GB2009182A - Peptides which inhibit gonadal function - Google Patents

Peptides which inhibit gonadal function

Info

Publication number
GB2009182A
GB2009182A GB7846680A GB7846680A GB2009182A GB 2009182 A GB2009182 A GB 2009182A GB 7846680 A GB7846680 A GB 7846680A GB 7846680 A GB7846680 A GB 7846680A GB 2009182 A GB2009182 A GB 2009182A
Authority
GB
United Kingdom
Prior art keywords
peptides
pro
trp
phe
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7846680A
Other versions
GB2009182B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/950,301 external-priority patent/US4215038A/en
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of GB2009182A publication Critical patent/GB2009182A/en
Application granted granted Critical
Publication of GB2009182B publication Critical patent/GB2009182B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads having the structure: R1-R2-R3-Ser-Tyr-R4-R5-Arg-R6 wherein R1 is D-pGlu, D-Pro, D-Trp, D- His, D-Arg, D-Leu, formyl D-Pro, acetyl D-Pro, benzoyl D-Pro or beta -Ala; R2 is D- Phe, Phe, N alpha Me-Phe, His, D-His, D- Trp, Trp or N alpha Me-Leu, R3 is D-Trp, Trp, D-Phe, Phe, Pro or D-His; R4 is Gly, D-Trp, D-Phe or D-Tyr; R5 is Leu or N alpha Me-Leu; and R6 is Pro-Gly-NH2 or Pro-NH-CH2-CH3. Intermediates for said peptides, a solid phase technique for preparing said peptides, formulations comprising said peptides and the use of said peptides in inhibiting steroidal release from the gonads and in preventing ovulation in females and/or in the resorption of recently-fertilized ova are also described.
GB7846680A 1977-11-30 1978-11-30 Peptides which inhibit gonadal function Expired GB2009182B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85583777A 1977-11-30 1977-11-30
US05/950,301 US4215038A (en) 1978-10-16 1978-10-16 Peptides which inhibit gonadal function

Publications (2)

Publication Number Publication Date
GB2009182A true GB2009182A (en) 1979-06-13
GB2009182B GB2009182B (en) 1982-02-24

Family

ID=27127312

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7846680A Expired GB2009182B (en) 1977-11-30 1978-11-30 Peptides which inhibit gonadal function

Country Status (9)

Country Link
AU (1) AU520419B2 (en)
CA (1) CA1116594A (en)
CH (1) CH639942A5 (en)
DE (1) DE2851630A1 (en)
FR (1) FR2410642A1 (en)
GB (1) GB2009182B (en)
NL (1) NL7811723A (en)
NZ (1) NZ188987A (en)
SE (1) SE444946B (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038135A2 (en) * 1980-04-15 1981-10-21 The Salk Institute For Biological Studies LRF antagonists
EP0041286A1 (en) * 1980-06-02 1981-12-09 Andrew Victor Schally LH-RH antagonists
JPS5735550A (en) * 1980-04-15 1982-02-26 Salk Inst For Biological Studi Improved lrf antagonist
EP0063423A1 (en) * 1981-04-21 1982-10-27 The Salk Institute For Biological Studies GnRH antagonists
EP0122712A2 (en) * 1983-03-10 1984-10-24 The Salk Institute For Biological Studies GnRH antagonists
EP0162575A2 (en) * 1984-05-21 1985-11-27 The Salk Institute For Biological Studies GnRH Antagonists VII
EP0171477A2 (en) * 1984-06-18 1986-02-19 The Administrators Of The Tulane University Educational Fund Amino acid-containing therapeutic compounds
EP0197798A2 (en) * 1985-04-09 1986-10-15 The Administrators Of The Tulane University Educational Fund Peptides
EP0225746A2 (en) * 1985-11-14 1987-06-16 The Administrators of The Tulane Educational Fund Therapeutic decapeptides
EP0328090A2 (en) * 1988-02-10 1989-08-16 Abbott Laboratories LHRH analogs
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
EP0413209A1 (en) * 1989-08-07 1991-02-20 TAP Pharmaceuticals Inc. LHRH analogs
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530920A (en) * 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
DE3634435A1 (en) * 1986-10-09 1988-04-14 Hoechst Ag ANALOGA OF GONADOLIBERIN WITH IMPROVED SOLUBILITY, METHOD FOR THE PRODUCTION THEREOF, THE CONTAINERS THEREOF AND THEIR USE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928307A (en) * 1974-11-04 1975-12-23 American Home Prod P-Glu-D-Phe-Trp-Ser-Tyr-D-Phee-Leu-Arg-Pro-Gly-NH2 and intermediates
US3933782A (en) * 1974-11-14 1976-01-20 American Home Products Corporation (N-Acetyl)-Pro-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt and intermediates
US4089946A (en) * 1976-06-07 1978-05-16 American Home Products Corporation Claudogenic-interceptive nonapeptides

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038135A3 (en) * 1980-04-15 1982-01-06 The Salk Institute For Biological Studies Lrf antagonists
JPS5735550A (en) * 1980-04-15 1982-02-26 Salk Inst For Biological Studi Improved lrf antagonist
JPH0139440B2 (en) * 1980-04-15 1989-08-21 Saruku Inst Fuoo Baiorojikaru Sutadeiizu Za
EP0038135A2 (en) * 1980-04-15 1981-10-21 The Salk Institute For Biological Studies LRF antagonists
EP0041286A1 (en) * 1980-06-02 1981-12-09 Andrew Victor Schally LH-RH antagonists
EP0063423A1 (en) * 1981-04-21 1982-10-27 The Salk Institute For Biological Studies GnRH antagonists
EP0122712A2 (en) * 1983-03-10 1984-10-24 The Salk Institute For Biological Studies GnRH antagonists
EP0122712A3 (en) * 1983-03-10 1986-05-14 The Salk Institute For Biological Studies Gnrh antagonists
EP0162575A3 (en) * 1984-05-21 1987-10-07 The Salk Institute For Biological Studies Gnrh antagonists vii
EP0162575A2 (en) * 1984-05-21 1985-11-27 The Salk Institute For Biological Studies GnRH Antagonists VII
EP0171477A3 (en) * 1984-06-18 1987-10-14 The Administrators Of The Tulane University Educational Fund Amino acid-containing therapeutic compounds
EP0171477A2 (en) * 1984-06-18 1986-02-19 The Administrators Of The Tulane University Educational Fund Amino acid-containing therapeutic compounds
EP0197798A2 (en) * 1985-04-09 1986-10-15 The Administrators Of The Tulane University Educational Fund Peptides
EP0197798A3 (en) * 1985-04-09 1988-07-27 Administrators Of The Tulane Educational Fund Peptides
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
EP0225746A3 (en) * 1985-11-14 1989-12-20 The Administrators of The Tulane Educational Fund Therapeutic decapeptides
EP0225746A2 (en) * 1985-11-14 1987-06-16 The Administrators of The Tulane Educational Fund Therapeutic decapeptides
EP0328090A2 (en) * 1988-02-10 1989-08-16 Abbott Laboratories LHRH analogs
EP0328090A3 (en) * 1988-02-10 1990-08-16 Abbott Laboratories Lhrh analogs
EP0400065A1 (en) * 1988-02-10 1990-12-05 Abbott Lab Lhrh analogs.
EP0400065A4 (en) * 1988-02-10 1991-03-13 Abbott Laboratories Lhrh analogs
EP0413209A1 (en) * 1989-08-07 1991-02-20 TAP Pharmaceuticals Inc. LHRH analogs
AU672474B2 (en) * 1989-08-07 1996-10-03 Abbott Laboratories LHRH analogs
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist

Also Published As

Publication number Publication date
NL7811723A (en) 1979-06-01
DE2851630A1 (en) 1979-05-31
AU4194878A (en) 1979-06-07
GB2009182B (en) 1982-02-24
SE444946B (en) 1986-05-20
NZ188987A (en) 1982-02-23
FR2410642B1 (en) 1983-10-21
CH639942A5 (en) 1983-12-15
AU520419B2 (en) 1982-01-28
CA1116594A (en) 1982-01-19
FR2410642A1 (en) 1979-06-29
SE7812255L (en) 1979-05-31

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Publication Publication Date Title
GB2009182A (en) Peptides which inhibit gonadal function
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US4547370A (en) GnRH Antagonists
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CA1302650C (en) Gnrh antagonists viii
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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee