GB2111050B - N-substituted-2-pyridylindoles - Google Patents

N-substituted-2-pyridylindoles

Info

Publication number
GB2111050B
GB2111050B GB08232457A GB8232457A GB2111050B GB 2111050 B GB2111050 B GB 2111050B GB 08232457 A GB08232457 A GB 08232457A GB 8232457 A GB8232457 A GB 8232457A GB 2111050 B GB2111050 B GB 2111050B
Authority
GB
United Kingdom
Prior art keywords
pyridylindoles
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08232457A
Other languages
English (en)
Other versions
GB2111050A (en
Inventor
Harris Burt Renfroe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB2111050A publication Critical patent/GB2111050A/en
Application granted granted Critical
Publication of GB2111050B publication Critical patent/GB2111050B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
GB08232457A 1981-11-19 1982-11-12 N-substituted-2-pyridylindoles Expired GB2111050B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32301881A 1981-11-19 1981-11-19

Publications (2)

Publication Number Publication Date
GB2111050A GB2111050A (en) 1983-06-29
GB2111050B true GB2111050B (en) 1985-09-11

Family

ID=23257445

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08232457A Expired GB2111050B (en) 1981-11-19 1982-11-12 N-substituted-2-pyridylindoles

Country Status (22)

Country Link
EP (1) EP0080154B1 (enExample)
JP (1) JPS5892677A (enExample)
KR (1) KR880002010B1 (enExample)
AR (3) AR241428A1 (enExample)
AT (1) ATE15196T1 (enExample)
AU (1) AU564233B2 (enExample)
CA (1) CA1197249A (enExample)
DD (1) DD204924A5 (enExample)
DE (1) DE3265892D1 (enExample)
DK (1) DK169104B1 (enExample)
ES (4) ES8501755A1 (enExample)
FI (1) FI75344C (enExample)
GB (1) GB2111050B (enExample)
GR (1) GR77035B (enExample)
HU (1) HU190425B (enExample)
IE (1) IE54156B1 (enExample)
IL (1) IL67284A (enExample)
NO (1) NO159929C (enExample)
NZ (1) NZ202551A (enExample)
PH (1) PH19212A (enExample)
PT (1) PT75870B (enExample)
ZA (1) ZA828505B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
GB8626297D0 (en) * 1986-11-04 1986-12-03 Ici Plc Pharmaceutical compositions
GB8626296D0 (en) * 1986-11-04 1986-12-03 Ici Plc Therapeutic agents
GB9319100D0 (en) * 1993-09-15 1993-11-03 Pfizer Ltd 3-(3-pyridinyl)h-indoles
CA2140722A1 (en) * 1994-01-24 1995-07-25 Joseph A. Jakubowski Beta-carboline thromboxane synthase inhibitors
US6828344B1 (en) * 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
GB0307891D0 (en) * 2003-04-04 2003-05-14 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
US12030878B2 (en) * 2017-12-15 2024-07-09 Bristol-Myers Squibb Company Substituted indole ether compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468894A (en) * 1966-11-29 1969-09-23 Geigy Chem Corp Certain 2-pyridyl-substituted indole derivatives
DE2909779A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue indolderivate, deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
ES8602750A1 (es) 1985-12-01
NO823869L (no) 1983-05-20
DE3265892D1 (en) 1985-10-03
PT75870A (en) 1982-12-01
ES530128A0 (es) 1985-12-01
IL67284A (en) 1986-03-31
AU9067582A (en) 1983-05-26
ES8601962A1 (es) 1985-11-16
KR880002010B1 (ko) 1988-10-12
AR243519A1 (es) 1993-08-31
EP0080154A3 (en) 1983-09-28
ES530126A0 (es) 1985-11-16
AR241428A1 (es) 1992-07-31
EP0080154B1 (de) 1985-08-28
FI823938A0 (fi) 1982-11-17
AU564233B2 (en) 1987-08-06
DD204924A5 (de) 1983-12-14
GB2111050A (en) 1983-06-29
EP0080154A2 (de) 1983-06-01
DK514182A (da) 1983-05-20
KR840002368A (ko) 1984-06-25
NO159929C (no) 1989-02-22
ATE15196T1 (de) 1985-09-15
ES530127A0 (es) 1986-06-16
FI75344B (fi) 1988-02-29
FI823938L (fi) 1983-05-20
ES517439A0 (es) 1984-12-01
NZ202551A (en) 1985-11-08
FI75344C (fi) 1988-06-09
PH19212A (en) 1986-02-04
ES8608508A1 (es) 1986-06-16
AR243177A1 (es) 1993-07-30
HU190425B (en) 1986-09-29
NO159929B (no) 1988-11-14
JPS5892677A (ja) 1983-06-02
PT75870B (en) 1986-01-21
GR77035B (enExample) 1984-09-04
ZA828505B (en) 1983-09-28
CA1197249A (en) 1985-11-26
DK169104B1 (da) 1994-08-15
IE54156B1 (en) 1989-07-05
JPH029031B2 (enExample) 1990-02-28
ES8501755A1 (es) 1984-12-01

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19981112