GB2104081B - Production of plasminogen activator - Google Patents

Production of plasminogen activator

Info

Publication number
GB2104081B
GB2104081B GB08219498A GB8219498A GB2104081B GB 2104081 B GB2104081 B GB 2104081B GB 08219498 A GB08219498 A GB 08219498A GB 8219498 A GB8219498 A GB 8219498A GB 2104081 B GB2104081 B GB 2104081B
Authority
GB
United Kingdom
Prior art keywords
production
plasminogen activator
plasminogen
activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08219498A
Other languages
English (en)
Other versions
GB2104081A (en
Inventor
Avinoam Kadouri
Zvi Bohak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of GB2104081A publication Critical patent/GB2104081A/en
Application granted granted Critical
Publication of GB2104081B publication Critical patent/GB2104081B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB08219498A 1981-07-15 1982-07-06 Production of plasminogen activator Expired GB2104081B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL63317A IL63317A (en) 1981-07-15 1981-07-15 Production of plasminogen activator

Publications (2)

Publication Number Publication Date
GB2104081A GB2104081A (en) 1983-03-02
GB2104081B true GB2104081B (en) 1985-06-12

Family

ID=11052764

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08219498A Expired GB2104081B (en) 1981-07-15 1982-07-06 Production of plasminogen activator

Country Status (6)

Country Link
JP (1) JPS5865219A (ja)
DE (1) DE3226320A1 (ja)
FR (1) FR2510604B1 (ja)
GB (1) GB2104081B (ja)
IL (1) IL63317A (ja)
IT (1) IT1195939B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60158115A (ja) * 1984-01-30 1985-08-19 Meiji Milk Prod Co Ltd プラズミノーゲンアクチベーターの製造法
JPS60259187A (ja) * 1984-04-19 1985-12-21 マイルス・ラボラトリ−ス・インコ−ポレ−テツド プラスミノーゲン活性化因子を増収する方法
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
DE3479814D1 (en) * 1984-06-05 1989-10-26 Asahi Chemical Ind Process for the preparation of a plasminogen activator
US5210037A (en) * 1988-03-22 1993-05-11 Centocor Incorporated Method to enhance TPA production
AU3364589A (en) * 1988-03-22 1989-10-16 Invitron Corporation Method to enhance tpa production
DE4128953A1 (de) * 1991-08-30 1993-03-04 Basf Ag Verfahren zur kultivierung von saeugerzellen im fliessbettreaktor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
JPS55144887A (en) * 1979-04-26 1980-11-12 Asahi Chem Ind Co Ltd Preparation of physiologically active substance

Also Published As

Publication number Publication date
IL63317A0 (en) 1981-10-30
FR2510604A1 (fr) 1983-02-04
DE3226320C2 (ja) 1989-08-17
FR2510604B1 (fr) 1985-07-12
JPS5865219A (ja) 1983-04-18
DE3226320A1 (de) 1983-02-10
GB2104081A (en) 1983-03-02
IT8222392A0 (it) 1982-07-14
IL63317A (en) 1985-05-31
JPH0137115B2 (ja) 1989-08-04
IT1195939B (it) 1988-11-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee