GB2118550B - Process for preparing substitued 2-amiobenzimidazoles - Google Patents

Process for preparing substitued 2-amiobenzimidazoles

Info

Publication number
GB2118550B
GB2118550B GB08309387A GB8309387A GB2118550B GB 2118550 B GB2118550 B GB 2118550B GB 08309387 A GB08309387 A GB 08309387A GB 8309387 A GB8309387 A GB 8309387A GB 2118550 B GB2118550 B GB 2118550B
Authority
GB
United Kingdom
Prior art keywords
preparing
amiobenzimidazoles
substitued
amino
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08309387A
Other languages
English (en)
Other versions
GB2118550A (en
Inventor
James Howard Wikel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB2118550A publication Critical patent/GB2118550A/en
Application granted granted Critical
Publication of GB2118550B publication Critical patent/GB2118550B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
GB08309387A 1982-04-08 1983-04-07 Process for preparing substitued 2-amiobenzimidazoles Expired GB2118550B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/366,883 US4434288A (en) 1982-04-08 1982-04-08 Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles

Publications (2)

Publication Number Publication Date
GB2118550A GB2118550A (en) 1983-11-02
GB2118550B true GB2118550B (en) 1985-08-29

Family

ID=23444984

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08309387A Expired GB2118550B (en) 1982-04-08 1983-04-07 Process for preparing substitued 2-amiobenzimidazoles

Country Status (21)

Country Link
US (1) US4434288A (OSRAM)
EP (1) EP0091794B1 (OSRAM)
JP (1) JPS58188866A (OSRAM)
KR (1) KR860001582B1 (OSRAM)
AT (1) ATE38986T1 (OSRAM)
CA (1) CA1187874A (OSRAM)
CS (2) CS127784A2 (OSRAM)
DD (1) DD209623A5 (OSRAM)
DE (1) DE3378578D1 (OSRAM)
DK (1) DK152983A (OSRAM)
ES (1) ES521319A0 (OSRAM)
FI (1) FI831192A7 (OSRAM)
GB (1) GB2118550B (OSRAM)
GR (1) GR78170B (OSRAM)
HU (1) HU193501B (OSRAM)
IE (1) IE54836B1 (OSRAM)
IL (1) IL68298A (OSRAM)
PL (1) PL241386A1 (OSRAM)
PT (1) PT76500B (OSRAM)
RO (1) RO86853B (OSRAM)
SU (1) SU1189338A3 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435418A (en) * 1982-12-13 1984-03-06 Smithkline Beckman Corporation 5-Phenylethenylbenzimidazoles
JPS62221672A (ja) * 1986-03-20 1987-09-29 Nippon Tokushu Noyaku Seizo Kk 新規スルホニルアゾ−ル
US5545653A (en) * 1995-06-07 1996-08-13 Eli Lilly And Company Anti-viral compounds
US5693661A (en) * 1995-06-07 1997-12-02 Eli Lilly And Company Anti-viral compounds
CN1220601A (zh) * 1996-06-05 1999-06-23 伊莱利利公司 抗病毒化合物
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
ATE238998T1 (de) 1997-02-25 2003-05-15 Us Gov Health & Human Serv Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore
EP1001767A4 (en) * 1997-06-04 2001-07-04 Lilly Co Eli ANTIVIRAL CONNECTIONS
US10292390B2 (en) 2011-11-04 2019-05-21 Wisconsin Alumni Research Foundation Inhibition and dispersion of bacterial biofilms with 2-aminobenzimidazole derivatives
CN108997158B (zh) * 2018-07-16 2020-12-15 青岛科技大学 一种实现二取代酰胺与二苯基甲酮偶联的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3825537A (en) 1972-02-28 1974-07-23 Squibb & Sons Inc 1-thiazolin-2-yl(or thiazin-2-yl)-2-aminobenzimidazoles and derivatives thereof
US4243813A (en) * 1974-07-01 1981-01-06 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles
US4196125A (en) 1974-07-01 1980-04-01 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles
US4018790A (en) 1975-05-08 1977-04-19 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles
PT65486B (en) * 1975-08-28 1978-03-24 Lilly Co Eli Process for the preparation of carbonil-substituted 1-sulfonylbenzimidazoles
US4174454A (en) 1975-08-28 1979-11-13 Eli Lilly And Company Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles
CA1076582A (en) 1975-10-28 1980-04-29 Charles J. Paget Antiviral thiazolinyl or thiazinyl ketobenzimidazoles
US4008243A (en) 1975-11-19 1977-02-15 Eli Lilly And Company Antiviral thiazolinyl or thiazinyl benzimidazole esters
US4118573A (en) 1975-11-24 1978-10-03 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles
US4230868A (en) 1979-04-17 1980-10-28 Eli Lilly And Company α-Alkyl-α-hydroxybenzyl-substituted 1-sulfonylbenzimidazoles

Also Published As

Publication number Publication date
FI831192A0 (fi) 1983-04-08
RO86853B (ro) 1985-05-31
SU1189338A3 (ru) 1985-10-30
CS127784A2 (cs) 1984-12-14
KR840004411A (ko) 1984-10-15
DD209623A5 (de) 1984-05-16
IE54836B1 (en) 1990-02-28
IL68298A (en) 1986-09-30
JPS58188866A (ja) 1983-11-04
DK152983D0 (da) 1983-04-06
KR860001582B1 (ko) 1986-10-10
ATE38986T1 (de) 1988-12-15
GR78170B (OSRAM) 1984-09-26
PL241386A1 (en) 1983-11-21
FI831192L (fi) 1983-10-09
EP0091794A1 (en) 1983-10-19
DE3378578D1 (en) 1989-01-05
ES8405376A1 (es) 1984-06-01
US4434288A (en) 1984-02-28
GB2118550A (en) 1983-11-02
ES521319A0 (es) 1984-06-01
CS253983A2 (en) 1984-12-14
EP0091794B1 (en) 1988-11-30
CA1187874A (en) 1985-05-28
RO86853A (ro) 1985-05-20
DK152983A (da) 1983-10-09
IE830795L (en) 1983-10-08
FI831192A7 (fi) 1983-10-09
HU193501B (en) 1987-10-28
PT76500A (en) 1983-05-01
PT76500B (en) 1986-02-06

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee