GB2134786A - Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same - Google Patents

Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same

Info

Publication number
GB2134786A
GB2134786A GB08406704A GB8406704A GB2134786A GB 2134786 A GB2134786 A GB 2134786A GB 08406704 A GB08406704 A GB 08406704A GB 8406704 A GB8406704 A GB 8406704A GB 2134786 A GB2134786 A GB 2134786A
Authority
GB
United Kingdom
Prior art keywords
caffeine
analgesic
methods
same
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08406704A
Other versions
GB8406704D0 (en
GB2134786B (en
Inventor
Abraham Sunshine
Eugene M Laska
Carole E Siegel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Vicks Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Vicks Inc filed Critical Richardson Vicks Inc
Publication of GB8406704D0 publication Critical patent/GB8406704D0/en
Publication of GB2134786A publication Critical patent/GB2134786A/en
Application granted granted Critical
Publication of GB2134786B publication Critical patent/GB2134786B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel analgesic and anti-inflammatory compositions of matter for use in eliciting an analgesic or anti-inflammatory response, said compositions comprising caffeine together with a selected non-narcotic analgesic/nonsteroidal anti-inflammatory drug or a selected narcotic analgesic, or both. When used in combination with the selected drugs, caffeine enhances the analgesic or anti-inflammatory response and also hastens its onset.
GB08406704A 1982-07-22 1983-07-21 Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same Expired GB2134786B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40059782A 1982-07-22 1982-07-22
PCT/US1983/001121 WO1984000488A1 (en) 1982-07-22 1983-07-21 Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same

Publications (3)

Publication Number Publication Date
GB8406704D0 GB8406704D0 (en) 1984-04-18
GB2134786A true GB2134786A (en) 1984-08-22
GB2134786B GB2134786B (en) 1986-05-08

Family

ID=23584242

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08406704A Expired GB2134786B (en) 1982-07-22 1983-07-21 Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same

Country Status (15)

Country Link
JP (3) JPS59501459A (en)
AT (2) AT389226B (en)
AU (1) AU558485B2 (en)
BE (1) BE897356A (en)
CA (1) CA1217429A (en)
CH (1) CH659391A5 (en)
DE (1) DE3390116C2 (en)
FR (1) FR2530469A1 (en)
GB (1) GB2134786B (en)
IE (1) IE55367B1 (en)
IT (1) IT1206502B (en)
NL (1) NL191432C (en)
SE (1) SE466481B (en)
WO (1) WO1984000488A1 (en)
ZA (2) ZA835326B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559343A (en) * 1982-09-07 1985-12-17 Alcon Laboratories, Inc. Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therapeutic agents
US4567183A (en) * 1983-03-11 1986-01-28 Analgesic Associates Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4558051A (en) * 1983-10-11 1985-12-10 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
CH664085A5 (en) * 1985-02-08 1988-02-15 Ciba Geigy Ag PHARMACEUTICAL PREPARATIONS WITH ANALGETIC EFFECTIVENESS AND THEIR PRODUCTION.
CH669523A5 (en) * 1986-06-25 1989-03-31 Mepha Ag
GB8626098D0 (en) * 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
US20040115290A1 (en) 2001-06-20 2004-06-17 Tripp Matthew L. Modulation of inflammation by hops fractions and derivatives
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
CN1268338C (en) 2001-07-06 2006-08-09 恩德制药公司 Oral administration of 6-hydroxy-oxymorphone for use as antalgesic
US8158160B2 (en) 2001-11-13 2012-04-17 Eric Hauser Kuhrts Anti-inflammatory cyclooxygenase inhibitors
US7914831B2 (en) * 2004-02-27 2011-03-29 Metaproteomics, Llc Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines
JP2006282644A (en) * 2005-04-05 2006-10-19 Idemitsu Kosan Co Ltd Fatigue recovery agent
TW201247195A (en) * 2011-04-28 2012-12-01 Kowa Co Stable pharmaceutical composition
JP2018076305A (en) * 2016-10-31 2018-05-17 エスエス製薬株式会社 Pharmaceutical composition
JP6811453B1 (en) * 2020-06-24 2021-01-13 医療法人すぎやま内科 Composition for transdermal absorption

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3439094A (en) * 1967-07-20 1969-04-15 Warner Lambert Pharmaceutical Analgesic compositions containing namol xenyrate,caffeine and acetyl-rho-aminophenol
US4049803A (en) * 1976-04-26 1977-09-20 Bristol-Myers Company Augmentation of blood levels of aspirin
JPS5423132A (en) * 1977-07-19 1979-02-21 Dai Ichi Seiyaku Co Ltd Analgesic composition
JPS54154416A (en) * 1978-05-26 1979-12-05 Tdk Electronics Co Ltd High dielectric constant porcelain composition
US4233316A (en) * 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4233315A (en) * 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4234601A (en) * 1978-12-18 1980-11-18 Mcneilab, Inc. Analgesic potentiation
US4233314A (en) * 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4233317A (en) * 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4237140A (en) * 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4315936A (en) * 1979-12-17 1982-02-16 Ortho Pharmaceutical Corporation Analgesic composition
JPS56154416A (en) * 1980-04-30 1981-11-30 Kaken Pharmaceut Co Ltd Antipyretic analgesic composition
US4322427A (en) * 1981-04-16 1982-03-30 Bristol-Myers Company Analgetic compositions and methods of use
US4420483A (en) * 1982-07-22 1983-12-13 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising ibuprofen and methods of using same

Also Published As

Publication number Publication date
IE831715L (en) 1984-01-22
IT8322173A0 (en) 1983-07-21
JPS59501459A (en) 1984-08-16
FR2530469A1 (en) 1984-01-27
JPS59501460A (en) 1984-08-16
CA1217429A (en) 1987-02-03
ATA903983A (en) 1989-04-15
NL191432B (en) 1995-03-01
ZA835324B (en) 1984-09-26
CH659391A5 (en) 1987-01-30
NL8320240A (en) 1984-06-01
ATA245988A (en) 1989-08-15
JPH07165583A (en) 1995-06-27
SE8401538D0 (en) 1984-03-20
AU558485B2 (en) 1987-01-29
AT389998B (en) 1990-02-26
ZA835326B (en) 1984-09-26
DE3390116C2 (en) 1994-06-16
SE466481B (en) 1992-02-24
IT1206502B (en) 1989-04-27
SE8401538L (en) 1984-03-20
AT389226B (en) 1989-11-10
NL191432C (en) 1995-07-04
AU1881683A (en) 1984-02-23
BE897356A (en) 1983-11-14
GB8406704D0 (en) 1984-04-18
WO1984000488A1 (en) 1984-02-16
IE55367B1 (en) 1990-08-29
DE3390116T1 (en) 1985-01-10
GB2134786B (en) 1986-05-08

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20030720