GB2089209A - Contraceptive treatment of male mammals - Google Patents

Contraceptive treatment of male mammals

Info

Publication number
GB2089209A
GB2089209A GB8201856A GB8201856A GB2089209A GB 2089209 A GB2089209 A GB 2089209A GB 8201856 A GB8201856 A GB 8201856A GB 8201856 A GB8201856 A GB 8201856A GB 2089209 A GB2089209 A GB 2089209A
Authority
GB
United Kingdom
Prior art keywords
phe
group
peptides
pro
lrf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB8201856A
Other versions
GB2089209B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of GB2089209A publication Critical patent/GB2089209A/en
Application granted granted Critical
Publication of GB2089209B publication Critical patent/GB2089209B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Peptides which are LRF analogs that inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads can be effective contraceptives when administered to male mammals. The peptides are LRF antagonists having a binding affinity at least about 15 times that exhibited by LRF and which have an ICR<u50>u of less than 1/1. Examples of peptides which may be used are those having the structure: R<u1>u-R<u2>u-R<u3>u-D-Trp-Ser-Tyr-R<u4>u-Leu-Arg-Pro-Gly-NH<u2>u wherein R<u1>u is selected from the group consisting of hydrogen, formyl, acetyl, acrylyl, benzoyl and allyl; R<u2>u is selected from the group consisting of dehydro Pro, dehydro D-Pro, Thz and D-Thz; R<u3>u is selected from the group consisting of pCl-D-Phe, pF-D-Phe, pNO<u2>u-D-Phe and 3, 4 Cl-D-Phe; R<u4>u is selected from the group consisting of D-Trp and (imBzl) D-His; and Leu may be substituted by N<s//c>sMeLeu.
GB8201856A 1980-06-26 1980-06-26 Contraceptive treatment of male mammals Expired GB2089209B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1980/000818 WO1982000004A1 (en) 1980-06-26 1980-06-26 Contraceptive treatment of male mammals

Publications (2)

Publication Number Publication Date
GB2089209A true GB2089209A (en) 1982-06-23
GB2089209B GB2089209B (en) 1984-09-05

Family

ID=22154416

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8201856A Expired GB2089209B (en) 1980-06-26 1980-06-26 Contraceptive treatment of male mammals

Country Status (6)

Country Link
BE (1) BE889388A (en)
GB (1) GB2089209B (en)
NZ (1) NZ197464A (en)
PH (1) PH16650A (en)
WO (1) WO1982000004A1 (en)
ZA (1) ZA814141B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835108A (en) * 1972-02-15 1974-09-10 American Home Prod Process for preparing the releasing hormone of luteinizing hormone(lh)and of follicle stimulating hormone(fsh),salts and compositions thereof,and intermediates therefor
CA1009230A (en) * 1972-09-26 1977-04-26 Daiichi Seiyaku Co. Peptides effecting to the release of sex hormones and a method for preparing the same
US4002738A (en) * 1975-05-30 1977-01-11 Abbott Laboratories Treatment of specified neoplasias
US4005194A (en) * 1975-06-23 1977-01-25 Abbott Laboratories Treatment of prostatic hyperplasia
US4071622A (en) * 1976-02-11 1978-01-31 Abbott Laboratories Treatment of a mammary or DMBA inducible tumor
US4218439A (en) * 1977-07-14 1980-08-19 The Salk Institute For Biological Studies Peptide which inhibits gonadal function
US4244946A (en) * 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone

Also Published As

Publication number Publication date
PH16650A (en) 1983-12-06
GB2089209B (en) 1984-09-05
ZA814141B (en) 1982-07-28
WO1982000004A1 (en) 1982-01-07
BE889388A (en) 1981-10-16
NZ197464A (en) 1985-09-13

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee