JPS6038313A - Hair restorer - Google Patents

Abstract

PURPOSE:To provide a hair restorer containing specific amounts of estrogen, corticosteroid and vitamin B2 at specific weight ratios, capable of exhibiting extremely effective hair restoration activity without causing inflammation of the skin when applied to the head. CONSTITUTION:The objective hair restorer for head is prepared by using (A) 0.0033-1.0mg of an estrogen such as benzoic acid estradiol, (B) 0.018-2.75mg of a corticosteroid such as cortisone acetate (the weight ratio of A/B is 0.01-4.0) and (C) 0.085-25.5mg of vitamin B2 as main components, and dissolving the components homogeneously in 100cc of purified water. Even if the agent is absorbed and accumulated in the skin tissue by the extended use, it does not reach an amount to cause the inflammation of the skin and suppress the restoration of the hair.

Description

[Detailed description of the invention] This invention relates to a hair growth agent that exhibits a hair growth effect.

The typical ingredients of what are generally called hair nourishing agents or hair growth agents are often female hormones or adrenal cortical hormones. Although it has not been proven, it is widely believed that the reason why more men are bald than women is that men tend to have an excess of male hormones, whereas women do not. Based on this relationship, it is clear that the reason many hair products use female hormones is to supplement female hormones to the skin fibers of men, who have an excess of male hormones. Conventionally, female hormones, vitamins (
E or H), alcohol, menthol, etc., or adrenal cortical hormones and vitamins (E or H).
), alcohol, menthol, etc. are known as ingredients. However, the reality is that without exception, they do not have any effect on hair growth, and even those that are called hair growth agents seem to be used by users with high expectations even though they are unable to see any effect. Moreover, the use of inappropriate concentrations of hormones causes inflammation of the skin, and there are many cases in which hair does not grow and even hair is removed due to irritation from the alcohol added.

The present inventor has conducted extensive research into the actual state of the above-mentioned commercially available hair growth agents. Although it is reasonable to use female hormones (follicular hormones) and adrenal cortical hormones in view of their characteristics, there is thought to be room for research into their concentration conditions.

Adrenocortical hormone at a concentration of 0.5% is used for alopecia areata, but there are problems with the concentration when used for a long period of time. Therefore, it is necessary to explore possibilities in the ultra-low concentration range, which have never been attempted before. There is a possibility of using follicular hormone and adrenal cortical hormone in combination and using a special mixing ratio.

In addition, there have been examples of using vitamins as agents for protein metabolism, but it is important to search for a combination that exhibits an appropriate and strong metabolic effect. As a result of studies based on the above ideas, we have completed the present invention.

That is, the present invention provides a hair growth agent that is extremely effective when applied to the human head and has no side effects.

The present invention provides follicle hoA/moy 0.0033 to 0.21
1? .

Adrenocortical hormone 0.018-1.1w9. Vitamin B
, N-made water with 0.085~5.1■ as the main component
Homogeneously dissolved in occ to give an ultra-low concentration, and the weight ratio of follicular hormone to adrenocortical hormone is 0.1 to 0.4.
This is a hair growth agent consisting of a liquid in the following range.

Example 1 of the present invention will be described next. Estradiol benzoate (follicular hormone) 0.00519°, prednisolone acetate (adrenocortical hormone) 0.0275■, phosphate phosphate (vitamin B2) 0.125111g, 7-rabin adenine dinucu V, tf de (vitamin B2) 0.
The main ingredients are chlorpheniramine maleate (antihistamine) 0.075W, pyridoxine hydrochloride (vitamin B.) 0.25W, and nicotinic acid amide 0.025W.
A solution containing 5 wg of alcohol for injection was used, and its purity was about 100%. For example, one ampule of estradiol benzoate contains 0.21 ng of aqueous suspension, but this 1cc solution was homogeneously dissolved in 4 ml of purified water (it is completely dissolved due to its low concentration).
. A specific number of each of the other substances contained in a 2 cc ampoule was homogeneously dissolved in the purified water 41 described above.

Next, as Example 2 of the present invention, 0.0275 cm of cortisone acetate (adrenocortical hormone) was used instead of prednisolone acetate in Example 1, and other substances and amounts were changed from Example 1.
I made it exactly the same.

The configuration, features, and implementation sequence of the present invention have been described above. Apply this to the bald skin of your head. Examples 1 and 2 show the greatest effect among the many examples that have a hair growth effect.

In Examples 1 and 2, the only difference was in the type of adrenal cortical hormone and the other conditions were exactly the same, but it was found that the hair growth effect of both was the same.

As a result of testing under various conditions, Examples 1 and 2 were obtained.
Smell [follicular hormone, adrenal cortex hormone, vitamin B
, plays the role of principal component. To explain the relationship between the degree of absorption of each main component and the hair growth effect, follicular hormone is 0.00% per 100ee.
Hair grows in the concentration range of 0.033 to 0.2■, and adrenal cortical hormone is 0.018 to 1.111 per 1QQcc.
Hair grows within the concentration range of Ig, and vitamin B1 is 100%
Hair growth occurs in the concentration range of 0.085 to 5 IM9 per ee. At the same time, hair grows only when the weight ratio of (follicular hormone)/(adrenocortical hormone) is in the range of 0.1 to 0.4. In other words, follicle hormone, adrenal cortex hormone, vitamin B! It was confirmed that the hair growth effect is exhibited only when the three components are within the above concentration ranges and the quantitative ratio of follicular hormone and adrenal cortical hormone satisfies the above conditions.

Although the hair growth effect appears under these conditions, it has been revealed that the maximum hair growth effect is shown in the quantitative relationship of the main components of Examples 1 and 2.

To explain in more detail the effects of the invention, the ultra-low concentrations of follicular hormones and adrenal cortical hormones not only do not cause skin irritation, but even if this solution is absorbed and accumulated in the skin tissue when applied. The amount does not reach a level that causes inflammation and inhibits hair growth. Moreover, it was confirmed for the first time that a hair growth effect appears at this ultra-low concentration. Adrenal cortical hormone has the effect of enhancing the hair growth effect of follicular hormone, and it was also confirmed for the first time that it exhibits a hair growth effect when the value of the iii ratio of follicular hormone to adrenal cortical hormone is in the range of 0.1 to 0.4. Furthermore, although it has been known for a long time that vitamin B has a protein metabolic effect, there has been no conventional hair growth agent using vitamin B. In the present invention, for the first time, vitamin B has been used and it has been recognized that it exhibits a remarkable hair growth effect as an indispensable component.

Each component other than the main component added in the Examples is different from the indispensable main component and exhibits supporting effects. Chlorpheniramine maleate strengthens the action of adrenal cortical hormones, and pyridoxine hydrochloride, nicotinamide, bantothenyl alcohol, and DL-methionine were found to have the effect of strengthening the protein metabolic action of vitamin B1.

The hair growth agent of the present invention exhibits a hair growth effect of 1-00%, yet does not cause skin irritation. An application example will be described next to further explain the effect.

Application Test The solution described in Example 1 above was applied once or twice a day and tested at a rate of about 50 to 100 el- used per month. The treatment was applied to 60 people, and hair growth and blackening of gray hair were observed in all of them.

It was completely effective in treating premature baldness within three months, and hair growth was also observed in a 75-year-old man. The numerical value is shown below.

(1) A 30-year-old man used 300cc for 3 months, once or twice a day, and the bald area on the left side of his head was completely regrown.

(2143-year-old man, 120 yen (c) used for 2 months, once or twice a day, the bald area on the front of his head has completely grown back.

(A 37-year-old man used 120 ec for 2 months, once a day, and the bald area on the top of his head completely grew back.)

(4) 60-year-old man, using 200cc for 1.5 months, 1
Twice a day, gray hair and thinning hair turn black and grow back.

