin B6) 0.25 mg; nicotinamide 0.5 mg; pantothenyl alcohol 0.25 mg; and DL-methionine 1.0 mg were uniformly dissolved in refined water 100 cc.

To make this preparation material in liquid form in injection ampoules was used for each of the materials and the purity thereof was essentially 100 per cent. For example, oestra diol benzoate 0.2 mg was in aqueous suspension 1 cc in an ampoule; this liquid was uniformly dissolved in refined water, 4 litres and since this preparation is of a low concentration, the material is perfectly dissolved.

Specific amounts of the other materials contained respectively in 2 cc ampoules were also dissolved uniformly in the said refined water.

Example 2.

Next, as embodiment 2 of this invention, cortisone acetate (adrenal hormone) 0.0275 mg was used instead of the prednisolone acetate in embodiment 1, and the other materials and their quantities were as above.

In use, the agents are applied to the bald areas. Embodiments 1 and 2 give the maximum efficiency among many embodiments tried by the applicant and having effects for yielding the hair. Embodiments 1 and 2 differ only in the kinds of their adrenal hormones, the other conditions being the same; however, the effects for generating the hair of both are the same.

As the result of tests, changing various conditions, the applicant has shown that oestrogens, adrenal hormones and vitamin B2 play the roles of the main ingredients, in the relative amounts already given. It has been recognized that an effect for yielding the hair appears only when the three ingredients of oestrogens, adrenal hormones and vitamin B2 are respectively in the ranges given and also the quantitative ratio of the oestrogens to the adrenal hormones is as given.

Under such conditions, an effect in generating the hair appears; the maximum effect in yielding hair is seen at the quantitative relationship among the three main ingredients given in embodiments 1 and 2 above.

It is further noted that no inflammation in the skin occurs, because the oestrogens and the adrenal hormones have been made as ultra-low concentrations. Also the liquid does not reach such a quantity as to cause inflammation and to prevent hair generation if it is absorbed and accumulated into the skin.

Thus an agent for yielding hair according to this invention gives a good effect for generating hair but causes no inflammation of the skin. it has been known that vitamin B2 has an action in promoting metabolism of proteins, however, no example using vitamin B2 for yielding hair has been found before. In this invention it has been recognized that vitamin B2 gives a remarkable efficiency for generating the hair as a main ingredient, in the three-ingredient system of oestrogens, adrenal hormones and vitamin B2 Each ingredient other than the main ingredients added in the specific embodiments differs from the main ingredients and shows a specific effect.It is found that chlorophenylamine maleate intensifies the action of adrenal hormones and that pyridoxine hydrochloride, nicotinamide, pantothenyl alcohol, and DL-methionine have effects strengthening the action of vitamin B2 in the metabolism of proteins.

Examples of applying the agent are described below to show its efficiency.

Tests Applied: The tests were carried out by applying the liquid described in embodiment 1 above, once or twice a day with a rate of use of the liquid approximately from 50 to 100 cc a month.

The liquid was applied to 60 persons; hair generation and change in white hair to black were found for all of them. With the young bald-headed, efficiency was recognized in three months, and in addition, hair generation was also found even for a man as old as 75 years. Other examples are given below: (1) A man, 30 years old The liquid, 300 cc, was used for three months, once or twice a day; a bald patch on the left side of the head as large as the palm of a human hand was restored perfectly with the hair given.

(2) A man, 43 years old The liquid, 120 cc, was used for two months, once or twice a day; hair was completely- generated on a bald patch at the front of the head.

(3) A man, 30 years old The liquid, 1 20 cc, was for two months, once a day; a bald patch on the top of the head was restored with the hair generated.

(4) A man, 60 years old The liquid, 200 cc, was used for one and a half months, twice a day; his white and pale hair was changed to black with fresh growth.

Claims

1. A topical agent for generating the hair, comprising oestrogen 0.0033 to 1.0 mg%.

adrenal hormone 0.018 to 2.75 mg% and vitamin B2 0.085 to 25.5 mg% the weight ratio of the oestrogen to the adrenal hormone being 0.01 to 4.0. in water or other medium.

2. An agent for generating the hair substantially as herein described in Example 1 or 2.