GB210050A - Process for the preparation of synthetic d-ªÎ and l-ªÎ-cocaine - Google Patents
Process for the preparation of synthetic d-ªÎ and l-ªÎ-cocaineInfo
- Publication number
- GB210050A GB210050A GB30087/23A GB3008723A GB210050A GB 210050 A GB210050 A GB 210050A GB 30087/23 A GB30087/23 A GB 30087/23A GB 3008723 A GB3008723 A GB 3008723A GB 210050 A GB210050 A GB 210050A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ecgonine
- bromcamphor
- salt
- methyl ester
- cocaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
d- and l-q -Cocaines are prepared by resolving dl-q - ecgonine methyl ester into its optical antipodes and benzoylating them. According to examples, the l-q -ecgonine methyl ester is obtained from the racemate in the form of its salt with d-a -bromcamphor-b -sulphonic acid, and the d-q -ecgonine methylester as its salt either with d-a -bromcamphor-p -sulphonic acid or with natural l-malic acid; the l-malate of the d-q -ester is also described: the benzoylation is effected with benzoic anhydride in benzene solution; the optical properties of both free alkaloids and their hydrochlorides and of the q -ecgonine esters are given.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE210050X | 1923-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB210050A true GB210050A (en) | 1924-04-24 |
Family
ID=5795309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30087/23A Expired GB210050A (en) | 1923-01-17 | 1923-11-29 | Process for the preparation of synthetic d-ªÎ and l-ªÎ-cocaine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB210050A (en) |
-
1923
- 1923-11-29 GB GB30087/23A patent/GB210050A/en not_active Expired
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