Procedural amendment September 9, 1980 Kazuo Wakasugi, Commissioner of the Patent Office1, Indication of the case 1982 Patent Application No. 1.457082, Name of the invention Hair growth agent 3, Person making the amendment Case and Relationship: Patent applicant I1mi Address: 574-64 Kazawatono, Omiya City, Saitama Prefecture;
Agent Address: 4-183-5 Sakae, Ina-cho, Kitaadachi-gun, Saitama Prefecture Description (as amended in full text) 1. Title of the invention: Hair growth agent 2. Claims: Follicular hormone 0.0033-1. Omg, adrenal cortical hormone 0.018-2.75■, vitamin B20085
~25.5■ as a main component, homogeneously dissolved in 100Ω of purified water, and having a weight ratio of (follicular hormone)/(adrenocortical hormone) in the range of 0.01 to 4.0. A hair growth agent characterized by:

3. Detailed Description of the Invention The present invention relates to a hair growth agent that exhibits an extremely effective hair growth effect when applied to the human head.

The typical ingredients of what are generally called hair tonics or hair growth agents are often female hormones or adrenal cortical hormones. It is widely believed, although not proven, that the reason why more men are bald than women is that men tend to have an excess of male hormones, while women do not. Based on this relationship, it is clear that the reason why female hormones are often used in hair tonics and hair growth agents is to supplement female hormones to men's skin tissue, which has an excess of male hormones. Conventionally, there have been known products that contain female hormones, vitamins (E or H), alcohol, menthol, etc., or those that contain adrenal cortical hormones and vitamins (E or H), alcohol, menthol, etc. It is being However, the reality is that without exception, they do not have any effect on hair growth, and it seems that even the so-called hair-growth agents are used by users with high expectations even though they are unable to see any effect. Moreover, the use of inappropriate concentrations of hormones can cause skin irritation.
There are many cases in which not only hair does not grow but also hair is removed due to the stimulation of the alcohol added.

The present inventor conducted repeated research in view of the actual situation of the above-mentioned commercially available hair growth agents. Although it is reasonable to use female hormones (follicular hormones) and adrenal cortical hormones in view of their characteristics, there is thought to be room for research into their concentration conditions.

Adrenocortical hormone at a concentration of 0.5% is used for alopecia areata, but there are problems with the concentration when used for a long period of time. Therefore, it is necessary to explore possibilities in the ultra-low concentration range, which have never been attempted before. Although there is no example yet of using follicular hormone and adrenal cortical hormone in combination, it is possible to use them together and at a specific mixing ratio. In addition, there have been examples of using vitamins as agents for protein metabolism, but it is important to search for a combination that exhibits an appropriate and strong metabolic effect.

As a result of studies based on the above ideas, we have completed the present invention.

That is, the present invention provides a hair growth agent that is extremely effective when applied to the human head and has no side effects.

This defense is that follicle hormone 0.0033-1.0Tng,
Adrenal cortical hormone 0.018-2.75■, vitamin B
Purified water 100% containing 20.085~25.5cm as the main component
This is a hair growth agent consisting of a liquid homogeneously dissolved in CC to obtain an extremely low concentration and having a weight ratio of follicular hormone to adrenal cortical hormone in the range of 0.01 to 4.0.

Example 1 of the present invention will be described next. Estradiol benzoate (follicular hormone) 0.005■, prednisolone acetate (adrenocortical hormone) 0.0275■, riboflavin phosphate (vitamin B2) 0.125ml, flavin adenine dinucleotide (vitamin B2) 0.0
The main ingredients are chlorpheniramine maleate (antihistamine) 0.075■, pyridoxine hydrochloride (
Vitamin B6) 0.25■, Nicotinic acid amide 0.5■
, 0.25 μm of bantothenyl alcohol, and 1 μm of DL-methionine were homogeneously dispersed in 100 cc of purified water. To prepare this solution, each of these substances was used in ampoules for injection, and the purity thereof was approximately 100%. For example, estradiol benzoate is an aqueous suspension in ampoules, ICr.
This 1 Cr solution was homogeneously dissolved in 4 tons of purified water (completely dissolved since the concentration is low).

A specific number of mg of each of the other substances contained in a 2 cr ampoule was homogeneously dissolved in 4 tons of the purified water.

Next, as Example 2 of the present invention, 0.0275 cm of cortisone acetate (adrenocortical hormone) was used instead of prednisolone acetate in Example 1, and other substances and amounts were changed from Example 1.
I made it exactly the same.

