GB2042887B - Albumin microaggregates for radioactive scanning of reticuloendothelial systems - Google Patents
Albumin microaggregates for radioactive scanning of reticuloendothelial systemsInfo
- Publication number
- GB2042887B GB2042887B GB7906298A GB7906298A GB2042887B GB 2042887 B GB2042887 B GB 2042887B GB 7906298 A GB7906298 A GB 7906298A GB 7906298 A GB7906298 A GB 7906298A GB 2042887 B GB2042887 B GB 2042887B
- Authority
- GB
- United Kingdom
- Prior art keywords
- albumin
- microaggregates
- reticuloendothelial systems
- radioactive scanning
- reducing metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1255—Granulates, agglomerates, microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Abstract
Micro aggregates of albumin wherein the albumin particles comprise a reducing metal e.g. tin bound thereto and also Tc-99 m radioactively labeled such microaggregates are useful for imaging of reticuloendothelial systems (RES), especially the liver, spleen and bone marrow. Compositions may also contain a stabilizing ligand for the reducing metal e.g. a phosphonate, phosphate, aminocarboxylate, polyhydroxycarboxylate or polycarboxylates.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7906298A GB2042887B (en) | 1979-02-22 | 1979-02-22 | Albumin microaggregates for radioactive scanning of reticuloendothelial systems |
FR7905669A FR2450611A1 (en) | 1979-02-22 | 1979-03-05 | ALBUMIN MICRO-AGGREGATES FOR RADIOACTIVE EXPLORATION OF CROSS-ENDOTHELIAL SYSTEMS |
NL7901767A NL190050C (en) | 1979-02-22 | 1979-03-06 | PREPARATION SUITABLE FOR USE, AFTER MARKING WITH TC-99M, AS A RADIO-DIAGNOSTIC AGENT. |
SE7902009A SE431286B (en) | 1979-02-22 | 1979-03-06 | ALBUMIN MICROAGGER FOR RADIOACTIVE INVESTIGATION OF RETICULOENDOTELIAL SYSTEM AND SET FOR PRODUCING THEREOF |
DE19792909355 DE2909355C2 (en) | 1979-02-22 | 1979-03-09 | Composition for the radioactive display of the reticulo-endothelial system, method for the preparation of the composition and a radiodiagnostic containing the composition |
JP3540079A JPS55130921A (en) | 1979-02-22 | 1979-03-26 | Albumin microaggregate for radioactive scanning in reticuloendotissue system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7906298A GB2042887B (en) | 1979-02-22 | 1979-02-22 | Albumin microaggregates for radioactive scanning of reticuloendothelial systems |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2042887A GB2042887A (en) | 1980-10-01 |
GB2042887B true GB2042887B (en) | 1983-10-12 |
Family
ID=10503365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7906298A Expired GB2042887B (en) | 1979-02-22 | 1979-02-22 | Albumin microaggregates for radioactive scanning of reticuloendothelial systems |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS55130921A (en) |
DE (1) | DE2909355C2 (en) |
FR (1) | FR2450611A1 (en) |
GB (1) | GB2042887B (en) |
NL (1) | NL190050C (en) |
SE (1) | SE431286B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4410507A (en) | 1981-08-28 | 1983-10-18 | Solco Basel Ag | Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8310038D0 (en) * | 1983-04-13 | 1983-05-18 | Amersham Int Plc | Technetium-99 labelled tin colloid |
SE463651B (en) * | 1983-12-21 | 1991-01-07 | Nycomed As | DIAGNOSTIC AND CONTRACTOR |
SU1708350A1 (en) * | 1988-04-15 | 1992-01-30 | Оренбургский Государственный Медицинский Институт | Bacillus subtilis strain as radionuclide carrier |
ES2096521B1 (en) * | 1994-08-10 | 1997-11-16 | Univ La Laguna | BIODEGRADABLE SYNTHETIC POLYMER MICROSPHERES IN THE MANUFACTURE AND ELABORATION OF REACTIVE EQUIPMENT FOR THE PREPARATION OF RADIOPHARMACEUTICAL MEDICINES. |
EP1683517A1 (en) * | 1996-08-19 | 2006-07-26 | American Bioscience, Inc. | Methods for the production of protein particles useful for delivery of pharmacological agents |
EP2511707B1 (en) * | 2009-12-10 | 2017-02-01 | Sysmex Corporation | Method for detection of basic peptide and reagent for detection of basic peptide |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2281134A1 (en) * | 1974-08-06 | 1976-03-05 | Commissariat Energie Atomique | 99M TECHNETIUM MARKING PROCESS |
US3987157A (en) * | 1974-08-29 | 1976-10-19 | Union Carbide Corporation | Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation |
US4094965A (en) * | 1977-04-01 | 1978-06-13 | New England Nuclear Corporation | Diagnostic agents containing albumin and method for making same |
-
1979
- 1979-02-22 GB GB7906298A patent/GB2042887B/en not_active Expired
- 1979-03-05 FR FR7905669A patent/FR2450611A1/en active Granted
- 1979-03-06 NL NL7901767A patent/NL190050C/en not_active IP Right Cessation
- 1979-03-06 SE SE7902009A patent/SE431286B/en not_active IP Right Cessation
- 1979-03-09 DE DE19792909355 patent/DE2909355C2/en not_active Expired
- 1979-03-26 JP JP3540079A patent/JPS55130921A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4410507A (en) | 1981-08-28 | 1983-10-18 | Solco Basel Ag | Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use |
Also Published As
Publication number | Publication date |
---|---|
NL190050C (en) | 1993-10-18 |
GB2042887A (en) | 1980-10-01 |
JPS55130921A (en) | 1980-10-11 |
SE431286B (en) | 1984-01-30 |
FR2450611A1 (en) | 1980-10-03 |
DE2909355A1 (en) | 1980-09-11 |
NL7901767A (en) | 1980-09-09 |
NL190050B (en) | 1993-05-17 |
JPH0343254B2 (en) | 1991-07-01 |
FR2450611B1 (en) | 1983-02-25 |
SE7902009L (en) | 1980-09-07 |
DE2909355C2 (en) | 1985-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19950222 |