The configuration, features, and embodiments of the present invention have been described above. Apply this to the bald skin of your head. Examples 1 and 2 exhibit the greatest effect among the many examples that have a hair growth effect.

In Examples 1 and 2, the only difference was in the type of adrenal cortical hormone and other conditions were exactly the same, but it was found that the hair growth effect of both was the same.

As a result of testing under various conditions, Examples 1 and 2 were obtained.
Follicle hormone, adrenal cortical hormone, vitamin B
2 plays the role of the principal component. Explaining the relationship between the concentration of each main component and the hair growth effect, follicular hormone produces hair in a concentration range of 0.0033 to 1.0 per 00 ω, and adrenal cortical hormone has a concentration of 0.018 to 2.75 per 100 cc.
Hair grows in the concentration range of ■, and vitamin B2 is ]0Oc
Hair growth occurs in a concentration range of 0.085 to 25.5 mg per c. At the same time, hair grows only when the weight ratio of (follicular hormone)/(adrenocortical hormone) is in the range of 0.01 to 40. In other words, the hair growth effect is produced only when the three components of follicular hormone, adrenal cortical hormone, and vitamin B2 are each in the above-mentioned concentration range, and the quantitative ratio of follicular hormone and adrenal cortical hormone satisfies the above-mentioned conditions. I admitted that I did it.

Although the hair growth effect appears under these conditions, it has been revealed that the maximum hair growth effect is shown in the quantitative relationship of the main components of Examples 1 and 2.

To explain the effects of the present invention in more detail, the ultra-low concentrations of follicular hormones and adrenal cortical hormones not only do not cause skin inflammation, but even if this liquid is applied and absorbed and accumulated in the skin tissue. The amount does not reach a level that causes inflammation and inhibits hair growth. Moreover, it was confirmed for the first time that a hair growth effect appears at this ultra-low concentration. Adrenal cortical hormone has the effect of enhancing the hair growth effect of follicular hormone, and it was also confirmed for the first time that the hair growth effect is shown when the weight ratio of follicular hormone to adrenal cortical hormone is in the range of 001 to 4.0. Furthermore, it has been known for a long time that vitamin B2 has a protein metabolic effect, and there is no prior example of using vitamin B2 in a hair growth agent. In the present invention, we used vitamin B2 for the first time, and found that a three-component system of follicular hormone, adrenal cortical hormone, and vitamin B2 as essential main components exhibits a remarkable hair growth effect.

Each component other than the main component added in the Examples is different from the indispensable main component and exhibits supporting effects. It was recognized that chlorpheniramine maleate strengthens the action of adrenal cortical hormones, and that pyridoxine hydrochloride, nicotinamide, bantothenyl alcohol, and DL-methionine all have the effect of strengthening the protein metabolic action of vitamin B2.

The hair growth agent of the present invention exhibits 100% hair growth effect, yet does not cause skin irritation. An application example will be described next to further explain the effect.

Application Test The solution described in Example 1 above was applied once or twice a day and tested at a rate of about 50-100 CC per month. The treatment was applied to 60 people, and hair growth and blackening of gray hair were observed in all of them.

It was completely effective in treating young baldness after 3 months, and hair growth was also observed in a 75-year-old man. Here are some examples:

(1) A 30-year-old man, number 3, uses 300cc per month, once or twice a day, and the bald patch on the left side of his head the size of his palm has completely grown back.

(2) A 43-year-old man used 120CC for 2 months, once or twice a day, and the bald area on the front of his head was completely regrown.

(3) A 30-year-old man used 1200c for 2 months, once a day, and the bald area on the top of his head completely grew back.

(4) A 60-year-old man used 200σ for 1.5 months, twice a day, and his gray and thinning hair turned black and grew back.

Claims (1)

[Claims] Follicular hormone 0.0033-0.2■, adrenal cortical hormone 0.018-1.1■, vitamin B. Purified water with 0.085-5.111P as the main component 100
A hair growth agent characterized by comprising a liquid homogeneously dissolved in cC and having a weight ratio of (follicular hormone)/(adrenocortical hormone) in the range of 0.1 to 0.4.